Review of ovarian tissue cryopreservation techniques for fertility preservation

Bahroudi, Zahra; Zarnaghi, Mahsa Rezaei; Izadpanah, M; Abedelahi, Ali; Niknafs, Behrooz; Nasrabadi, Hamid Tayefi; Seghinsara, Abbas Majdi

doi:10.1016/j.jogoh.2021.102290

Cited by 26 publications

(14 citation statements)

References 52 publications

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“…OC is the preferred FP technique for post-pubertal adolescents because it avoids the immediate requirement of a sperm donor and the ethical complications associated with sperm banks for minors. The emerging FP treatments for girls include ovarian tissue cryopreservation [22], in vitro oocyte maturation [23], and new pharmacologic therapies [17].…”

Section: Fertility Preservation Proceduresmentioning

confidence: 99%

Barriers to Oncofertility Care among Female Adolescent Cancer Patients in Canada

Glazer

Schulte

2022

Current Oncology

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High survival rates in adolescent cancer patients have shifted the medical focus to the long-term outcomes of cancer treatments. Surgery, chemotherapy, and radiation increase the risk of infertility and infertility-related distress in adolescent cancer patients and survivors. The aims of this narrative review were to (1) describe the psychosocial impacts of cancer-related infertility in adolescents, (2) identify multilevel barriers to fertility preservation (FP) conversations and referrals, and (3) conclude with evidence-based clinical solutions for improving the oncofertility support available to Canadian adolescents. The results of this review revealed that FP decisions occur within the patient, parent, and health care provider (HCP) triad, and are influenced by factors such as parent attitudes, patient maturity, and HCP knowledge. Decision tools and HCP education can promote the occurrence of developmentally appropriate fertility discussions. At the systems level, cost and resource barriers prevent patients from receiving sufficient fertility information and referrals. Clinical models of care (MOCs) can define interdisciplinary roles and referral pathways to improve the integration of oncofertility services into adolescent cancer care. The continued integration of oncofertility care will ensure that all Canadian adolescents receive the exemplary medical and psychological support necessary to make empowered decisions about their own fertility.

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Section: Fertility Preservation Proceduresmentioning

confidence: 99%

Barriers to Oncofertility Care among Female Adolescent Cancer Patients in Canada

Glazer

Schulte

2022

Current Oncology

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“…In general, the most common techniques for ovarian tissue cryopreservation include vitrification, ultra-rapid freezing and slow freezing [ 74 ]. Variables such as the age of patients and medical condition are keys for the final selection of the optimum technique [ 8 ].…”

Section: Techniques Of Cryopreservationmentioning

confidence: 99%

“…It includes the solidification of the cells of interest in a glass-type form without ice crystallization, made possible through the exposure of the sample to solutions containing high concentrations of cryoprotectant agents and, subsequently, to quick cooling (at cooling rates reaching 5000 °C/min) using liquid nitrogen [ 76 ]. This procedure leads to the vitrification of cells without the formation of ice and its catastrophic effect on cells during cryopreservation [ 8 ]. It should be noted that higher concentrations of cryoprotectant agents are needed in order to avoid both extra- and intra-cellular ice crystals.…”

Section: Techniques Of Cryopreservationmentioning

confidence: 99%

“…Ultra-rapid freezing is a technique that is based on the direct exposure of the sample containers in liquid nitrogen, using lower quantities of cryoprotectant agents than vitrification [ 78 ]. However, this method has mainly been used for oocyte and embryo freezing, rather than ovarian tissue cryopreservation [ 8 ].…”

Section: Techniques Of Cryopreservationmentioning

confidence: 99%

“…Apart from the direct or indirect effect of specific types of cancer on the reproductive system (ovarian, breast, uterine cancer), the aforementioned survival rates come at a cost. Cancer treatments, such as chemotherapy or radiotherapy, have often gonadotoxic effects leading to ovarian failure and infertility [ 7 , 8 ]. Decrease in steroidogenesis as a result of ovarian failure may lead to increased odds of associated diseases, such as hypertension, cardiovascular disease, osteoporosis and menopausal symptoms, as well as the degradation of quality of life and psychological problems and distress [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Ovarian Tissue Cryopreservation in Children and Adolescents

et al. 2022

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Cancer during childhood and adolescence remains a major public health issue, affecting a significant portion of this age group. Although newer anti-cancer treatments have improved survival rates, this comes at a cost in terms of gonadotoxic effects. As a result, the preservation of fertility is important. Ovarian tissue cryopreservation, one of the newest methods, has some advantages, especially for prepubertal patients: no need for ovarian stimulation, thus, no further risk for estrogen-sensitive cancer types, and preservation of more and better-quality primordial follicles of the ovarian cortex. The most frequent indications include treatment with alkylating agents, ovarian-focused radiotherapy, leukemias, lymphomas, brain and neurological tumors, as well as Turner syndrome and benign hemoglobinopathies. An expected survival exceeding 5 years, the absence of systematic disease and an overall risk of premature ovarian insufficiency over 50% are among the criteria that need to be fulfilled in order for a patient to undertake this method. Orthotopic transplantation is more frequently used, since it can allow both live birth and the recovery of endocrine function. Reimplantation of malignant cells is always a major risk and should always be taken into consideration. Histological analysis, as well as immunohistochemical and molecular methods, are needed in order to improve the search for malignant cells before transplantation. Ovarian tissue cryopreservation appears to be a method with specific benefits, indications and risks which can be an important tool in terms of preserving fertility in younger women.

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