Review of probiotic use in otolaryngology

Bourdillon, Alexandra T; Edwards, Heather

doi:10.1016/j.amjoto.2020.102883

Cited by 12 publications

(11 citation statements)

References 100 publications

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“…Probiotics and prebiotics can be used for the prevention and even the treatment of specific diseases, as they can regulate systemic and local immune system activity [16]. Some probiotics even propagate wound healing and minimize the risk of perioperative infection, which has become an increasingly relevant complication of head and neck procedures [19]. Probiotics and prebiotics have been used as a therapeutic tool for various GI disorders due to their anti-inflammatory and antimicrobial effects.…”

Section: Clinical Uses Of Probiotics and Prebioticsmentioning

confidence: 99%

“…Probiotics and prebiotics have been used as a therapeutic tool for various GI disorders due to their anti-inflammatory and antimicrobial effects. More recently, studies have shown the efficacy of probiotics in otolaryngological conditions such as rhinosinusitis, obstructive sleep apnea, and head and neck cancer; however, there is still a paucity of the literature evaluating their utility in otological disorders [19,53,54].…”

Section: Clinical Uses Of Probiotics and Prebioticsmentioning

confidence: 99%

“…Studies have shown that chronic inflammation is at the root of various auditory disorders, including sensorineural hearing loss (SNHL), otitis media, and tinnitus [16,18]. Recent studies have demonstrated how maintaining a healthy gut microbiome via an increased intake of monounsaturated as well as omega-3 polyunsaturated fatty acids and a decreased intake of saturated fat can help to suppress host inflammatory pathways, including those present in the auditory system [19,20]. Furthermore, these diets facilitate the maintenance of homeostasis by providing protection against oxidative stress, inflammation, platelet aggregation, and modification of hormones and growth factors contributing to disease pathogenesis [16].…”

Section: Introductionmentioning

confidence: 99%

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Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders

Godur,

Denton,

Eshraghi

et al. 2023

Audiology Research

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The gut microbiome has been shown to play a pivotal role in health and disease. Recently, there has been increased interest within the auditory community to explore the role of the gut microbiome in the auditory system and its implications for hearing disorders such as sensorineural hearing loss (SNHL), otitis media, and tinnitus. Studies have suggested that modulating the gut microbiome using probiotics as well as with diets high in monounsaturated and omega-3 fatty acids is associated with a reduction in inflammation prevalence in auditory disorders. This review aims to evaluate the current literature on modulation of the gut microbiome and its effects on otological conditions. The probiotic conversion of nondigestible carbohydrates into short-chain fatty acids has been shown to provide benefits for improving hearing by maintaining an adequate vascular supply. For acute and secretory otitis media, studies have shown that a combination therapy of probiotics with a decreased dose of antibiotics yields better clinical outcomes than aggressive antibiotic treatment alone. Gut microbiome modulation also alters neurotransmitter levels and reduces neuroinflammation, which may provide benefits for tinnitus by preventing increased neuronal activity. Further studies are warranted to evaluate the efficacy of probiotics, natural health products, and micronutrients on auditory disorders, paving the way to develop novel interventions.

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Section: Clinical Uses Of Probiotics and Prebioticsmentioning

confidence: 99%

Section: Clinical Uses Of Probiotics and Prebioticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders

Godur,

Denton,

Eshraghi

et al. 2023

Audiology Research

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“…Probiotic supplementation is another strategy based on natural preparations worth mentioning in RTI prophylaxis. The beneficial effect of probiotic strains on the duration and severity of RTIs, including Rhinovirus , Influenza , RSV, and S. pneumoniae infections, has been long studied and established [ 181 , 182 , 183 ]. It is owed to several mechanisms, among which the most important are (1) immunomodulation—probiotic bacteria comprising immunostimulatory constituents such as peptidoglycan, lipoteichoic acid, Toll-like receptor ligands, and muramyl dipeptide; their use leads to an increase in the level of type I interferons, the number and activity of natural killer (NK) cells, T cells, and IgA-expressing B cells in the colon and lymph nodes, and the level of specific antibodies in the lungs [ 184 , 185 ]; (2) production of antimicrobial substances (lactic acid, hydrogen peroxide, and bacteriocins) [ 185 ]; (3) competitive adhesion of probiotic bacteria on the sites of potential colonization of pathogenic bacteria [ 186 ], and (4) interaction with receptors, binding domains, and suppression of toxin-mediated responses [ 186 ].…”

Section: Prevention and Prophylaxis Of Rti’smentioning

confidence: 99%

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

et al. 2022

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In this time of COVID-19 pandemic, the strategies for prevention of the infection are a primary concern. Looking more globally on the subject and acknowledging the high degree of misuse of protective face masks from the population, we focused this review on alternative pharmaceutical developments eligible for self-defense against respiratory infections. In particular, the attention herein is directed to the nasal and oromucosal formulations intended to boost the local immunity, neutralize or mechanically “trap” the pathogens at the site of entry (nose or mouth). The current work presents a critical review of the contemporary methods of immune- and chemoprophylaxis and their suitability and applicability in topical mucosal dosage forms for SARS-CoV-2 prophylaxis.

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“…As a result, new strategies in managing AR patients have been advanced to restore the microbial population's imbalanced composition in a qualitative and quantitative sense [15,16]. In addition, probiotics have been assigned a prominent role as potential contributors to eubiosis [17].…”

Section: Introductionmentioning

confidence: 99%

Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?

Ciprandi

Tosca

2022

Allergies

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Allergic rhinitis (AR) is a widespread medical condition affecting up to 40% of the general population. Type 2 inflammation determines typical nasal symptoms. In addition, gut and respiratory dysbiosis are present in AR patients. Probiotics have several beneficial effects on immunity, inflammatory pathways, and anti-infective properties. Namely, probiotic supplementation could restore immune response, promote eubiosis, and switch off inflammation. Thus, probiotics have also been investigated in AR. In addition, there is accumulating evidence that some specific strains of probiotics may improve AR. Five meta-analyses on probiotics in AR management were consistently published in the first half of 2022. The conclusions, although not definitive, argue for the possible use of probiotics as part of an add-on strategy in managing patients with allergic rhinitis.

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Review of probiotic use in otolaryngology

Cited by 12 publications

References 100 publications

Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders

Modulation of Gut Microbiome as a Therapeutic Modality for Auditory Disorders

Advances in the Prophylaxis of Respiratory Infections by the Nasal and the Oromucosal Route: Relevance to the Fight with the SARS-CoV-2 Pandemic

Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them?

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