Review of neurotoxicity of T-2 toxin

Wang, Youshuang; Wang, Bo; Wang, Peilin; Hua, Zeao; Zhang, Shanshan; Wang, Xuebing; Yang, Xu; Zhang, Cong

doi:10.1007/s12550-024-00518-5

Cited by 5 publications

(1 citation statement)

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“…The consumption of T-2-contaminated food and drinking water can lead to acute or chronic poisoning in animals and humans. T-2 toxin poisoning affects the digestive system, immune system, blood system, nervous system, reproductive system, and skeletal system. , Acute T-2 toxin poisoning leads to emesis, anorexia, diarrhea, gastritis, hypocytosis, and other clinical symptoms . Chronic poisoning can also cause growth inhibition and immune injury in animals.…”

Section: Introductionmentioning

confidence: 99%

Overview of T-2 Toxin Enterotoxicity: From Toxic Mechanisms and Detoxification to Future Perspectives

Zhang,

Song,

Hua

et al. 2024

J. Agric. Food Chem.

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Fusarium species produce a secondary metabolite known as T-2 toxin, which is the primary and most harmful toxin found in type A trichothecenes. T-2 toxin is widely found in food and grain-based animal feed and endangers the health of both humans and animals. T-2 toxin exposure in humans and animals occurs primarily through food administration; therefore, the first organ that T-2 toxin targets is the gut. In this overview, the research progress, toxicity mechanism, and detoxification of the toxin T-2 were reviewed, and future research directions were proposed. T-2 toxin damages the intestinal mucosa and destroys intestinal structure and intestinal barrier function; furthermore, T-2 toxin disrupts the intestinal microbiota, causes intestinal flora disorders, affects normal intestinal metabolic function, and kills intestinal epidermal cells by inducing oxidative stress, inflammatory responses, and apoptosis. The primary harmful mechanism of T-2 toxin in the intestine is oxidative stress. Currently, selenium and plant extracts are mainly used to exert antioxidant effects to alleviate the enterotoxicity of T-2 toxin. In future studies, the use of genomic techniques to find upstream signaling molecules associated with T-2 enterotoxin toxicity will provide new ideas for the prevention of this toxicity. The purpose of this paper is to review the progress of research on the intestinal toxicity of T-2 toxin and propose new research directions for the prevention and treatment of T-2 toxin toxicity.

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Section: Introductionmentioning

confidence: 99%