Review of Narcolepsy and Other Common Sleep Disorders in Children

Nallu, Sagarika; Guerrero, Giselle Y.; Lewis-Croswell, Jaclyn L.; Wittine, Lara

doi:10.1016/j.yapd.2019.03.008

Cited by 3 publications

(4 citation statements)

References 44 publications

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“…2 Cataplexy, defined as an abrupt, brief episode of loss of voluntary muscle tone, with consciousness retained, is only present in type 1. [1][2][3] This feature is observed in 60%-70% of these patients, being the most typical symptom, 2 and it is usually triggered by strong emotions, mostly laughter. 1 Cataplexy can be present concomitantly with EDS or within 1-3 years.…”

Section: Descriptionmentioning

confidence: 99%

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Typical case of narcolepsy in paediatrics

et al. 2021

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Section: Descriptionmentioning

confidence: 99%

“…4 However, more complex movement disturbances, such as perioral movements, can be present. [1][2][3] Children with narcolepsy may also develop hyperactivity, aggressiveness, distractibility and restlessness. Rapid weight gain and precocious puberty are frequent.…”

Section: Descriptionmentioning

confidence: 99%

Typical case of narcolepsy in paediatrics

et al. 2021

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“…Cataplexy refers to an abrupt but brief (<2 minutes) loss or decrease of voluntary skeletal muscle tone with retained consciousness precipitated by strong emotions, such as anger, laughter, joy, elation, or surprise [65][66][67] . It is estimated to be present in 65% to 75% of patients with narcolepsy 68,69 and is the most specific symptom of narcolepsy type I.…”

Section: Epilepsy Versus Select Sleep-related Movement Disordersmentioning

confidence: 99%

Sleep and Epilepsy, Clinical Spectrum and Updated Review

Avidan²,

Engel³

2021

Sleep Medicine Clinics

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Among the epilepsy syndromes, self-limited epilepsy with centrotemporal spikes and Panayiotopoulos syndrome have seizures that occur more often during sleep whereas seizures associated with juvenile myoclonic epilepsy (JME) occur in general within 2 hours of awakening. Disturbed sleep as manifested by reduced sleep efficiency and decreased percentage of slow wave sleep commonly is found in patients with Lennox-Gastaut syndrome as well as focal epilepsy. Non-rapid eye movement parasomnia preferentially arise out of stage N3, do not manifest with hyperkinetic automatism, are not stereotyped, and are much less frequent compared with seizures associated with sleep-related hypermotor epilepsy. Blowing, deep inspiration, sniffling, coughing, and changes in respiratory rate and volume were seen more often with seizures than with rapid eye movement sleep behavior disorder (RBD), whereas dream recollection is more suggestive of RBD.

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“…It has been hypothesized to be caused by a combination of genetic and environmental factors, trigger an autoimmune process that results in hypothalamic destruction, with a loss of hypocretin-1-containing cells, causing the hypocretin deficiency (4,5). Psychiatric comorbidities with narcolepsy are frequent, and include mood, anxiety, attention deficit hyperactivity, eating disorders, and psychosis (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of Narcolepsy and Psychotic Disorders: A Nationwide Population-Based Study in Taiwan

et al. 2020

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Background: Narcolepsy is a chronic sleep disorder that is likely to have neuropsychiatric comorbidities. Psychotic disorders are characterized by delusion, hallucination, and reality impairments. This study investigates the relationship between narcolepsy and psychotic disorders. Design and Methods: This study involves patients who were diagnosed with narcolepsy between January 2002 and December 2011 (n = 258) and age-and gender-matched controls (n = 2580) from Taiwan's National Health Insurance database. Both the patients and the controls were monitored from January 1, 2002 to December 31, 2011 to identify any occurrence of a psychotic disorder. Drugs that have been approved for treating narcolepsy: immediate-release methylphenidate (IR-MPH), osmotic controlled-release formulations of methylphenidate (OROS-MPH), and modafinil, were analyzed. A multivariate logistic regression model was used to evaluate the potential comorbidity of narcolepsy with psychotic disorders. Results: During the study period, 8.1% of the narcoleptic patients exhibited comorbidity with a psychotic disorder, whereas only 1.5% of the control subjects (1.5%) had psychotic disorders (aOR, 4.07; 95% CI, 2.21-7.47). Of the narcolepsy patients, 41.5, 5.4, and 13.2% were treated with MPH-IR, MPH-OROS, and modafinil, accordingly. Pharmacotherapy for narcolepsy did not significantly affect the risk of exhibiting a psychotic disorder. Conclusions: This nationwide study revealed that narcolepsy and psychotic disorders commonly co-occur. Pharmacotherapy for narcolepsy was not associated with the risk of psychotic disorders. Our findings serve as a reminder that clinicians must consider the comorbidity of narcolepsy and psychosis.

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Review of Narcolepsy and Other Common Sleep Disorders in Children

Cited by 3 publications

References 44 publications

Typical case of narcolepsy in paediatrics

Typical case of narcolepsy in paediatrics

Sleep and Epilepsy, Clinical Spectrum and Updated Review

Comorbidity of Narcolepsy and Psychotic Disorders: A Nationwide Population-Based Study in Taiwan

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