Review of Keloid Patients with Clinical Experience

Abstract

Background Keloid management can be difficult and frustrating, and the mechanisms underlying keloid formation are only partially understood. Despite many studies of the pathogenesis and cause, little is known of the predisposing factors or the diathesis. Therefore, we evaluated patients with keloid for 13 years clinical experience, with the goal of considering the causative factors and physical disposition of keloid. Methods We evaluated 107 patients (38 males, 69 females; median age 22.31 years, range 7-58 years) who visited the department of plastic and reconstructive surgery from March 1998 to December 2010. The patients' chart and clinical photo were reviewed for the study. Results Etiologies were an intended wound like piercing or surgical wound (n =39), avulsion flap injury (n=30), laceration (n=29) and burn (n=9). The location were the head and neck (n=38), trunk (n=23), upper extremity (n=21), lower extremity (n=16) and face (n =9). Patients with more than overweight (>23 kg/m 2 , Body mass index) were 84 in 107 patients (78.5%) with keloids. Conclusions In the care of the keloids, patient information, particularly sex, age and body mass index, it may be useful indicators for expecting prognosis of the patients and treating with proper management. Particularly, large-scale accurate follow-up observations on obese patients will be critical.

Epigenetic Influences on Wound Healing and Hypertrophic-Keloid Scarring: A Review for Basic Scientists and Clinicians

“…In that regard, obese rats appear to have weaker skin than normal-weight rats; i.e., a less tensile force due to the failure of collagen accumulation at the wound site [ 78 ]. There are also serious circulation changes linked to obesity that may lead to the increased incidence of keloid formation wherein slowing of blood flow to a wound site impairs wound healing, thereby increasing susceptibility to keloids [ 79 ], possibly by an ischemic mechanism.…”

Case series of keloid wedge resection in the ear: a focus on aesthetic aspects

“…It is believed that genetic susceptibility, environmental factors, and several patient characteristics interact in a complex manner to cause the development of keloids, although the etiology is still unclear [4,5]. The prevalence of keloids tends to be higher in darkskinned racial groups, ranging from 5% to 10% in Africans versus 0.1% in Asians [2].…”