Review of MRI positioning devices for guiding focused ultrasound systems

Yiallouras, Christos; Damianou, Christakis

doi:10.1002/rcs.1601

Cited by 26 publications

(14 citation statements)

References 77 publications

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“…Magnetic resonance thermometry does image the treatment area much better for this type of HIFU. Magnetic resonance guidance has advantages over US, particularly superior depiction of anatomic detail . Magnetic resonance thermometry depicts the changes that occur within hydrogen atoms when they are subjected to heat.…”

Section: Magnetic Resonance Versus Us Guidance For Hifumentioning

confidence: 99%

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Dubinsky

Khokhlova

et al. 2019

J of Ultrasound Medicine

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This article reviews the most current methods and technological aspects of highintensity focused ultrasound (HIFU), which is termed histotripsy. The rationale for focal therapy for prostate carcinoma rather than prostatectomy, which is being used extensively throughout Europe and Asia, is presented, and an argument for why HIFU is the modality of choice for primary therapy and recurrent disease is offered. The article presents a review of the technical advances including higher ultrasound beam energy than current thermal HIFU which allows for more accurate tissue targeting, less collateral tissue damage, and faster treatment times. Finally, the article presents a discussion about the advantage of ultrasound guidance for histotripsy in preference to magnetic resonance imaging guidance primarily based on cost, ease of application, and portability.

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Section: Magnetic Resonance Versus Us Guidance For Hifumentioning

confidence: 99%

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Dubinsky

Khokhlova

et al. 2019

J of Ultrasound Medicine

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“…Today, tools tailored for different organs and clinical situations are available; brain, breast, prostate, abdominal organs and bone are approached by using different devices in order to achieve the best comfort and positioning of the patient as well as to obtain an effective FUS therapy. 23 Currently, the first manufacturer in the MRgFUS field is InSightec with ExAblate series, followed by Philips Medical Systems (Eindhoven, Netherlands) with Sonoalleve. Advanced software interfaces have been developed and can be used in clinical practice in order to optimize the treatment plan and to improve the operator interaction and confidence with the system; furthermore, several additional tools currently contribute to enhance the safety and control of the procedure.…”

Section: Mri-guided Focused Ultrasound Surgery Principles and Technomentioning

confidence: 99%

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Bazzocchi¹,

Napoli²,

Sacconi³

et al. 2016

BJR

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MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice. Both the imaging and therapeutic sides of the equipment are based on non-ionizing energy. This technique is a very promising option as potential treatment for several pathologies, including musculoskeletal (MSK) disorders. Apart from clinical applications, MRgFUS technology is the result of long, heavy and cumulative efforts exploring the effects of ultrasound on biological tissues and function, the generation of focused ultrasound and treatment monitoring by MRI. The aim of this article is to give an updated overview on a "new" interventional technique and on its applications for MSK and allied sciences

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“…In addition, with the ability to provide real‐time thermometry feedback, MRI allows for even better‐controlled heat deposition . Therefore, the combination of HIFU and MR guidance is a powerful focal therapy modality for localized prostate cancer . While there are multiple ways to assess treatment outcome, including ultrasound‐measured elasticity and the clinical gold standard of dynamic contrast‐enhanced (DCE) MRI, these methods only delineate coagulated tissues or the lack of perfusion …”

Section: Introductionmentioning

confidence: 99%

Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized ¹³C dual‐agent imaging of metabolism and perfusion

et al. 2018

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The goal of the study was to establish early hyperpolarized (HP) C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent ( C pyruvate and C urea) C MRI/multiparametric H MRI approach was used to measure prostate cancer metabolism and perfusion 3-4 h, 1 d, and 5 d after exposure to ablative and sub-lethal doses of HIFU within adenocarcinoma of mouse prostate tumors using a focused ultrasound applicator designed for murine studies. Pathologic and immunohistochemical analysis of the ablated tumor demonstrated fragmented, non-viable cells and vasculature consistent with coagulative necrosis, and a mixture of destroyed tissue and highly proliferative, poorly differentiated tumor cells in tumor tissues exposed to sub-lethal heat doses in the ablative margin. In ablated regions, the intensity of HP C lactate or HP C urea and dynamic contrast-enhanced (DCE) MRI area under the curve images were reduced to the level of background noise by 3-4 h after treatment with no recovery by the 5 d time point in either case. In the tissues that received sub-lethal heat dose, there was a significant 60% ± 12.4% drop in HP C lactate production and a significant 30 ± 13.7% drop in urea perfusion 3-4 h after treatment, followed by recovery to baseline by 5 d after treatment. DCE MRI K showed a similar trend to HP C urea, demonstrating a complete loss of perfusion with no recovery in the ablated region, while having a 40%-50% decrease 3-4 h after treatment followed by recovery to baseline values by 5 d in the margin region. The utility of the HP C MR measures of perfusion and metabolism in optimizing focal HIFU, either alone or in combination with adjuvant therapy, deserves further testing in future studies.

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Review of MRI positioning devices for guiding focused ultrasound systems

Abstract: Existing MRgFUS systems have been utilized mostly in oncology (fibroids, brain, liver, kidney, bone, pancreas, eye, thyroid, and prostate). It is anticipated that, in the near future, there will be a positioning device for every organ that is accessible by focused ultrasound.

Cited by 26 publications

References 77 publications

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized ¹³C dual‐agent imaging of metabolism and perfusion

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Review of MRI positioning devices for guiding focused ultrasound systems

Abstract: Existing MRgFUS systems have been utilized mostly in oncology (fibroids, brain, liver, kidney, bone, pancreas, eye, thyroid, and prostate). It is anticipated that, in the near future, there will be a positioning device for every organ that is accessible by focused ultrasound.

Cited by 26 publications

References 77 publications

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13C dual‐agent imaging of metabolism and perfusion

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Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized ¹³C dual‐agent imaging of metabolism and perfusion