Review of serotonergic agents and perseverative behavior in patients with developmental disabilities

Mood and Anxiety Symptoms in An Adolescent with Pervasive Developmental Disorder Not Otherwise Specified and Moderate Mental Retardation

“…In a randomized controlled trial of fluvoxamine in 30 adults with PDD, McDougle et al (1996) reported that the majority of patients experienced reduced perseverative behaviors and aggression (McDougle et al 1996). Among the SSRIs there appears to be the most data on fluoxetine in the MR/PDD population, reviewed by Aman et al (1999). Of 15 case reports and 4 prospective open studies, depressive symptoms, irritability and self-injuries were reported to improve in the majority of patients (Aman et al 1999).…”

“…Among the SSRIs there appears to be the most data on fluoxetine in the MR/PDD population, reviewed by Aman et al (1999). Of 15 case reports and 4 prospective open studies, depressive symptoms, irritability and self-injuries were reported to improve in the majority of patients (Aman et al 1999).…”

Pain and autism

“…Une déplétion de sérotonine centrale aurait comme conséquence une hyperalgésie dans l'autisme plutôt qu'une diminution de la douleur. Dans le même ordre d'idée, les inhibiteurs sélectifs de la recapture de la sérotonine (ISRS) sont parfois utilisés dans le traitement de l'autisme ; ils amélioreraient les comportements compulsifs, les stéréotypies et les comportements d'automutilation [1]. Paradoxalement, les ISRS ont été étudiés pour le traitement de certains syndromes de douleur chronique [50].…”

A Review of Empirical Evidence of Somatic Treatment Options for the MI/DD Population

“…Given the high rate of SSRI use in this population, the complete dearth of well conducted studies for this class of medications is surprising. Aman et al [19] reviewed numerous open studies on SSRI's and concluded that SSRI's are useful in anxiety and depression in MR/DD patients.…”