Review of Innovative Physical Therapy Methods: Introduction to the Principles of Cold Physical Plasma

Kletschkus, Karsten; Haralambiev, Lyubomir; Mustea, Alexander; Bekeschus, Sander; Stope, Matthias B.

doi:10.21873/invivo.12143

Cited by 17 publications

(9 citation statements)

References 18 publications

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“…The technical specifications of so-called 'cold plasma' devices make it feasible to generate nonthermal physical plasmas with temperatures little above the body temperature of mammals. These NIPPs do not cause nonspecific thermal effects, but mainly induce ROS-mediated cellular responses, 12 which are primarily responsible for the protherapeutic efficacy. [15][16][17][18]24 The NIPP device used in this case report generates nonthermal physical plasma.…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, however, this therapeutic approach is still far from being established. NIPP represents an approach that is based on highly energised gas transferring energy to molecules of the surrounding atmosphere 11 , 12 . As a consequence, reactive oxygen species (ROS) are being formed, which are causative for the protherapeutic biomedical effects of NIPP in medical applications 13 , 14 .…”

Section: Introductionmentioning

confidence: 99%

“…NIPP represents an approach that is based on highly energised gas transferring energy to molecules of the surrounding atmosphere. 11,12 As a consequence, reactive oxygen species (ROS) are being formed, which are causative for the protherapeutic biomedical effects of NIPP in medical applications. 13,14 ROS have numerous functions in controlling specific cell responses in healthy as well as in pathologically transformed tissues.…”

mentioning

confidence: 99%

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Non‐invasive physical plasma (NIPP) treatment of a hedgehog with head injury: A novel therapy in veterinary medicine

Nitsch

Napiletzki²,

Stope

2022

Vet Record Case Reports

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Non‐invasive physical plasma, known to have antimicrobial, immunostimulatory and epithelialising effects, has been successfully applied in this case to improve wound healing of an injured hedgehog. A European hedgehog (Erinaceus europaeus) with a head wound of approximately 1 cm2 was treated with non‐invasive physical plasma in addition to standard wound therapy. Non‐invasive physical plasma treatment of the wound in addition to the usual wound care resulted in wound closure after 11 days. Compared to previously treated hedgehogs with similar injury patterns but without non‐invasive physical plasma application, the application of non‐invasive physical plasma appears to accelerate wound healing. The application of non‐invasive physical plasma to treat wounds of hedgehogs offers accelerated wound healing compared to conventional wound care. This novel therapeutic option may be transferable to wound care in veterinary medicine in general.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Non‐invasive physical plasma (NIPP) treatment of a hedgehog with head injury: A novel therapy in veterinary medicine

Nitsch

Napiletzki²,

Stope

2022

Vet Record Case Reports

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“…Non-invasive physical plasma (NIPP) is emerging as a promising novel treatment modality for various skin conditions, such as psoriasis, eczema, diabetic ulcers, and different types of dermatitis [8,9]. Physical plasma is referred to as the fourth state of matter and is characterised by free electrons [10]. Contrary to thermal plasma, NIPP is generated using a high-frequency alternating field under atmospheric pressure, and therefore, only reaches room temperatures, rendering it safe for clinical application.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Physical Plasma for Preventing Radiation Dermatitis in Breast Cancer: A First-In-Human Feasibility Study

et al. 2022

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Radiation dermatitis (RD) is the most common acute side effect of breast irradiation. More than a century following the therapeutic utilisation of X-rays, potent preventative and therapeutic options are still lacking. Non-invasive physical plasma (NIPP) is an emerging approach towards treatment of various dermatological disorders. In this study, we sought to determine the safety and feasibility of a NIPP device on RD. Thirty patients undergoing hypofractionated whole-breast irradiation were included. Parallel to radiation treatment, the irradiated breast was treated with NIPP with different application regimens. RD was assessed during and after NIPP/radiation, using clinician- and patient-reported outcomes. Additionally, safety and feasibility features were recorded. None of the patients was prescribed topical corticosteroids and none considered the treatment to be unpleasant. RD was less frequent and milder in comparison with standard skin care. Neither NIPP-related adverse events nor side effects were reported. This proven safety and feasibility profile of a topical NIPP device in the prevention and treatment of RD will be used as the framework for a larger intrapatient-randomised double-blind placebo-controlled trial, using objective and patient-reported outcome measures as an endpoint.

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“…The synergistic effect of these components lead to a wide variety of plasma applications. [1][2][3] Plasma has been used in medicine for many years; it is used in the sterilization of surfaces of implanted materials, sterilization of medical instruments, and in wound treatment. 4,5 Cold plasma's sterilization applications include: i) rapid killing of bacteria, including multidrug-resistant bacteria; ii) killing of fungi; and iii) inhibiting the growth of viruses.…”

Section: Introductionmentioning

confidence: 99%

Cold Plasmamed Beam as a Supporting Treatment of Soft Tissue Injuries in Severe Covid-19 Patients: A Preliminary Report

Nguyen¹,

Nguyên²,

Ho-Man³

et al. 2022

MDER

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Background Cold plasma has many characteristics that allow for effective wound healing. Due to its efficacy, we have applied it in treating patients with severe Covid-19 who have soft tissue skin lesions and diseases including burns, pressure ulcers, shingles, and contact or atopic dermatitis. This study aims to assess the general characteristics of Covid-19 patients with soft tissue lesions and to conduct a fundamental evaluation of the efficacy of cold plasmamed beams in treating soft tissue wounds in patients with severe Covid-19. Methods This prospective study was conducted on 20 severe Covid-19 patients with soft tissue lesions at the Intensive Care Center for Covid-19 of Hue Central Hospital in Ho Chi Minh City from September 25 to November 11, 2021. These patients was performed cold plasma irradiation at any stage of wound progression, including new injuries and chronic wounds. Results Among 915 severe Covid-19 patients treated at our center, 20 patients had soft tissue lesions. Grade I, II, and III pressure ulcers accounted for 70% of the 20 cases of soft tissue lesions and 1.53% of the total patients at the time of the survey. Pressure ulcers were present in only 0.55% of patients (5/915 patients). Eleven out of 20 patients (55.0%) had lesions before admission, and 9 (45.0%) had lesions that appeared after admission. After 14 days of treatment, 14/20 patients had complete epithelialization (70%), and in 18/20 patients, wound exudation had ceased. The wounds became painless; after 3 weeks, the rashes had completely disappeared. Conclusion The study emphasizes that irradiation with cold plasma contributes to the wound healing process.

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Review of Innovative Physical Therapy Methods: Introduction to the Principles of Cold Physical Plasma

Cited by 17 publications

References 18 publications

Non‐invasive physical plasma (NIPP) treatment of a hedgehog with head injury: A novel therapy in veterinary medicine

Non‐invasive physical plasma (NIPP) treatment of a hedgehog with head injury: A novel therapy in veterinary medicine

Non-Invasive Physical Plasma for Preventing Radiation Dermatitis in Breast Cancer: A First-In-Human Feasibility Study

Cold Plasmamed Beam as a Supporting Treatment of Soft Tissue Injuries in Severe Covid-19 Patients: A Preliminary Report

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