Review of micro/nanofluidic particle separation mechanisms: Toward combined multiple physical fields for nanoparticles

Lee, Kyunghun; Mishra, Rahul; Kim, Taesung

doi:10.1016/j.sna.2023.114688

Cited by 9 publications

(3 citation statements)

References 144 publications

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“…In fact, if the temporal dependence of the temperature increase for the dispersions is affected by the migration of the UCNPs in and out of the excitation cylinder, this could lead to a novel approach to measure the Soret coefficient, S T , of NPs, which is relevant to opto-thermophoresis, particle separation, and related effects. 72,73 For instance, at steady-state conditions, the concentration profile of the NPs is described as 74–76 where c ( r ) and T ( r ) are the concentration of the NPs and the temperature at a radial distance r from the excitation cylinder, c 0 and T 0 are the concentration of the NPs and the temperature at bulk. The normalized concentration c ( r )/ c 0 can be obtained by probing the UCNPs at a distance r with a laser and determining the ratio of the integrated upconversion emission to that at the bulk.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles

Gonçalves,

Bastos,

Ribeiro

et al. 2024

Nanoscale Adv.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles

Gonçalves,

Bastos,

Ribeiro

et al. 2024

Nanoscale Adv.

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“…Selection of specific cells from complex biological samples using microfluidic technologies has been intensively studied over the past decades, and many new principles for continuous cell sorting have been devised. − The sorting targets of biological samples subjected to microfluidics are not limited to cells but vary from submicrometer-sized extracellular vesicles to large cell clusters or living organisms. Representative applications of microfluidic cell sorters include the detection of rare cells as disease markers, , sorting of highly potent stem cells, , and subpopulation characterization of specific cell populations .…”

Section: Introductionmentioning

confidence: 99%

High-Density Microporous Drainage-Integrating Sheath Flow Generator for Streamlining Microfluidic Cell Sorting Systems

Hayashi,

Hemmi,

Saito

et al. 2024

Anal. Chem.

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Tremendous efforts have been made to develop practical and efficient microfluidic cell and particle sorting systems; however, there are technological limitations in terms of system complexity and low operability. Here, we propose a sheath flow generator that can dramatically simplify operational procedures and enhance the usability of microfluidic cell sorters. The device utilizes an embedded polydimethylsiloxane (PDMS) sponge with interconnected micropores, which is in direct contact with microchannels and seamlessly integrated into the microfluidic platform. The high-density micropores on the sponge surface facilitated fluid drainage, and the drained fluid was used as the sheath flow for downstream cell sorting processes. To fabricate the integrated device, a new process for sponge-embedded substrates was developed through the accumulation, incorporation, and dissolution of PMMA microparticles as sacrificial porogens. The effects of the microchannel geometry and flow velocity on the sheath flow generation were investigated. Furthermore, an asymmetric lattice-shaped microchannel network for cell/particle sorting was connected to the sheath flow generator in series, and the sorting performances of model particles, blood cells, and spiked tumor cells were investigated. The sheath flow generation technique developed in this study is expected to streamline conventional microfluidic cell-sorting systems as it dramatically improves versatility and operability.

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Microfluidic Nanoparticle Separation for Precision Medicine

Lan,

Chen,

Zou

et al. 2024

Advanced Science

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A deeper understanding of disease heterogeneity highlights the urgent need for precision medicine. Microfluidics, with its unique advantages, such as high adjustability, diverse material selection, low cost, high processing efficiency, and minimal sample requirements, presents an ideal platform for precision medicine applications. As nanoparticles, both of biological origin and for therapeutic purposes, become increasingly important in precision medicine, microfluidic nanoparticle separation proves particularly advantageous for handling valuable samples in personalized medicine. This technology not only enhances detection, diagnosis, monitoring, and treatment accuracy, but also reduces invasiveness in medical procedures. This review summarizes the fundamentals of microfluidic nanoparticle separation techniques for precision medicine, starting with an examination of nanoparticle properties essential for separation and the core principles that guide various microfluidic methods. It then explores passive, active, and hybrid separation techniques, detailing their principles, structures, and applications. Furthermore, the review highlights their contributions to advancements in liquid biopsy and nanomedicine. Finally, it addresses existing challenges and envisions future development spurred by emerging technologies such as advanced materials science, 3D printing, and artificial intelligence. These interdisciplinary collaborations are anticipated to propel the platformization of microfluidic separation techniques, significantly expanding their potential in precision medicine.

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Review of micro/nanofluidic particle separation mechanisms: Toward combined multiple physical fields for nanoparticles

Cited by 9 publications

References 144 publications

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles

High-Density Microporous Drainage-Integrating Sheath Flow Generator for Streamlining Microfluidic Cell Sorting Systems

Microfluidic Nanoparticle Separation for Precision Medicine

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Review of micro/nanofluidic particle separation mechanisms: Toward combined multiple physical fields for nanoparticles

Cited by 9 publications

References 144 publications

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF4:Yb/Er upconverting nanoparticles

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF4:Yb/Er upconverting nanoparticles

High-Density Microporous Drainage-Integrating Sheath Flow Generator for Streamlining Microfluidic Cell Sorting Systems

Microfluidic Nanoparticle Separation for Precision Medicine

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Product

Resources

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Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles

Thermal properties of nanofluids using hydrophilic and hydrophobic LiYF₄:Yb/Er upconverting nanoparticles