“…To overcome these obstacles, various formulations have been proposed, including complexation with cyclodextrins (Fir, Smidovnik, Milivojevic, Zmitek, & Prosek, ), complexation with albumin hydrolysate (Matsushita, Oshima, Takahashi, & Baba, ), solid dispersions (Bhandari et al., ), and nanoformulations (Cheuk et al., ; Kaci et al., ; Lee, Suh, Kim, & Lee, ; Qin et al., ). As most of these approaches led to low‐to‐moderate success (Hatanaka, Kimura, Lai‐Fu, Onoue, & Yamada, ; Piao et al., ; Zhou et al., ), new strategies, especially green ones (Chemat et al., ), are in great demand, aiming not only to increase the solubility of CoQ10, but also to eliminate the use of any surfactant or organic solvent. These chemical additives are frequently employed to deal with hydrophobic compounds; however, most of which are not inert from the perspective of pharmaceutical product quality and lead to a variety of vehicle‐related side effects (Abrantes, Duarte, & Reis, ).…”