Review of primary unknown cancer: cases referred to the National Cancer Center Hospital East

Matsubara, Nobuaki; Mukai, Hirofumi; Nagai, Shunji; Itoh, Kuniaki

doi:10.1007/s10147-010-0112-3

Cited by 11 publications

(13 citation statements)

References 17 publications

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“…The period from onset of symptoms to CUP patients' visit to cancer specialists is usually long, during which patients' general condition may deteriorate (6). The fact that primary origin of cancer is unidentified is hard to accept for patients with CUP, who likely feel distressed (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…Extensive examinations can provide useful results only for a minority of patients (8). The medical staff as well as patients with CUP still often feel anxious and uncertain of the diagnosis and treatment of CUP through the clinical course (6).…”

Section: Introductionmentioning

confidence: 99%

“…Health Service (NHS) have been recently published (4,5), but medical staff still do not have enough knowledge and experience of this disorder (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Psychological burden on patients with cancer of unknown primary: from onset of symptoms to initial treatment

Ishida

Ando

Komatsu

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: Supportive care is a critical issue especially for patients with cancer of unknown primary since they often face serious situations, continuing to seek for relevant diagnosis and treatment with the primary sites unknown. However, there are only few research reports on this subject. The aim of this study was to clarify the experience on patients with cancer of unknown primary until they have their initial treatment and to obtain suggestions of supportive care for them. Methods: A qualitative study using semi-structured interviews regarding the experience on patients with cancer of unknown primary was conducted. Results: Data of the experience of the nine patients with cancer of unknown primary until their initial treatment were collected by semi-structured interviews. Patients' speech at interviews recorded in verbatim reports was assigned with 545 codes, 102 subcategories and 38 categories. Experience of the patients with cancer of unknown primary was categorized into five phases: Phase 1: period of making self-judgment on symptoms; Phase 2: period of suspecting serious disease, and seeking for appropriate medical treatment; Phase 3: period of searching for cause of disease while having painful symptoms and anxiety; Phase 4: period of having fear for death, frustration with unknown cause and denial of unknown state; Phase 5: period of struggling but being determined to face disease. Conclusions: Experience of patients with cancer of unknown primary from onset of symptoms to their initial treatment was categorized into five phases, mainly manifesting their psychological burden. These findings will warrant for the future study of supportive care for patients with cancer of unknown primary.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychological burden on patients with cancer of unknown primary: from onset of symptoms to initial treatment

Ishida

Ando

Komatsu

et al. 2016

Japanese Journal of Clinical Oncology

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“…There are several possible explanations as to why these tumors were found particularly after CUP. First, the common primary sites for CUP are the lung, pancreas, ovary, kidney, colorectum, and liver (Briasoulis and Pavlidis, 1997;Gallagher and Reznek, 2008;Matsubara et al, 2010), thereby resulting in more diagnostic activities in these anatomic sites to find tumors. Second, CT scans of the thorax, abdomen, or pelvis are recommended for all CUP patients (Pavlidis et al, 2010), yielding a relatively high detection rate of tumors in these sites.…”

Section: Discussionmentioning

confidence: 99%

Second primary cancers after cancer of unknown primary in Sweden and Germany

Líu¹,

Hemminki²,

Sundquist

et al. 2013

European Journal of Cancer Prevention

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In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnostic approaches applied after any other cancer. The number of CUP patients identified in the nationwide Swedish database and nine German cancer registries was 24 641 from 1997 through 2006, and rate ratios (RRs) for SPCs were recorded in two follow-up periods. The detection rate of SPCs immediately after any other cancer was about two times higher in Germany than in Sweden, but the rate immediately after CUP was almost the same for the two datasets. In the joint analyses after CUP, the RRs of liver, lung, breast, and kidney cancers were higher than after any other cancer, whereas the RRs of prostate, urinary bladder, and connective tissue cancers as well as non-Hodgkin's lymphoma were not significantly different; the RR of cancers of upper aerodigestive tract was lower after CUP than after any other cancer. The joint data indicate that the work-up is efficient in detecting tumors in the thoracoabdominal organs that are screened by computed tomography. For some other organ sites, the more sign/symptom-directed diagnostic approaches may be equally efficient. However, none of the applied techniques could detect all tumors immediately after the first diagnosis.

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“…CUP accounts for approximately 3 to 5% of all malignancies, and is thus not particularly rare [1,2]. However, CUPs are a heterogeneous group of malignant neoplasms with different biological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Poorly differentiated mesenteric carcinoma of unknown primary site detected by abscess formation: case report

et al. 2014

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BackgroundCarcinoma of unknown primary site (CUP) is said to account for approximately 3 to 5% of all carcinomas. However, an isolated lesion in the abdominal cavity is rare, and there are no reports describing associated abscess formation.Case presentationA 76-year-old woman had consulted a previous physician complaining of fever and right lower quadrant abdominal pain. Enhanced computed tomography (CT) showed an abscess formation around the cecum. She was treated conservatively with antibiotics, but the symptoms relapsed and she consulted our hospital. Enhanced CT showed a persistent abscess, a tumorous lesion in the mesentery and right hydronephrosis. Because malignancy could not be ruled out, surgical treatment was selected. At laparotomy, encapsulated abscesses were found on the mesenteric side and outside of the ileocecal region. When we raised the ileocecal region, a tumor was found to be fixed to the right ureter, and there was leakage of white, solid tumor content. This tumor content was submitted to intraoperative frozen section diagnosis which revealed a carcinoma. Ileocecal resection with D3 lymph node dissection and retroperitoneal tumor resection was thus performed. There were no abnormal findings in the uterus and adnexa, nor any evidence of peritoneal dissemination. We regarded this case as an incomplete resection and chemotherapy with paclitaxel and carboplatin was administered. The patient has remained alive and disease-free for almost one year since the primary operation.ConclusionWe described a case with mesenteric CUP discovered during surgery for an intra-abdominal abscess. It is necessary to pay attention to treatment-resistant intraperitoneal abscesses as they may accompany a tumor.

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Review of primary unknown cancer: cases referred to the National Cancer Center Hospital East

Abstract: In about half of the patients with preliminary diagnosed PUC, the primary origin could be identified, or it was possible to distinguish subsets with favorable prognosis.

Cited by 11 publications

References 17 publications

Psychological burden on patients with cancer of unknown primary: from onset of symptoms to initial treatment

Psychological burden on patients with cancer of unknown primary: from onset of symptoms to initial treatment

Second primary cancers after cancer of unknown primary in Sweden and Germany

Poorly differentiated mesenteric carcinoma of unknown primary site detected by abscess formation: case report

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