Review of Endometriosis Diagnosis through Advances in Biomedical Engineering

Shah, Ruchi; Jagani, Ravi Pankajbhai

doi:10.1615/critrevbiomedeng.2018027414

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endometriosis is characterized by the presence of uterine stroma and glands outside the uterine cavity, predominantly on the pelvic peritoneum and ovaries. It affects approximately 5–10% of women of reproductive age and represent a significant disease burden ( Shah and Jagani, 2018 ; Simitsidellis et al, 2018 ; Zondervan et al, 2018 ). While pelvic and abdominal pain symptoms (e.g., chronic pelvic pain, dysmenorrhea, dyspareunia) and subfertility are the most common clinical signs of endometriosis ( Mechsner, 2016 ), many relevant co-morbidities with affective disorders like depression or anxiety are described and have severe impact on quality of life of patients ( Brandes, 2007 ; Facchin et al, 2015 , 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosis

Nunez-Badinez

Laux-Biehlmann²,

Hayward³

et al. 2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the presence and growth of endometrial tissue outside the uterine cavity. It is associated with moderate to severe pelvic and abdominal pain symptoms, subfertility and a marked reduction in health-related quality of life. Furthermore, relevant co-morbidities with affective disorders like depression or anxiety have been described. These conditions have a worsening effect on pain perception in patients and might explain the negative impact on quality of life observed in those suffering from endometriosis-associated pain. Whereas several studies using rodent models of endometriosis focused on biological and histopathological similarities with the human situation, the behavioral characterization of these models was never performed. This study investigated the anxiety-related behaviors in a syngeneic model of endometriosis. Using elevated plus maze and the novel environment induced feeding suppression assays we observed the presence of anxiety-related behaviors in endometriosis-induced mice. In contrast, locomotion or generalized pain did not differ between groups. These results indicate that the presence of endometriosis lesions in the abdominal cavity could, similarly to patients, induce profound psychopathological changes/impairments in mice. These readouts might provide additional tools for preclinical identification of mechanisms relevant for development of endometriosis-related symptoms.

show abstract

Section: Introductionmentioning

confidence: 99%

Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosis

Nunez-Badinez

Laux-Biehlmann²,

Hayward³

et al. 2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The uterus, a structure of mesodermal origin, is a hollow muscular organ with thick walls and unique anatomical and histological characteristics. It has two uterine tubes that attach to the uterus, creating a path for the passage of ovum from the ovaries to the uterus, for later fertilization and implantation in the endometrium [1]. The uterine wall consists of several layers: the perimetrium, a serous lining; an outermost layer that comprises the peritoneum and is supported by surrounding layers of connective tissue; the middle layer of the uterus known as the myometrium, one of the most dynamic layers of the uterus, suffering great distensions to allow the accommodation of various arteries and nerves, especially during pregnancy; and the endometrium, the innermost lining of the myometrium and the most active layer, as it undergoes different changes during the menstrual cycle [2].…”

Section: Introduction 1endometrial Physiology and Menstrual Cyclementioning

confidence: 99%

Endometriosis: A Disease with Few Direct Treatment Options

2022

View full text Add to dashboard Cite

Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.

show abstract

Photoacoustic Imaging Endometriosis Lesions with Nanoparticulate Polydopamine as a Contrast Agent

Lv,

Zhang,

Yang

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Abstract. Endometriosis (EM) is a prevalent and debilitating gynecological disorder primarily affecting women of reproductive age. The diagnosis of EM has historically been hampered by delays, owing to the absence of reliable diagnostic and monitoring techniques. We herein reported that photoacoustic imaging could be a non‐invasive modality for deep‐seated EM by employing a hyaluronic acid‐modified polydopamine (PDA@HA) nanoparticle as the contrast agent. The PDA@HA nanoparticles exhibited inherent absorption and photothermal effects when exposed to near‐infrared light, proficiently converting thermal energy into sound waves. Leveraging the targeting properties of HA, we observed distinct photoacoustic signals emanating from the periphery of orthotopic EM lesions. These findings were corroborated through anatomical observations and in vivo experiments involving mice with green fluorescent protein‐labeled EM lesions. Moreover, the changes in photoacoustic intensity over a 24‐hour period reflected the dynamic evolution of PDA@HA nanoparticle biodistribution. Through the utilization of a photoacoustic‐ultrasound modality, we conducted in vivo assessments of endometriosis (EM) lesion volumes. This innovative approach not only facilitates real‐time monitoring of the therapeutic kinetics of candidate drugs but also obviates the need for the sacrifice of experimental mice. As such, our study presents a promising avenue for enhancing the diagnosis and drug screening processes of EM.This article is protected by copyright. All rights reserved

show abstract

Review of Endometriosis Diagnosis through Advances in Biomedical Engineering

Cited by 3 publications

References 0 publications

Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosis

Anxiety-related behaviors without observation of generalized pain in a mouse model of endometriosis

Endometriosis: A Disease with Few Direct Treatment Options

Photoacoustic Imaging Endometriosis Lesions with Nanoparticulate Polydopamine as a Contrast Agent

Contact Info

Product

Resources

About