Based on the premise that university student dropout is a social problem in the university ecosystem of any country, technological leverage is a way that allows us to build technological proposals to solve a poorly met need in university education systems. Under this scenario, the study presents and analyzes eight predictive models to forecast university dropout, based on data mining methods and techniques, using WEKA for its implementation, with a dataset of 4365 academic records of students from the National University of Moquegua (UNAM), Peru. The objective is to determine which model presents the best performance indicators to forecast and prevent student dropout. The study aims to propose and compare the accuracy of eight predictive models with balanced classes, using the SMOTE method for the generation of synthetic data. The results allow us to confirm that the predictive model based on Random Forest is the one that presents the highest accuracy and robustness. This study is of great interest to the educational community as it allows for predicting the possible dropout of a student from a university career and being able to take corrective actions both at a global and individual level. The results obtained are highly interesting for the university in which the study has been carried out, obtaining results that generally outperform the results obtained in related works.