Review of image defined risk factors in localized neuroblastoma patients: Results of the GPOH NB97 trial

Simon, Thorsten; Hero, Barbara; Benz-Bohm, G.; Schweinitz, Dietrich von; Berthold, Frank

doi:10.1002/pbc.21343

Cited by 82 publications

(78 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The outcome for patients with localised neuroblastoma is favourable with reported OS rates for INSS stage 1 at 98-99% [11], stage 2: 95-99% [7,11] and stage 3: 84% [7]. Similar results were obtained in the present study, with OS in stages 1-3 respectively 99%, 93% and 83%.…”

Section: Discussionsupporting

confidence: 81%

“…We, as others, have confirmed that absence or presence of IDRF is helpful in selecting neuroblastoma patients that may benefit from primary surgery [11,16,17]. The IDRF status of the primary tumour may also be used to assess the risk of surgery in metastatic neuroblastoma [8,18].…”

Section: Discussionmentioning

confidence: 82%

“…Today survival in localised neuroblastoma is more than 90% [7,11]. In light of the excellent prognosis combined with current knowledge it can be inferred that a number of survivors received more treatment than necessary.…”

Section: Discussionmentioning

confidence: 99%

“…A sample size of around 1,500 patients would be required to demonstrate significance at a 5% level between 98% and 95%. Under-powering was probably the reason why an OS of 98% in patients without IDRF was not significantly better than 96% in patients with IDRF in a German study [11].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundThe European multicenter study LNESG1 was designed to evaluate the safety and efficacy of surgical treatment alone in patients with localised neuroblastoma. In a retrospective, observational study we examined the impact of image‐defined risk factors (IDRF) on operative complications and survival (EFS and OS).Procedure534 patients with localised, non‐MYCN amplified neuroblastoma were recruited between 1995 and 1999. Group 1 consisted of 291 patients without IDRF (Stage L1 in the International Neuroblastoma Risk Group (INRG) staging system), all treated with primary surgery. Group 2: 118 patients with IDRF (INRG Stage L2), also treated with primary surgery. Group 3: 125 patients in whom primary surgery was not attempted, 106 receiving neo‐adjuvant chemotherapy.ResultsIn L1 patients (Group 1) 5‐year EFS was 92% and OS 98%. In L2 patients (Group 2 and 3) EFS was 79% and OS 89%. The differences in both EFS and OS were significant. EFS and OS in Group 2 (86% and 95%) were significantly better than 73% and 83% in Group 3. In INSS stage 1, 2 and 3, EFS were respectively 94%, 81% and 76%. Except between stage 2 and 3 the differences were significant. OS were respectively 99%, 93% and 83%, all significantly different. The 17% operative complication rate in L2 patients was significantly higher than 5% in L1 patients.ConclusionsIn localised neuroblastoma, IDRF at diagnosis are associated with worse survival rates and higher rates of operative complications. The impact of IDRF should become an integrated part of therapy planning. Pediatr Blood Cancer 2015;62:1536–1542. © 2015 Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Neuroblastoma, the most common extra cranial malignance in children, has established image-defined risk factors during its primary evaluation [46][47][48] and studies showed similar findings of sensibility and specificity on both CT and MR [49]. Early therapy response can be very well evaluated by WB-MRI, possibly even better than I-MIBG [18], but, unfortunately, late therapy evaluation has the same limitation as lymphomas in dealing with scar and residual disease [38 5 Localized STIR images of a lymphoma treatment follow up, there is a good therapy response, different to other total body scan follow up images that can be evaluated by a localized series generated before reconstruction DWI also found significant difference of the ADC map of neuroblastoma compared to ganglioneuroma and ganglioneuroblastoma, adding probably a new utility for this sequence on WB-MRI following further studies [50].…”

Section: Neuroblastoma and Other Small Cell Neoplasmmentioning

confidence: 99%

Whole Body MRI and Diffusion Weighed Images in Pediatric Oncology: Lymphomas and Several Others Tumors

Schiavon

Lederman

2014

Curr Radiol Rep

View full text Add to dashboard Cite

Cancer in a pediatric population represents the majority of non-related to trauma deaths. In most developed and emerging countries there is a need for early and accurate imaging detection, usually with fast examinations protocols, and no or low radiation exposure to avoid a secondary radiation induced neoplasia. The advance of magnetic resonance imaging techniques permitting the use of whole body images on oncology patients and multifocal diseases and the use of diffusion weight images DWI techniques allow additional metabolic information for WB-MRI with growing evidence that the disease metabolic activity is correlated with cellularity in some tumors. This permits DWI sequences and suggests tumor activity with the therapy response as an alternative to PET-CT. WB-MRI has proved to be more sensitive than scintigraphy in detecting both marrow and non-marrow involvement on lymphoma patients and can be a very good alternative to those who cannot undergo a PET-CT. Other small cell neoplasms such as Ewing family, neuroblastoma and some sarcomas also have been effective evaluated by WB-MRI. On palliative care patients, WB-MRI plays a rule on detecting lesions that can cause pain or pressure over vital structures. In conclusion, WB-MRI has been proved an extremely useful method on multifocal diseases and oncology with the same routine MR contraindications and should be, respecting the limitations inherent to any radiology method, accepted as another powerful tool especially in pediatric oncology. It can be used to avoid radiation exposure related disease and could be more available to these patients.

show abstract

Neuroblastoma

Vaidya¹,

Pearson²

2010

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

Review of image defined risk factors in localized neuroblastoma patients: Results of the GPOH NB97 trial

Abstract: IDRF were useful in predicting risk and completeness of operation. IDRF failed as independent risk predictors in localized neuroblastoma. INSS more precisely identified patients with poor prognosis.

Cited by 82 publications

References 6 publications

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Whole Body MRI and Diffusion Weighed Images in Pediatric Oncology: Lymphomas and Several Others Tumors

Neuroblastoma

Contact Info

Product

Resources

About