Review of porphyrin-based photodynamic therapy materials

Abstract

Review of porphyrin-based photodynamic therapy materials

Supercritical CO2 Synthesis of Porous Metalloporphyrin Frameworks: Application in Photodynamic Therapy

“…The PDT procedure is based on the local application of a photosensitizer in the affected area that, by light radiation of a certain wavelength, induces the formation of reactive oxygen species (ROS) able to destroy the harmful cells through either necrosis or apoptosis . In this technique, the use of net porphyrins is often limited by their low biostability in aqueous media, self-aggregation, and nonselective tumor targeting . Some of these drawbacks can be significantly attenuated by building porous structures in which the porphyrins are the organic linkers located between metal-containing species, thus obtaining porphyrin-based MOFs.…”

“… 9 In this technique, the use of net porphyrins is often limited by their low biostability in aqueous media, self-aggregation, and nonselective tumor targeting. 10 Some of these drawbacks can be significantly attenuated by building porous structures in which the porphyrins are the organic linkers located between metal-containing species, thus obtaining porphyrin-based MOFs. From them, the so-called fourth generation of photosensitizers is built, 11 where the porphyrin moieties are somehow isolated and their aggregation is hindered.…”