Review of Exercise Interventions to Improve Clinical Outcomes in Nondialysis CKD

Hayden, Christopher M.T.; Begue, Gwénaëlle; Gamboa, Jorge L.; Baar, Keith; Roshanravan, Baback

doi:10.1016/j.ekir.2024.07.032

Kidney International Reports

2024

DOI: 10.1016/j.ekir.2024.07.032

|View full text |Cite

Review of Exercise Interventions to Improve Clinical Outcomes in Nondialysis CKD

Christopher M.T. Hayden,

Gwénaëlle Begue,

Jorge L. Gamboa

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 210 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease

Chang

2024

Exerc Sci

View full text Add to dashboard Cite

PURPOSE: Chronic kidney disease (CKD) is a major global health issue characterized by a gradual and irreversible decline in renal function. Despite its increasing prevalence, effective therapeutic options remain limited, highlighting the need for novel treatment approaches. This review highlights the importance of exercise as a nonpharmacological intervention by exploring the role of exerciseinduced bioactive molecules in CKD management.METHODS: An extensive literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar. The search terms included “myokine,” “exerkine,” “chronic kidney disease,” “nephropathy,” “renal function,” “podocyte,” “mesangial cell,” “exercise,” “physical activity,” and other related terms.RESULTS: Exercise-induced molecules, particularly myokines and exerkines, can slow the progression of CKD through protective mechanisms. These molecules reduce oxidative stress via antioxidant defense pathways, regulate immune responses to limit inflammation, and inhibit fibrotic signaling by interacting with TGF-β and other pro-fibrotic factors. Furthermore, they preserve renal function by maintaining podocyte and mesangial cell integrity and modulating autophagy, thereby preventing kidney damage.CONCLUSIONS: This review consolidates the current knowledge on the therapeutic potential and diverse functions of exercise-induced molecules in CKD, offering insights into their ability to slow disease progression and improve patient outcomes through nonpharmacological strategies.

show abstract

The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease

Chang

2024

Exerc Sci

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Review of Exercise Interventions to Improve Clinical Outcomes in Nondialysis CKD

Cited by 1 publication

References 210 publications

The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease

The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease

Contact Info

Product

Resources

About