Review of invasive meningococcal disease during the last 40 years in Turkey

Bakır, Mustafa; Altınel, Serdar

doi:10.1586/14760584.2015.1060859

Cited by 3 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28 A review of studies in Turkey shows that they are usually performed in a single region and include a limited number of participants, finding a carriage rate ranging from 1.2% to 28%. 12 Bakir et al 29 isolated N. meningitidis in 17 out of 1382 asymptomatic children aged 0-10 y and found a carriage rate of 1.23%; the most prevalent serogroup was Y, and there was no presence of serogroup C, similar to our study. The present study included adolescents and young adults from 12 provinces of Turkey and found a carriage rate of 6.3%, which is the most representative of the country so far.…”

Section: Discussionsupporting

confidence: 90%

“…10 It can be explained by the Hajj pilgrimage, which is among the effective risk factors associated with carriage in Turkey. In a study of specimens collected before and after the Hajj, Ceyhan et al 37 showed that the prevalence of carriage was 13% before and reached 27% after pilgrimage; 91% of the specimens were positive for serogroup W. In a review of 27 reports on invasive meningococcal infections over the past 40 y in Turkey, Bakir et al 12 found that the serogroup W was not common during the 1970s but became the most common invasive pathogen over time. Although serogroup W does not seem to be the most common cause in Turkish studies on carriage, we found that it was the most frequent cause, with a rate of 66.6%.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11] No carriage data are available for Turkey because all of these studies were conducted either in a single center or in wide range of age groups; further, the meningococcal carriage rate varied from 1.23% to 28%. 12 Characterizing N. meningitidis carriage in adolescents and young adults and serogroups in Turkey will improve our understanding of the epidemiology of invasive meningococcal infections and vaccination schedules. The objective of the present study was to characterize the nasopharyngeal carriage of N. meningitidis, determine the serogroups among the N. meningitidis isolates and evaluate demographic and other risk factors associated with carriage in adolescents and young adults aged 10-24 y in Turkey.…”

Section: Abstract Adolescents; Meningococci; Meningococcal Vaccines; Nasopharyngeal Colonization; Neisseria Meningitidis; Turkeymentioning

confidence: 99%

See 2 more Smart Citations

The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey

Tekin

Dinleyici

Ceyhan

et al. 2017

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The serogroup epidemiology of invasive meningococcal disease (IMD), which varies considerably by geographic region and immunization schedule, changes continuously. Meningococcal carriage data are crucial for assessing IMD epidemiology and designing f potential vaccination strategies. Meningococcal seroepidemiology in Turkey differs from that in other countries: serogroups W and B are the predominant strains for IMD during childhood, whereas no serogroup C cases were identified over the last 10 y and no adolescent peak for IMD was found. There is a lack of data on meningococcal carriage that represents the whole population. The aims of this multicenter study (12 cities in Turkey) were to evaluate the prevalence of Neisseria meningitidis carriage, the serogroup distribution and the related risk factors (educational status, living in a dormitory or student house, being a household contact with Hajj pilgrims, smoking, completion of military service, attending bars/clubs) in 1518 adolescents and young adults aged 10-24 y. The presence of N. meningitidis DNA was tested, and a serogroup analysis was performed using polymerase chain reaction. The overall meningococcal carriage rate was 6.3% (n = 96) in the study population. A serogroup distribution of the 96 N. meningitidis strains isolated from the nasopharyngeal specimens revealed serogroup A in 5 specimens (5.2%), serogroup B in 9 specimens (9.4%), serogroup W in 64 specimens (66.6%), and serogroup Y in 4 specimens (4.2%); 14 were classified as non-grouped (14.4%). No serogroup C cases were detected. The nasopharyngeal meningococcal carriage rate was 5% in the 10-14 age group, 6.4% in the 15-17 age-group, and 4.7% in the 18-20 age group; the highest carriage rate was found in the 21-24 age group (9.1%), which was significantly higher than those of the other age groups (p < 0.05). The highest carriage rate was found in 17-year-old adolescents (11%). The carriage rate was higher among the participants who had had close contact with Hajj/Umrah pilgrims (p < 0.01) or a history of upper respiratory tract infections over the past 3 months (p < 0.05). The nasopharyngeal carriage rate was 6.3% among adolescents and young adults in Turkey and was similar to the recent rates observed in the same age groups in other countries. The most prevalent serogroup was W, and no serogroup C cases were found. In conclusion, the present study found that meningococcal carriage reaches its peak level by age 17, the highest carriage rate was found in 21 - to 24 - year-olds and the majority of the carriage cases were due to serogroup W. Adolescents and young adult carriers seem to be a potential reservoir for the disease, and further immunization strategies, including adolescent immunization, may play a role in the control of IMD.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Abstract Adolescents; Meningococci; Meningococcal Vaccines; Nasopharyngeal Colonization; Neisseria Meningitidis; Turkeymentioning

confidence: 99%

See 1 more Smart Citation

The prevalence, serogroup distribution and risk factors of meningococcal carriage in adolescents and young adults in Turkey

Tekin

Dinleyici

Ceyhan

et al. 2017

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

show abstract

“…Mevcut konjuge aşıların [Haemophilus influenzae tip B (Hib), Streptococcus pneumoniae ve N.meningitidis] kullanımı ile bakteriyel menenjitin etyolojik sebepleri büyük ölçüde değişmiştir 3,4 . Hib ve S.pneumoniae'ya karşı konjuge aşılar Ulusal Aşı Takvimimize girdikten sonra Hib kaynaklı menenjit olgusu 2012 yılından itibaren görülmemekte, S.pneumoniae kaynaklı menenjit olgusu ise oldukça azalmış olup, N.meningitidis önde gelen etken olarak karşımıza çıkmaktadır.…”

Section: Olgu Sunumuunclassified

“…2005 yılından önce Türkiye'de invaziv meningokokal hastalık için epidemiyolojik çalışma ve takip yapılmamış olup, serogruplar belirlenmemiştir. Yapılmaya başlayan sürveyans ile hastalık yapan serogrupların yıllar içinde değişkenlik gösterdiği görülmektedir 3 . Bu çalışmada, son yıllarda ülkemizde nadir görülen serogrup C ve serogrup Y meningokoksemisi görülen iki olgu sunulmuştur.…”

Section: Introductionunclassified