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The more science progresses, the more life and society change. Medicine also changes with the times and the culture. This is also true for radiation emergency medicine, which includes dose-assessment leading to diagnosis, treatment, medical follow-up and prognosis of persons who have developed acute injury or illness due to radioactive contamination or radiation exposure. Before the report of X-rays by Roentgen, there was evidence that X-rays had been emitted from the electrically excited Crookes tube and that skin injury had been caused by the X-rays. Thus, the history of radiation and its exposure started before Roentgen. During the early stage of radiation use, people were simply exposed to radiation but were unaware of any danger. Radioactive materials were found soon after Roentgen’s report, and contamination with these materials occurred. Together with the development of science and technology, sophisticated radiation devices were produced, and the use and application of radiation became much enhanced. New radionuclides were found one after another, leading to identification of different qualities of radiation. Development of nuclear physics allowed people to artificially produce radionuclides and to construct a nuclear reactor. After World War II, nuclear power plants were constructed, and related facilities such as nuclear fuel processing, reprocessing and spent fuel storage facilities were built. If radiation accidents or events occur at such facilities, radiation exposure with thermal or chemical burns could occur. Together with the expansion of globalism in the world and division in the society, there are now increasing concerns regarding the malicious usage of radiation by radiological dispersal devices (RDDs) including a dirty bomb. Upon detonation of RDDs, blast and thermal injuries with radiation exposure could be caused. In the present society, the natures of exposure to radiation and contamination with radioactive materials have become much more complicated. Not even mentioning the atomic bomb, the detonation of RDDs also necessitates scenarios of medical responses to complicated injuries and the involvement of numbers of people. This article looks back at the history of radiation and addresses the medical responses to radiation injuries that change with the times.
The more science progresses, the more life and society change. Medicine also changes with the times and the culture. This is also true for radiation emergency medicine, which includes dose-assessment leading to diagnosis, treatment, medical follow-up and prognosis of persons who have developed acute injury or illness due to radioactive contamination or radiation exposure. Before the report of X-rays by Roentgen, there was evidence that X-rays had been emitted from the electrically excited Crookes tube and that skin injury had been caused by the X-rays. Thus, the history of radiation and its exposure started before Roentgen. During the early stage of radiation use, people were simply exposed to radiation but were unaware of any danger. Radioactive materials were found soon after Roentgen’s report, and contamination with these materials occurred. Together with the development of science and technology, sophisticated radiation devices were produced, and the use and application of radiation became much enhanced. New radionuclides were found one after another, leading to identification of different qualities of radiation. Development of nuclear physics allowed people to artificially produce radionuclides and to construct a nuclear reactor. After World War II, nuclear power plants were constructed, and related facilities such as nuclear fuel processing, reprocessing and spent fuel storage facilities were built. If radiation accidents or events occur at such facilities, radiation exposure with thermal or chemical burns could occur. Together with the expansion of globalism in the world and division in the society, there are now increasing concerns regarding the malicious usage of radiation by radiological dispersal devices (RDDs) including a dirty bomb. Upon detonation of RDDs, blast and thermal injuries with radiation exposure could be caused. In the present society, the natures of exposure to radiation and contamination with radioactive materials have become much more complicated. Not even mentioning the atomic bomb, the detonation of RDDs also necessitates scenarios of medical responses to complicated injuries and the involvement of numbers of people. This article looks back at the history of radiation and addresses the medical responses to radiation injuries that change with the times.
The risks of severe ionizing radiation exposure are increasing due to the involvement of nuclear powers in combat operations, the increasing use of nuclear power, and the existence of terrorist threats. Exposure to a whole-body radiation dose above about 0.7 Gy results in H-ARS (hematopoietic acute radiation syndrome), which is characterized by damage to the hematopoietic system; higher doses result in further damage to the gastrointestinal and nervous systems. Only a few medical countermeasures for ARS are currently available and approved for use, although others are in development. Cell therapies (cells or products produced by cells) are complex therapeutics that show promise for the treatment of radiation injury and have been shown to reduce mortality and morbidity in animal models. Since clinical trials for ARS cannot be ethically conducted, animal testing is extremely important. Here, we describe cell therapies that have been tested in animal models. Both cells and cell products appear to promote survival and lessen tissue damage after whole-body irradiation, although the mechanisms are not clear. Because radiation exposure often occurs in conjunction with other traumatic injuries, animal models of combined injury involving radiation and future countermeasure testing for these complex medical problems are also discussed.
Particle resuspension corresponds to the process by which discrete particles adhering on a surface are pulled off and carried away by a fluid flow. This is a typical example involving a web of phenomena pertaining to fluid mechanics, particle dynamics and interface chemistry whose cross-effects create an intricate topic. In this presentation, we bring insights into the rich complexity of the phenomena related to particle resuspension. This is illustrated on a few selected examples, which highlight both the challenges faced when measuring particle resuspension and the questions raised when building up models that reproduce some of the processes occurring at extremely different space and time scales. During this journey through multiscale approaches for complex physical phenomena, insights on ongoing ideas and developments are provided to stimulate interest into this everyday but challenging issue in physics.
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