Review of occupational lung carcinogens

Steenland, Kyle; Loomis, Dana; Shy, Carl M.; Simonsen, Neal

doi:10.1002/(sici)1097-0274(199605)29:5<474::aid-ajim6>3.0.co;2-m

Cited by 168 publications

(98 citation statements)

References 16 publications

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“…Although most lung cancer is related to tobacco use, it is ranked second only to bladder cancer in the proportion of cases thought to be due to occupational exposures (Steenland et al, 1996). Chromosomal deletion of 8p21-22 is one of the most common findings in cytogenetic studies and loss of heterozygosity (LOH) analysis in NSCLC (Niklinski et al, 2001;Pei et al, 2001;Minna et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Chromosomal deletion of 8p21-22 is one of the most common findings in cytogenetic studies and loss of heterozygosity (LOH) analysis in NSCLC (Niklinski et al, 2001;Pei et al, 2001;Minna et al, 2002). Different risk factors for human NSCLC, such as cigarette smoking or exposure to occupational carcinogens (Steenland et al, 1996), possess the ability to induce either genomic deletion or aberrant DNA methylation . Therefore, DLC-1 may be a target of these risk factors in human lung cancer.…”

Section: Introductionmentioning

confidence: 99%

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DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

et al. 2003

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The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth. Given the high frequency of deletion involving region 8p21-22 in human non-small cell lung carcinoma (NSCLC), we examined alterations of DLC-1 in a series of primary tumors and tumor cell lines and tested effects of DLC-1 on tumor cell growth. A significant decrease or absence of the DLC-1 mRNA expression was found in 95% of primary NSCLC (20/21) and 58% of NSCLC cell lines (11/19). Transcriptional silencing of DLC-1 was primarily associated with aberrant DNA methylation, rather than genomic deletion as 5-aza-2 0 -deoxycytidine induced reactivation of DLC-1 expression in 82% (9/11) NSCLC cell lines showing downregulated DLC-1. It was further evidenced by an aberrant DLC-1 promoter methylation pattern, which was detected by Southern blotting in 73% (8/11) of NSCLC cell lines with downregulation of the gene. The transfer of DLC-1 into three DLC-1 negative cell lines caused a significant inhibition in cell proliferation and/or a decrease in colony formation. Furthermore, stable transfer of DLC-1 abolished tumorigenicity in nude mice of two cell lines, suggesting that DLC-1 plays a role in NSCLC by acting as a bona fide new tumor suppressor gene.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

et al. 2003

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“…Similar findings reported from mainland China, Hong Kong and Singapore showed significant relationships between smoking habit and lung cancer [10, 45,56]. At present, many occupations, industries, and specific chemical substances have been associated with a well established or suspected excess risk of lung cancer [57,58].…”

Section: Discussionmentioning

confidence: 99%

Knowledge and Practice towards Lung Cancer among University Students

Al-Naggar¹

2012

J Community Med Health Edu

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Objective: The objective of this study was to determine the knowledge and practice towards lung cancer among university students.Methodology: Cross-sectional study was conducted among Management and Science University students (MSU). Two hundred and thirteen students were selected randomly from all faculties. The data were collected from the lectures halls, library and university café. Data analysis was conducted using SPSS version 13, t-test was used for univariate analysis. Multiple linear regressions were used for multivariate analysis.Results: A total number of 213 university students participated in this study. The majority of them females, 22 years old and younger, Malays, single, from non-medical schools and with family monthly income 3000 Ringgit Malaysia (RM) and less (57.3%, 65.3%, 78.4%, 97.2%, 55.9%, 59.6%, and 66.7%; respectively). The majority of the participants mentioned that they knew about lung cancer (93%). Regarding the knowledge about risk factors towards lung cancer, they knew that the risk factors of lung cancer are: smoking (100%), eating chili and deep fried food (68.5%), air pollution (89.2%), alcohol (75.6%), occupational hazard (75.6%), passive smoking (90.1%), exercise reduce the risk of lung cancer (83.1%) and lung cancer is inherited (51.6%). Regarding the practice towards lung cancer prevention, the majority of the participants mentioned that they are not smokers neither alcohol drinkers (90.1%, 94.8%; respectively). Regarding the factors associated with knowledge about lung cancer, marital status, type of faculty, and type of semester significantly influence the knowledge of university students (p=0.014, p=0.001, p=0.028; respectively) in univariate analysis. For multivariate analysis, only types of faculty significantly influence the knowledge of the university students towards lung cancer (p=0.001). Conclusion:The university students had good knowledge about risk factors. Types of faculty significantly influence the knowledge of the university students towards lung cancer.

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“…(6) Exposure to asbestos, alone, is estimated to be responsible for at least half of the cases of lung cancer attributable to occupation. (7,8) Recently, the Brazilian National Ministry of Health issued a decree making it mandatory that cases of occupational lung cancer be reported. (9) The Social Security Regulation-Decree 3048/99, amended by Decree no.…”

Section: Occupational Agents Related To Lung Cancermentioning

confidence: 99%

Câncer de pulmão ocupacional

2010

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The principal risk factor for lung cancer is smoking, which is largely responsible for the development of the disease in men and women. It is estimated that 10-15% of all deaths from lung cancer in the USA are caused by risk factors other than smoking. In isolation, these would account for 16,000-24,000 deaths per year, which would still place lung cancer among the ten most deadly forms of cancer.(3) Occupational carcinogens can act alone or in synergy with smoking. A review of lung cancer in Brazil discussed the principal risk factors, notably smoking, and the economic sectors where carcinogens are strongly present. The economic sectors listed included IntroductionCarcinogens are often found in the workplace. Until the 1970s, most of the known human carcinogens were encountered in the workplace. The work environment remains a significant source of carcinogens.( 1) Carcinogenesis is a multifactorial process in which there is interaction among hereditary, genetic, and environmental factors that lead to uncontrolled cell growth. From this standpoint, occupational cancer is not considered a typical occupational disease, but rather a disease in which work, as an environmental factor, plays a decisive pathogenic role, by Schilling's criteria, which will be discussed below. AbstractLung cancer is a multifactorial disease. Hereditary, genetic, and environmental factors interact in its genesis. The principal risk factor for lung cancer is smoking. However, the workplace provides an environment in which there is a risk of exposure to carcinogens. The International Agency for Research on Cancer currently lists 19 substances/work situations/occupations that have been proven to be associated with lung cancer (group 1). Thorough occupational history taking is not widely practiced in patients with lung cancer, which has a negative impact on the investigation of causality and, consequently, on the identification of cases of occupational cancer. The objectives of this review were to list the agents that are recognized as causes of lung cancer, to discuss the contribution of occupation to the development of the disease, to cite national studies on the subject, and to propose a list of procedures that are essential to the appropriate investigation of causality between lung cancer and occupation.Keywords: Lung neoplasms; Occupational diseases; Occupations; Carcinogens. ResumoO câncer de pulmão é multicausal. Fatores hereditários, genéticos e ambientais interagem na sua gênese. O principal fator de risco é o tabagismo. Entretanto, o ambiente de trabalho é um local de possível exposição a agentes cancerígenos. Atualmente, a International Agency for Research on Cancer lista 19 substâncias/situações de trabalho/ocupações comprovadamente associadas ao câncer de pulmão (grupo 1). A abordagem da ocupação em pacientes portadores de câncer de pulmão é fraca, impactando negativamente na busca da causalidade e, consequentemente, no desvelamento de casos de câncer ocupacional. Os objetivos desta revisão foram elencar os agentes reconhecidame...

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Review of occupational lung carcinogens

Cited by 168 publications

References 16 publications

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas

Knowledge and Practice towards Lung Cancer among University Students

Câncer de pulmão ocupacional

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