Review of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis

Zhou, Jiemin; Huang, Zi‐Ao; Kumar, Ujendra; Chen, David D. Y.

doi:10.1016/j.aca.2017.09.021

Cited by 105 publications

(59 citation statements)

References 109 publications

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“…Pentane and ethane, as well as malondialdehyde, are commonly found in A c c e p t e d M a n u s c r i p t 7 human breath and have been shown to correlate with oxidative stress in different clinical settings 49 . Importantly, products of lipid peroxidation are among the most common breath biomarkers of lung cancer 46 . The levels of decane [50][51][52][53][54][55][56][57] , heptanal 50,52,[58][59][60] , octane 51,54,58,61 , and undecane 50,52,57,58,62 have consistently been found to be increased in the breath of patients with lung cancer, compared to controls.…”

Section: Lipid Peroxidationmentioning

confidence: 99%

The potential of breath analysis to improve outcome for patients with lung cancer

et al. 2019

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Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such requirements. Numerous studies have shown that VOC profiles are different in the breath of patients with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This review provides a scientific and clinical assessment of the potential value of a breath test in lung cancer. It discusses the current understanding of metabolic pathways that contribute to exhaled VOC production in lung cancer and reviews the research conducted to date. Finally, we highlight important areas for future research and discuss how a breath test could be incorporated into various clinical pathways.

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Section: Lipid Peroxidationmentioning

confidence: 99%

The potential of breath analysis to improve outcome for patients with lung cancer

et al. 2019

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“…Volatolomics, the study of volatile organic compounds (VOCs) produced by living systems, is an emerging field of research that offers promise for exploring biological processes in real‐time . Within this framework, analysis of VOCs in exhaled breath samples has been investigated for cancer diagnosis and patient stratification for personalised anticancer therapy . However, high inter‐individual variability as well as inter‐laboratory disparities for sample preparation and analysis represent major hurdles that still limit the use of volatolomics in clinics.…”

Section: Figurementioning

confidence: 99%

Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers

et al. 2019

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The development of efficient protocols for cancer diagnosis remains highly challenging. An emerging approach relies on the detection in exhaled breath of volatile organic compounds (VOC) produced by tumours.I nt his context, described here is anovel strategy in whichaVOC-based probe is converted selectively in malignant tissues,b yatumourassociated enzyme,for releasing the corresponding VOC. The latter is then detected in the exhaled breath as atumour marker for cancer diagnosis.T his approach allows the detection of several different tumours in mice,t he monitoring of tumour growth and tumour response to chemotherapy. Thus,t he concept of "induced volatolomics" provides an ew way to explore biological processes using VOC-based probes that could be adapted to many biomedical applications.

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“…The extraction material can be applied as a thin film (thin‐film microextraction), so the surface for the extraction is larger and consequently the sample volumes can be increased . This method is very popular for non‐invasive direct analysis of breath, skin or saliva . The possibility of direct connection with MS is also a great advantage, specifically in direct analysis in real time (DART‐MS/MS), where the extraction membrane is placed in the instrument without any previous desorption step .…”

Section: Sorbent‐based Microextractionmentioning

confidence: 99%

“…The extraction material can be applied as a thin film (thin-film microextraction), so the surface for the extraction is larger and consequently the sample volumes can be increased [89,90]. This method is very popular for non-invasive direct analysis of breath, skin or saliva [91,92].…”

Section: Sorbent-based Microextractionmentioning

confidence: 99%

Critical evaluation of microextraction pretreatment techniques – Part 1: Single drop and sorbent‐based techniques

Havlíková

Čabala

Pacáková

et al. 2018

J of Separation Science

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Sample pretreatment techniques or preconcentration constitute a very important step before the analysis of environmental, clinical, pharmaceutical, and other complex samples. Thanks to extraction techniques it is possible to achieve higher method sensitivities and selectivities. Miniaturization microextraction methods make them more environmentally friendly and only small amounts of samples are required. In the past 30 years, a number of microextraction methods have been developed and used and are documented in thousands of articles. Many reviews have been written focusing on their use in specified professional fields or on the latest trends. Unfortunately, no uniform nomenclature has been introduced for these methods. Therefore, this review attempts to classify all the essential microextraction techniques and describes their advantages, disadvantages, and the latest innovations. The methods are divided into two main groups: single drop and sorbent‐based techniques according to the type of extraction phase.

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Review of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis

Cited by 105 publications

References 109 publications

The potential of breath analysis to improve outcome for patients with lung cancer

The potential of breath analysis to improve outcome for patients with lung cancer

Volatile Organic Compound Based Probe for Induced Volatolomics of Cancers

Critical evaluation of microextraction pretreatment techniques – Part 1: Single drop and sorbent‐based techniques

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