Review of mycotoxin‐detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety

Boudergue, Caroline; Burel, Christine; Dragacci, Sylviane; Favrot, Marie‐Christine; Frémy, J. M.; Massimi, Claire; Prigent, Philippe; Debongnie, Philippe; Pussemier, Luc; Boudra, Hamid; Morgavi, Diego; Oswald, Isabelle P.; Pérez, A. Soriano; Avantaggiato, Giuseppina

doi:10.2903/sp.efsa.2009.en-22

Cited by 138 publications

(185 citation statements)

References 250 publications

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“…Despite the many publications on biological transformation of mycotoxins by microorganisms, their application in practice in detoxification of animal feeds has been limited. This may be due to lack of information about mechanisms of transformation, toxicity of transformation products, effects of the transformation reactions on nutritional values of the feeds, and safety toward animals (Boudergue et al, 2009).…”

Section: Additives As Detoxifying Agentsmentioning

confidence: 99%

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Escrivá

Font

Manyes

2015

Food and Chemical Toxicology

310

203

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Section: Additives As Detoxifying Agentsmentioning

confidence: 99%

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Escrivá

Font

Manyes

2015

Food and Chemical Toxicology

310

203

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“…Mycotoxicoses correspond mainly to diet contamination with aflatoxin or deoxynivalenol, which are known to affect feed intake and can even lead to anorexia for higher doses of mycotoxins (Boudergue et al, 2009). The time of the recovery period, corresponding to the time between the immediate reduction and the constant reduction in ADFI (i.e.…”

Section: Consequences Of Immune Challenges On Feed Intakementioning

confidence: 99%

Meta-analysis of feed intake and growth responses of growing pigs after a sanitary challenge

Pastorelli

Milgen

Lovatto

et al. 2012

Animal

108

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Sanitary challenges negatively affect feed intake and growth, leading to a negative impact on animal well-being and economic losses. The aim of this study was to carry out a meta-analysis to quantify the dynamic feed intake and growth responses of growing pigs after a sanitary challenge. A database was constructed using 122 published experiments reporting the average daily feed intake (ADFI) and the average daily gain (ADG) of pigs subjected to one of six sanitary challenges: digestive bacterial infections, poor housing conditions, lipopolysaccharide (LPS) challenges, mycotoxicoses, parasitic infections and respiratory diseases. The responses to experimental challenges were calculated relative to that of a control group. Statistical analyses were carried out for each challenge to quantify the mean and the dynamic responses in feed intake and growth and to identify the basis of the reduction in growth (i.e. reduction in feed intake or reduction in feed efficiency related to changes in maintenance requirements). All challenges resulted in a reduction in ADFI and ADG, with the strongest responses for mycotoxicoses, respiratory diseases and digestive bacterial infections (8% to 23% reduction in ADFI and 16% to 29% reduction in ADG). The reduction in ADG was linearly related to the reduction in ADFI for digestive bacterial infections, LPS challenge, parasitic infections and respiratory diseases. For poor housing conditions and mycotoxicoses, the relationship was curvilinear. A 10% reduction in ADFI resulted in a reduction in ADG varying from 10% for mycotoxicoses to 43% for digestive bacterial infections. More than 70% of the reduction in ADG could be explained by the reduction in ADFI for mycotoxicoses, LPS challenge and respiratory diseases. For challenges associated with the gastrointestinal tract, a large part of the reduction in ADG was due to an increase in maintenance requirements, suggesting digestive and metabolic changes. A dynamic pattern in the reduction in feed intake and growth rate could be identified for digestive bacterial infections, mycotoxicoses and respiratory diseases. For digestive bacterial infections and mycotoxicoses, pigs did not fully recover from the challenge during the experimental period. The results of this study can be used to quantify the effects of a sanitary challenge in growth models of pigs.Keywords: meta-analysis, pigs, feed intake, growth, sanitary challenge Implications Diseases negatively affect feed intake and growth in pigs. This often results in a decrease in feed efficiency, an increase in production costs (e.g. feed and veterinary costs) and an increase in nutrient excretion and in environmental impact. Medication and/or feed additives are often used to limit the negative consequences of diseases. However, the development of sustainable pig production systems requires reducing the use of medication and feed additives. The ability to predict the performance of pigs under a wide range of sanitary challenges allows using management and feeding strategies to minimize the ne...

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“…Biotransformation of the biologically and economically most important mycotoxins by microorganisms has been well-documented and reviewed (Boudergue et al 2009;Halász et al 2009). In some cases, biotransformation leads to less toxic or non-toxic products and is considered to be a detoxification (He et al 2010;Karlovsky 1999;Wu et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Two rapid assays for screening of patulin biodegradation

Wright

Felice

Ianiri

et al. 2013

Int. J. Environ. Sci. Technol.

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The mycotoxin patulin is produced by the blue mould pathogen Penicillium expansum in rotting apples during postharvest storage. Patulin is toxic to a wide range of organisms, including humans, animals, fungi and bacteria. Wash water from apple packing and processing houses often harbours patulin and fungal spores, which can contaminate the environment. Ubiquitous epiphytic yeasts, such as Rhodosporidium kratochvilovae strain LS11 which is a biocontrol agent of P. expansum in apples, have the capacity to resist the toxicity of patulin and to biodegrade it. Two non-toxic products are formed. One is desoxypatulinic acid. The aim of the work was to develop rapid, high-throughput bioassays for monitoring patulin degradation in multiple samples. Escherichia coli was highly sensitive to patulin, but insensitive to desoxypatulinic acid. This was utilized to develop a detection test for patulin, replacing time-consuming thin layer chromatography or high-performance liquid chromatography. Two assays for patulin degradation were developed, one in liquid medium and the other in semi-solid medium. Both assays allow the contemporary screening of a large number of samples. The liquid medium assay utilizes 96-well microtiter plates and was optimized for using a minimum of patulin. The semisolid medium assay has the added advantage of slowing down the biodegradation, which allows the study and isolation of transient degradation products. The two assays are complementary and have several areas of utilization, from screening a bank of microorganisms for biodegradation ability to the study of biodegradation pathways.

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Review of mycotoxin‐detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety

Cited by 138 publications

References 250 publications

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Meta-analysis of feed intake and growth responses of growing pigs after a sanitary challenge

Two rapid assays for screening of patulin biodegradation

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