Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives

Hajiali, Hadi; Ouyang, Liliang; Llopis-Hernández, Virginia; Dobre, Oana; Rose, Felicity R. A. J.

doi:10.1039/d1nr01371h

Cited by 40 publications

(20 citation statements)

References 112 publications

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“…The success of tissue engineering heavily depends on the performance of the materials. For the desired bone regeneration materials, excellent biocompatibility, controlled biodegradability, appropriate mechanical strength, and suitable porosity to support cell differentiation, growth, and proliferation all should be emphasized (Kim et al, 2013;Freeman et al, 2021;Hajiali et al, 2021). Research on graphene-based nanomaterials has boomed in biomaterial applications over the past few years.…”

Section: Introductionmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Bone regeneration or replacement has been proved to be one of the most effective methods available for the treatment of bone defects caused by different musculoskeletal disorders. However, the great contradiction between the large demand for clinical therapies and the insufficiency and deficiency of natural bone grafts has led to an urgent need for the development of synthetic bone graft substitutes. Bone tissue engineering has shown great potential in the construction of desired bone grafts, despite the many challenges that remain to be faced before safe and reliable clinical applications can be achieved. Graphene, with outstanding physical, chemical and biological properties, is considered a highly promising material for ideal bone regeneration and has attracted broad attention. In this review, we provide an introduction to the properties of graphene and its derivatives. In addition, based on the analysis of bone regeneration processes, interesting findings of graphene-based materials in bone regenerative medicine are analyzed, with special emphasis on their applications as scaffolds, membranes, and coatings in bone tissue engineering. Finally, the advantages, challenges, and future prospects of their application in bone regenerative medicine are discussed.

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Section: Introductionmentioning

confidence: 99%

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Jin

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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“…Fracture healing is a complex regeneration process. In the past, a large number of studies applied MSCs to treat fracture healing, and nanomaterials have been widely used in the field of tissue regeneration (including bone regeneration) (30,31). In this study, we applied ADMSCs combined with PtNPs in a rat tibial fracture model.…”

Section: Discussionmentioning

confidence: 99%

Adipose-derived mesenchymal stem cells combined with platinum nanoparticles accelerate fracture healing in a rat tibial fracture model

Chen¹,

Yuan²,

Jin³

et al. 2022

Ann Transl Med

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Background: At present, bone union delay or failure remains challenging for clinicians. It has been reported that adipose-derived mesenchymal stem cells (ADMSCs) offer a promising way to promote bone fracture healing. In recent years, nanomaterials have been applied in regenerative medicine. This study aimed to investigate whether ADMSCs combined with platinum nanoparticles (PtNPs) could further improve fracture healing on the basis of ADMSCs.Methods: ADMSCs were co-cultured with PtNPs in vitro to investigate the effect of PtNPs on the differentiation of ADMSCs. Twenty Sprague-Dawley (SD) rats were randomly divided into four groups (with five rats in each group). The left tibias of all rats were fractured. Phosphate-buffered saline (PBS), PtNPs, ADMSC, and ADMSC mixed with PtNPs were then injected into the fracture sites based on the group classifications. The fracture was monitored by X-ray immediately after the fracture and on days 14 and 28 post-fracture. The tibias of the rats were subsequently harvested after the last X-ray and evaluated by micro computed tomography (micro-CT), histological analysis, and immunohistochemical detection.Results: PtNPs significantly enhanced the osteogenic differentiation of ADMSCs in vitro. On days 14 and 28 post-fracture, the radiographic score of the ADMSC + PtNPs group was higher than that of the ADMSC group, the score of the ADMSC group was higher than that of the PtNPs and control groups, and there was no significant difference between the PtNPs and control groups. Micro-CT confirmed that combined ADMSCs with PtNPs were more effective than using ADMSCs alone in promoting fracture healing. The histological and immunohistochemical results further supported this conclusion.Conclusions: Our findings demonstrated that PtNPs could promote osteogenic differentiation of ADMSC in vitro. ADMSCs combined with PtNPs could accelerate fracture healing further in vivo and are a promising a potential method for the treatment of fracture healing.

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“…Xing and others have also found that the (3-hydroxybutyrate-3-hydroxyvalerate) nanofibers containing metallic silver particles can promote the differentiation of osteoblasts, at the same time, it has good antibacterial effect and good cell compatibility, can play a certain auxiliary role in the regeneration of osteoblasts [80]. The latest study shows the application of glass-based nanocomposites can used for drug delivery to stimulate bone repair [81]. There are also studies have found that silica nanoparticles inhibit osteoclasts and promote osteoblasts by antagonizing NF-kB, can promote the increasing of bone minerals, as a result, in the prevention of diabetes osteoporosis and bone tissue regeneration can play a positive role , the toxicity of these nanoparticles to the retina at different diameters is under further investigation [82].…”

Section: Othersmentioning

confidence: 97%

Application progress of nanotechnology in regenerative medicine of diabetes mellitus

Liu

2022

Diabetes Research and Clinical Practice

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Review of emerging nanotechnology in bone regeneration: progress, challenges, and perspectives

Abstract: The application of nanotechnology to regenerative medicine has increased over recent decades. The development of materials that can influence biology at the nanoscale has gained interest as our understanding of...

Cited by 40 publications

References 112 publications

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Graphene and its Derivatives for Bone Tissue Engineering: In Vitro and In Vivo Evaluation of Graphene-Based Scaffolds, Membranes and Coatings

Adipose-derived mesenchymal stem cells combined with platinum nanoparticles accelerate fracture healing in a rat tibial fracture model

Application progress of nanotechnology in regenerative medicine of diabetes mellitus

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