Review of stationary phases for microelectromechanical systems in gas chromatography: feasibility and separations

Azzouz, Imadeddine; Vial, Jérôme; Thiébaut, Didier; Haudebourg, R.; Danaie, K.; Sassiat, Patrick; Brévière, Jérôme

doi:10.1007/s00216-013-7168-7

Cited by 37 publications

(10 citation statements)

References 74 publications

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“…Different approaches based on MEMS technology have been developed and adopted for sample introduction [90,91] and micro-detection (e.g., flame ionization, electron capture, thermal conductivity, and photoionization detectors, and ion mobility spectrometers) [90]. However, in the EO field, most studies in the literature concerning μGC based on MEMS are focused on MEMS-based columns [90][91][92][93], probably because the separation step is manda-tory during their GC analysis. In this respect, in 2016, Cagliero et al [94] developed highly efficient MEMSbased columns (N/m above 8000) for the analysis of the plant volatiles, in particular for EOs.…”

Section: Instrument Miniaturizationmentioning

confidence: 99%

Gas chromatography of essential oil: State‐of‐the‐art, recent advances, and perspectives

Cagliero

Bicchi

Marengo

et al. 2022

J of Separation Science

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This review is an overview of the recent advances of gas chromatography in essential oil analysis; in particular, it focuses on both the new stationary phases and the advanced analytical methods and instrumentations. A paragraph is dedicated to ionic liquids as gas chromatography stationary phases, showing that, thanks to their peculiar selectivity, they can offer a complementary contribution to conventional stationary phases for the analysis of complex essential oils and the separation of critical pairs of components. Strategies to speed-up the analysis time, thus answering to the ever increasing request for routine essential oils quality control, are also discussed. Last but not least, a paragraph is dedicated to recent developments in column miniaturization in particular that based on microelectromechanical-system technology in a perspective of developing micro-gas chromatographic systems to optimize the energy consumption as well as the instrumentation dimensions. A number of applications in the essential oil field is also included.

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Section: Instrument Miniaturizationmentioning

confidence: 99%

Gas chromatography of essential oil: State‐of‐the‐art, recent advances, and perspectives

Cagliero

Bicchi

Marengo

et al. 2022

J of Separation Science

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“…Micro-gas chromatography (μGC) systems have shown immense growth in the last two decades [ 1 , 2 , 3 , 4 , 5 ]. It provides a less invasive option for gas analysis that can be monitored in real time and offer reliable quantitative data in essential sectors, including industry, healthcare, environment, and national security.…”

Section: Introductionmentioning

confidence: 99%

A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

et al. 2021

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The miniaturization of gas chromatography (GC) systems has made it possible to utilize the analytical technique in various on-site applications to rapidly analyze complex gas samples. Various types of miniaturized sensors have been developed for micro-gas chromatography (µGC). However, the integration of an appropriate detector in µGC systems still faces a significant challenge. We present a solution to the problem through integration of µGC with photonic crystal slab (PCS) sensors using transfer printing technology. This integration offers an opportunity to utilize the advantages of optical sensors, such as high sensitivity and rapid response time, and at the same time, compensate for the lack of detection specificity from which label-free optical sensors suffer. We transfer printed a 2D defect free PCS on a borofloat glass, bonded it to a silicon microfluidic gas cell or directly to a microfabricated GC column, and then coated it with a gas responsive polymer. Realtime spectral shift in Fano resonance of the PCS sensor was used to quantitatively detect analytes over a mass range of three orders. The integrated µGC–PCS system was used to demonstrate separation and detection of a complex mixture of 10 chemicals. Fast separation and detection (4 min) and a low detection limit (ng) was demonstrated.

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“…Since the late 1970s, various micro-gas chromatography (μ-GC) systems have been reported, and a subset of the necessary components of these systems has been lithographically microfabricated [19]. The resultant highly miniaturized systems based on micro-electromechanical systems (MEMS) have been used to fabricate GC columns [20,21,22,23]. However, most of the μ-GC systems reported to date have involved manual assembly of separately fabricated μ-GC components using commercially available off-chip fluidic interconnects.…”

Section: Introductionmentioning

confidence: 99%

Development of Open-Tubular-Type Micro Gas Chromatography Column with Bump Structures

Lee

Lim

2019

Sensors

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Gas chromatography (GC) is the chemical analysis technique most widely used to separate and identify gas components, and it has been extensively applied in various gas analysis fields such as non-invasive medical diagnoses, indoor air quality monitoring, and outdoor environmental monitoring. Micro-electro-mechanical systems (MEMS)-based GC columns are essential for miniaturizing an integrated gas analysis system (Micro GC system). This study reports an open-tubular-type micro GC (μ-GC) column with internal bump structures (bump structure μ-GC column) that substantially increase the interaction between the gas mixture and a stationary phase. The developed bump structure μ-GC column, which was fabricated on a 2 cm × 2 cm μ-GC chip and coated with a non-polar stationary phase, is 1.5 m-long, 150 μm-wide, and 400 μm-deep. It has an internal microfluidic channel in which the bumps, which are 150 μm diameter half-circles, are alternatingly disposed to face each other on the surface of the microchannel. The fabricated bump structure μ-GC column yielded a height-equivalent-to-a-theoretical-plate (HETP) of 0.009 cm (11,110 plates/m) at an optimal carrier gas velocity of 17 cm/s. The mechanically robust bump structure μ-GC column proposed in this study achieved higher separation efficiency than a commercially available GC column and a typical μ-GC column with internal post structures classified as a semi-packed-type column. The experimental results demonstrate that the developed bump structure μ-GC column can separate a gas mixture completely, with excellent separation resolution for formaldehyde, benzene, toluene, ethylbenzene, and xylene mixture, under programmed operating temperatures.

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Review of stationary phases for microelectromechanical systems in gas chromatography: feasibility and separations

Cited by 37 publications

References 74 publications

Gas chromatography of essential oil: State‐of‐the‐art, recent advances, and perspectives

Gas chromatography of essential oil: State‐of‐the‐art, recent advances, and perspectives

A Portable Micro-Gas Chromatography with Integrated Photonic Crystal Slab Sensors on Chip

Development of Open-Tubular-Type Micro Gas Chromatography Column with Bump Structures

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