Review of renal biopsy database: A single centre South Indian study

Devadass, Clement Wilfred; Mysorekar, Vijaya V; Ms, Gireesh; Mahesh, E; Kc, Gurudev; Radhika, K

doi:10.5958/2319-5886.2014.00032.0

Cited by 3 publications

(1 citation statement)

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“…If they were not classifiable as PGD or SGD, they have been included separately as CGS. Finally, we compare the data of this study with that of our previous data (16) and the data from neighbouring regions of our country (16)(17)(18) as well as other registries across the globe (19,20).…”

Section: Resultsmentioning

confidence: 90%

Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

et al. 2020

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Introduction: Biopsy registries are important in studying the frequency of kidney diseases, their trends over time and allow comparison of data from different geographical regions. Objectives: We report the spectrum of biopsy-proven glomerular and tubular diseases in a single centre in Eastern India. Patients and Methods: Medical records of 1293 patients with biopsy-proven glomerular diseases (GDs) and tubular diseases over a period of three years (March 2013 to March 2016) were retrospectively analysed. All biopsy specimens were examined by the same pathologist with light and immunofluorescence microscopy. Electron microscopic (EM) analysis was performed only in selected cases. Histologic spectrum of various GDs was studied along with its correlation with the clinical and laboratory parameters. Results: The clinical diagnosis was nephrotic syndrome (NS) in 820 (63.41%), rapidly progressive glomerulonephritis in 194 (15.2%), asymptomatic urinary abnormalities (AUA) in 108 (8%), acute kidney injury (AKI)/acute nephritic syndrome in 118 (9.3%), and macroscopic hematuria (MH) in 3 (0.43%) patients. Male: Female ratio was 0.95. Around 22.42% were < 18 years, 72.2% were between 18to 59 years, and 5.3% were ≥ 60 years of age. The most common GD overall as well as primary glomerular disease (PGD) was minimal change disease (MCD) (21.6 and 83.44%). Secondary GD was present in 20.87%; most common being lupus nephritis (84.58%). Among the NS, the most common GD was MCD (33.17%), followed by FSGS (17.56%), membranous nephropathy (MN) (13.90%), lupus nephritis (LN) (9.39%), IgA-nephropathy (0.49%), and MPGN (7.32%). Thrombotic microangiopathy (TMA) constituted 24.6% of AKI presentation particularly common in pregnancy. Diffuse proliferative glomerulonephritis (DPGN) with severe renal dysfunction was present in 14% of elderly patients. Conclusion: The spectrum of GD varies according to the area of study and changes over time. Some entities which have not been reported earlier from this region that are uncommon but are significant were pregnancy associated TMA, C3 glomerulopathy (C3G) and DPGN in adults.

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Section: Resultsmentioning

confidence: 90%

Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

et al. 2020

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Spectrum of Biopsy Proven Renal Diseases (BPRD): A Single Center Experience

GR¹,

Indu²,

Seethalekshmy³

et al. 2016

jmscr

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Renal biopsy reports in nephritic syndrome: Update

Taheri¹

2022

WJN

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BACKGROUND Nephritic syndrome (NiS) is a major indicator of serious renal diseases necessitating kidney biopsies for histopathological evaluations, but due to the lack of comprehensive reviews in the literature, the current understanding of the syndrome and its significance is limited. AIM To collect all the evidence retrievable from the literature on the diagnoses made on the renal biopsies performed for NiS as the indication to the procedure. METHODS A literature search was conducted to find studies reporting final diagnoses on renal biopsies in NiS patients. Data were pooled and analyzed with stratifications on age and regions. Meta-analyzes were performed using Stata v.9. RESULTS Overall, 26414 NiS patients from the total number of 96738 kidney biopsy diagnoses reported by 47 studies from 23 countries from all continents (except sub-Saharan Africa) were found and analyzed. NiS was the indication for renal biopsy in 21% of the patient populations across the reviewed studies. Immunoglobulin A (IgA) nephropathy was the single most frequent diagnosis in these patients (approximately 38%) followed by lupus nephritis (approximately 8%) and Henoch Schönlein purpura (approximately 7%). IgA nephropathy was the most frequent diagnosis reported for the NiS patients from the East Asia, comprising half of all the cases, and least prevalent in South Asia. Considering the age subgroups, adult ( vs pediatric or elderly) patients were by far the most likely age group to be diagnosed with the IgA nephropathy. A myriad of such regional and age disparities have been found and reported. CONCLUSION As the indication for renal biopsy, NiS represents a very distinctive epidemiology of final renal disease diagnoses compared to the other major syndromes.

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Review of renal biopsy database: A single centre South Indian study

Cited by 3 publications

References 0 publications

Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

Spectrum of Biopsy Proven Renal Diseases (BPRD): A Single Center Experience

Renal biopsy reports in nephritic syndrome: Update

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