2019
DOI: 10.1148/rg.2019180139
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Review of 18F-Fluciclovine PET for Detection of Recurrent Prostate Cancer

Abstract: Fluorine 18 (18 F) fluciclovine (anti-1-amino-3-18 F-fluorocyclobutane-1-carboxylic acid [FACBC]) is a radiolabeled amino acid analog that takes advantage of the amino acid transport upregulation in several types of cancer cells. FACBC is taken up to a greater extent in prostate cancer cells than in surrounding normal tissue, providing an opportunity for its use in cases of this common cancer. In 2016, the U.S. Food and Drug Administration found the accuracy of FACBC PET to be superior to that of other molecul… Show more

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Cited by 53 publications
(53 citation statements)
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“…The most intense physiologic tracer uptake is seen in the pancreas, which decreases within 15 min after injection to a level lower than that of the liver. The liver has second most intense physiologic activity and is the most critical organ for radiation [1,6]. Axumin PET image interpretation is predominantly visual or qualitative, rather than measurement of actual SUV.…”
Section: Discussionmentioning
confidence: 99%
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“…The most intense physiologic tracer uptake is seen in the pancreas, which decreases within 15 min after injection to a level lower than that of the liver. The liver has second most intense physiologic activity and is the most critical organ for radiation [1,6]. Axumin PET image interpretation is predominantly visual or qualitative, rather than measurement of actual SUV.…”
Section: Discussionmentioning
confidence: 99%
“…His PSA level was markedly elevated (6.1 ng/mL) from his baseline (< 0.1 ng/mL) indicating biochemical recurrence of the prostate cancer. Only < 5% of bone scans are positive for detecting bony metastasis at PSA level < 7 ng/ mL, as well as bone scans are more sensitive to detect sclerotic lesions [1]. Since our patient had radiologically occult disease with no significant abnormality on pelvic CT, our multidisciplinary team thought to proceed with Axumin PET/CT.…”
Section: Case Presentationmentioning
confidence: 92%
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