Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Singh, Anurag; Laux, Peter; Luch, Andreas; Sudrik, Chaitanya; Wiehr, Stefan; Wild, Anna‐Maria; Santomauro, Giulia; Bill, Joachim; Sitti, Metin

doi:10.1080/15376516.2019.1566425

Cited by 170 publications

(101 citation statements)

References 71 publications

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Section: Knowledge Gaps In Human and Environmental Risk Assessmentmentioning

confidence: 99%

“…For all NPs studies, a crucial issue remains the composition, particle surface area, surface chemistry, and the careful, accurate characterization of particle size and morphologic features, especially in the physiological environment [202]. Moreover, equally important to the latter is the control of assays and assay conditions [202]. It is only with the complete characterization of NPs and the appropriate control of assays that the results of reported studies can be comparable with those of other studies conducted with similar NMs [68,203].…”

Section: Knowledge Gaps In Human and Environmental Risk Assessmentmentioning

confidence: 99%

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Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Ferdous

Nemmar

2020

IJMS

690

354

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Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructures and have been intensively investigated for their unique physicochemical properties. The widespread commercial and biomedical application of nanosilver include its use as a catalyst and an optical receptor in cosmetics, electronics and textile engineering, as a bactericidal agent, and in wound dressings, surgical instruments, and disinfectants. This, in turn, has increased the potential for interactions of AgNPs with terrestrial and aquatic environments, as well as potential exposure and toxicity to human health. In the present review, after giving an overview of ENMs, we discuss the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure. Most in vitro studies have demonstrated the size-, dose- and coating-dependent cellular uptake of AgNPs. Following NPs exposure, in vivo biodistribution studies have reported Ag accumulation and toxicity to local as well as distant organs. Though there has been an increase in the number of studies in this area, more investigations are required to understand the mechanisms of toxicity following various modes of exposure to AgNPs.

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Section: Knowledge Gaps In Human and Environmental Risk Assessmentmentioning

confidence: 99%

Section: Knowledge Gaps In Human and Environmental Risk Assessmentmentioning

confidence: 99%

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Ferdous

Nemmar

2020

IJMS

690

354

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“…The findings of this research provide insights for the formation of the principles of safe design, production, and utilization of NPs [51]. We believe that safety ensuring in nanotechnology would be provided only by international cooperation and large-scale nanotoxicology research, including the approaches of bioinformatics, system biology and other methods of modeling, prediction, and maintaining the handling and interpretation the growing body of research data.…”

Section: Discussionmentioning

confidence: 88%

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

Pikula¹,

Чайка²,

Zakharenko³

et al. 2020

Preprint

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Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Additionally, poor understanding of how physical and chemical characteristic and different conditions influence the toxicity of NPs restrict our attempts to develop the standards and regulations which might allow us to maintain the safe living conditions. The marine species and their habitat environment are under continuous stress due to anthropogenic activities which result in the appearance of NPs in the aquatic environment. Our study aimed to evaluate and compare biochemical effects caused by the influence of different types of carbon nanotubes, carbon nanofibers, and silica nanotubes on four marine microalgae species. We have evaluated the changes in growth-rate, esterase activity, membrane polarization, and size changes of microalgae cells using flow cytometry method. Our results demonstrated that toxic effects caused by the carbon nanotubes strongly correlated with the content of heavy metal impurities in the NPs. More hydrophobic carbon NPs with less ordered structure had a higher impact on the red microalgae P. purpureum because of higher adherence between the particles and mucous covering of the algae; silica NPs caused significant inhibition of microalgae growth-rate predominantly produced by mechanical influence.

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“…− ions), the A549 cells were gently washed with PBS (pH 7.2) to avoid disturbing the intracellular and extracellularly synthesized micro/nanostructures on cell membranes [15][16][17][18] . Subsequently cells were fixed in 4% paraformaldehyde (PFA in PBS, Sigma Aldrich, Germany) for 30 min at room temperature.…”

Section: Sample Preparation and Tof-sims Analysis After Incubating Amentioning

confidence: 99%

ToF-SIMS 3D imaging unveils important insights on the cellular microenvironment during biomineralization of gold nanostructures

Singh

Jungnickel

Leibrock

et al. 2020

Sci Rep

Self Cite

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The biomolecular imaging of cell-nanoparticle (NP) interactions using time-of-flight secondary ion mass spectrometry (ToF-SIMS) represents an evolving tool in nanotoxicology. In this study we present the three dimensional (3D) distribution of nanomaterials within biomolecular agglomerates using ToF-SIMS imaging. This novel approach was used to model the resistance of human alveolar A549 cells against gold (Au) ion toxicity through intra-and extracellular biomineralization. At low Au concentrations (≤1 mM HAuCl 4) 3D-ToF-SIMS imaging reveals a homogenous intracellular distribution of Au-NPs in combination with polydisperse spherical NPs biomineralized in different layers on the cell surface. However, at higher precursor concentrations (≥2 mM) supplemented with biogenic spherical NPs as seeds, cells start to biosynthesize partially embedded long aspect ratio fiber-like Au nanostructures. Most interestingly, A549 cells seem to be able to sense the enhanced Au concentration. They change the chemical composition of the extracellular NP agglomerates from threonine-O-3-phosphate aureate to an arginine-Au(I)-imine. Furthermore they adopt the extracellular mineralization process from spheres to irregular structures to nanoribbons in a dose-dependent manner with increasing Au concentrations. The results achieved regarding size, shape and chemical specificity were cross checked by SEM-EDX and single particle (sp-)ICP-MS. Our findings demonstrate the potential of ToF-SIMS 3D imaging to better understand cell-NP interactions and their impact in nanotoxicology. Au nano-or microparticles are promising candidates for both bioimaging and therapeutic applications 1. Recently, cell based biomineralization has been explored as a novel technique to synthesize versatile 0, 1, and 2 dimensional gold nanostructures under ambient synthesis conditions. For example, cancer cells are known to synthesize NPs de novo 2 from Au ions. However, little is known about how the surrounding chemical environment influences the extracellular biomineralization at the cell membrane interface and what effect this then has on uptake and biocompatibility. Time of Flight-Secondary Ion Mass Spectrometry (ToF-SIMS) is a versatile and noninvasive technique that allows for both label free imaging and analysis of the surface composition. Conventional scanning electron microscope-energy dispersive X-ray (SEM-EDX) imaging or fluorescence labelling of biological cells not only perturbs the cellular state but also limits the analysis to a specific number of fluorescence labeled targets. On the contrary, ToF-SIMS provides a more versatile method for the visualization of multiple chemicals or intracellular metabolites within individual cells 3. The submicron lateral resolution in combination with a high depth resolution for organic samples (down to 10 nm 3) enables the three dimensional (3D) label-free reconstruction of single cells. This makes ToF-SIMS a top emerging and evolving tool for studies relating to the chemical distribution within single cells 4. Here we app...

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Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Cited by 170 publications

References 71 publications

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae

ToF-SIMS 3D imaging unveils important insights on the cellular microenvironment during biomineralization of gold nanostructures

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