Hemodialysis is the most preferred renal replacement therapy for patients with chronic kidney failure worldwide. The indicator of the success of hemodialysis therapy is the fulfillment of the adequacy of the hemodialysis dose as measured by Kt/V. Many factors affect the adequacy of hemodialysis, including internal factors and external factors of the patient. This study aimed to analyze the factors that affect the adequacy of hemodialysis in patients undergoing hemodialysis at Indramayu Hospital. Research design using a cross-sectional approach. The sample in this study was 44 respondents who were taken based on purposive sampling. The result showed that the average Kt/V was 1.71 with the lowest Kt/V value being 0.76 and the highest Kt/V being 2.33. Of 44 respondents, 24 (54.5 %) found adequacy achieved, and 20 (45.5 %) respondents did not achieve adequacy. Factors related to hemodialysis adequacy are gender (p=0.000; OR=4.0), dry weight (p=0.006; OR=7.286), dialyzer reuse (p=0.005; OR=8.000), and quick of blood (p=0.38; OR=4.5). Suggestions for hemodialysis nurses to be able to evaluate, especially the use of dialyzer reuse no more than 4 times, and maintain a quick blood speed of at least 250 ml/minute to achieve adequacy.