Review of the Applications of Biomedical Compositions Containing Hydroxyapatite and Collagen Modified by Bioactive Components

Abstract

Regenerative medicine is becoming a rapidly evolving technique in today’s biomedical progress scenario. Scientists around the world suggest the use of naturally synthesized biomaterials to repair and heal damaged cells. Hydroxyapatite (HAp) has the potential to replace drugs in biomedical engineering and regenerative drugs. HAp is easily biodegradable, biocompatible, and correlated with macromolecules, which facilitates their incorporation into inorganic materials. This review article provides extensive knowledge on HAp and collagen-containing compositions modified with drugs, bioactive components, metals, and selected nanoparticles. Such compositions consisting of HAp and collagen modified with various additives are used in a variety of biomedical applications such as bone tissue engineering, vascular transplantation, cartilage, and other implantable biomedical devices.

The potential of eggshell hydroxyapatite, collagen, and EGCG (HAp-Col-EGCG) scaffold as a pulp regeneration material

“…Microporosity can increase the biomaterial surface area and increased protein adsorption will further increase cell adhesion ( Herda and Puspitasari, 2018 ). It can support the transportation of nutrients and the bone regeneration process ( Sobczak-Kupiec et al, 2021 ).…”

Preparation, Characterization, and Biocompatibility Assessment of Polymer-Ceramic Composites Loaded with Salvia officinalis Extract

“…Thus, the polyvinylpyrrolidone/sodium alginate/hydroxyapatite composites enriched with polyphenols extracted from common sage, can be considered as composites to be used as a substrate to support the adhesion and proliferation of L929 mouse fibroblasts and should be further tested. Most organ and tissue damage resulting from congenital defects, trauma or chronic disease is treated surgically or pharmacologically [1,2]. As has been mentioned, great emphasis has been placed on intelligent, bioactive biomaterials which offer great potential for regenerative medicine, by, among other properties, stimulating surrounding tissues or delivering active components such as drugs or biomolecules [3].…”

Evaluation of the impact of pH of the reaction mixture, type of the stirring, and the reagents' concentration in the wet precipitation method on physicochemical properties of hydroxyapatite so as to enhance its biomedical application potential

“…1,2 It was also proved that HAp supports bone tissue regeneration and osteointegration, that is, formation of a direct connection between the living bone and the implant surface. 3 Thus, HAp is widely applied for preparation of polymer-ceramic composites designed for tissue engineering. [4][5][6] As the demand for HAp increases, so does the number of research performed on the synthesis methodology also increases.…”

“…Many investigations demonstrated its bioactivity, biocompatibility, osteoinductiveness, and osteoconductiveness 1,2 . It was also proved that HAp supports bone tissue regeneration and osteointegration, that is, formation of a direct connection between the living bone and the implant surface 3 . Thus, HAp is widely applied for preparation of polymer‐ceramic composites designed for tissue engineering 4–6 …”