“…They have made great efforts to understand the penetration of drugs through the skin. The permeation data, however, were frequently analyzed on simplistic assumptions such as a single layer skin, a constant diffusivity, a steady-state condition, a simplified boundary condition, a compartment model of skin, etc>l-3, 6,8,9,[12][13][14]18,21,23,37,43,44) A mQre^^^_ proach is needed, at this stage of transdermal drug delivery studies, to elucidate the mechanism of percutaneous absorption.…”