Review of Medicinal Plants and their Compounds for Aldose Reductase Inhibitory Activity

Bouknana, Saliha; Ouassou, Hayat; Bnouham, Mohamed

doi:10.2174/1570180814666171011163954

Cited by 2 publications

(1 citation statement)

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“…Bulgarian traditional medicine recommends tens of herbs to assist diabetes management; their effects are most often related to a reduction in blood glucose or stimulation of insulin secretion [4]. Several metabolic pathways involved in the development of diabetes have been proposed as targets of medicinal plants; among them are the inhibition of starch-hydrolyzing enzymes α-amylase and α-amyloglucosidase [5], inhibition of dipeptidyl peptidase-IV [6], activation of peroxisome proliferator-activated receptors-γ (PPAR-γ) [7], reduction in osmotic Plants 2024, 13, 1406 2 of 12 stress through inhibition of aldose reductase [8], or combination of several mechanisms [9]. Apart from these possible mechanisms, diabetes is accompanied by oxidative stress and an increase in reactive oxygen species that can have a deleterious effect on many cells, tissues, and organs [10].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Effects of Extracts Obtained from Endemic Betonica bulgarica Degen and Neič

Slavova,

Genisheva,

Angelova

et al. 2024

Plants

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The increasing prevalence of diabetes mellitus, together with the limited access of many patients to conventional antidiabetic drugs and the side effects resulting from their use, are the reason for the ever-increasing need for new agents. One of the most important strategies used in the therapy of this disease is to reduce the postprandial blood glucose level by inhibiting the carbohydrate-degrading enzymes α-amylase and α-glucosidase. The purpose of the present study was to provide in vitro evidence for the potential hypoglycemic effect of leaf and inflorescence aqueous extracts of Bulgarian endemic species Betonica bulgarica Degen and Neič. Total phenolic and flavonoid contents and antioxidant activities were determined by spectrophotometric methods. Qualitative and quantitative determinations of principal phenolic acids and flavonoids were performed using HPLC with a dual absorbance detector. The plant extracts were able to retard the enzymatic breakdown of starch to glucose with 50% inhibiting concentrations of 1.86 mg/mL and 1.54 mg/mL respectively for leaf and flower extract. Some of the plant constituents are proven inhibitors of α-amylase and/or α-glucosidase, but their adsorption on starch seems to be one additional mechanism for the inhibition of glucose release. Combination index analysis carried out with binary mixtures of acarbose and plant extracts showed a tendency toward synergism with an increase in concentrations and level of inhibition.

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