Review of Phytochemical and Medical Applications of Annona Muricata Fruits

Abstract

Cancer disease is increasing annually worldwide, creating some concerns regarding the efficacy of the present treatment options. This has caused patients to seek alternatives to complement the chemotherapy, radiotherapy, and surgery. Annona muricata (family annonaceae) is a medicinal plant and is a fruit tree with a long history of traditional use. Annona muricata contains significant anticancer agents which called acetogenins play an important role in several cancer types. Annona Muricate has specific bioactive constituents responsible for the major anticancer, antioxidant, antimicrobial, anti-inflammatory and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alkaloids, flavonoids, sterols, and others. This review focuses on the phytochemistry, biological activities, medicinal are used as anti-cancer and antibiotic, also focuses on the mechanisms of action for the fruit extracts and acetogenins, in order to stimulate additional studies on the fruit pulp used for human consumption.

Antitumor Potential of Annona muricata Linn. An Edible and Medicinal Plant in Mexico: In Vitro, In Vivo, and Toxicological Studies

“…The medicinal uses of the Annonaceae family were reported long ago; it is widely distributed in tropical and subtropical regions. A. muricata (Figure 1) has become one of the best known, commercialized, and widely studied species in recent decades due to its therapeutic potential and traditional use [8][9][10]. It is known as "graviola", "soursop", and "guanabana" in Mexico is called "zapote de Viejas," "catucho," and "cabeza de negro [11]."…”

Pengaruh Perbedaan Jenis Pelarut Terhadap Kadar Flavonoid Total Ekstrak Daun Sirsak (Annona muricata L.)

“…Flavonoid termasuk senyawa fenolik yang kaya akan gugus hidroksil dan diketahui memiliki aktivitas yang besar sebagai antioksidan yaitu dengan cara menangkal radikal bebas yang berperan pada timbulnya penyakit degeneratif melalui mekanisme perusakan sistem imunitas tubuh, oksidasi lipid dan protein (Rao et al, 2020), sebagai antimikroba dan antiinflamasi (Errayes et al, 2020).…”

Phytochemical analysis of Annona atemoya seed extract by HPLC and their ability to inhibit the growth of Agrobacterium tumefaciens

“…In both in vivo and in vitro experiments, a number of phytochemical components fruit's were isolated from A. atemoya which was evaluated for their biological potential. The most extensively researched parts of A. atemoya which have chemical and pharmacological qualities are its leaves, fruits, and seeds (Errayes et al 2020;Nolasco-González et al 2022). Annona atemoya (Atemoya) is a tropical plant famous for its fruits which contain large amounts of phenolic compounds, flavonoids, and alkaloids.…”