Concrete viaducts are an important part of the urban rail transit system but they produce considerable noise pollution in the communities nearby. The vibration generated at the wheel-rail interface is transmitted along the rail and also into the bridge so that noise is radiated from both the rail and the bridge. To facilitate noise predictions it is desirable to develop a model that takes into account the vibration generation and transmission in the traintrack-bridge system. The vibration and the associated noise of the track-bridge system are computed with a unified vibro-acoustic model using a wavenumber domain finite element and boundary element method. An important aspect is shown to be the frequency-dependent stiffness of a typical rail fastener utilized on bridges due to resonance of the baseplate between two rubber pads. In this study a multi-layer fastener model is proposed to allow for this effect. The proposed procedure is applied to a viaduct with a U-shaped section and compared with field measurements during train pass-bys. The elastic modulus and damping of the rubber pads and equivalent loss factor of the rail are chosen by fitting the calculated track decay rates to those estimated from measured rail accelerations under train passages. The wheel-rail combined roughness is also derived from the measured rail vibration. A comparison is then made between the simulated and measured bridge vibration to verify the proposed method as well as the parameters used in the track-bridge system. The predicted noise levels are also compared with the measured results. The effects of the fastener model, fastener stiffness, bridge damping and interference between multiple wheels are then discussed. It is found that the bridge noise has a non-negligible effect on the total A-weighted noise levels in the region beneath the bridge and up to 30 m away from the track.