Review of the fabrication techniques and applications of polymeric electrospun nanofibers for drug delivery systems

Ghafoor, Bakhtawar; Aleem, Amna; Ali, Murtaza Najabat; Mir, Mariam

doi:10.1016/j.jddst.2018.09.005

Cited by 88 publications

(38 citation statements)

References 58 publications

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“…Nanofiber mats have proven themselves as one of the most promising materials for controlled release, and possess several distinctive characteristics including large specific surface area by volume, high porosity as a result of randomly oriented non-woven fibers, light weight, and good mechanical properties [23][24][25][26]. Moreover, the interconnected pore structure allows the permeation of air and water, enabling thorough and effective release of active substances in contrast to conventional bulk film patches.…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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A controlled release system of Plai (Zingiber cassumunar Roxb.) oil based on electrospun poly(lactic) acid (PLA) nanofiber mat was successfully developed. The physicochemical properties of the nanofibers loaded with select amounts of oil (15%, 20%, and 30% wt) were characterized using various techniques, including a morphological study using scanning electron microscopy (SEM), structural determination using Fourier transform infrared spectrometry (FTIR) and x-ray diffraction (XRD), as well as thermal properties study using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The loading content and the entrapment efficiency of Plai oil within the fiber mats were evaluated and were found to be remarkably high, ensuring that PLA was an appropriate material for Plai oil loading. The ability of the nanofiber mats to release (E)-1-(3,4dimethoxyphenyl) butadiene (DMPBD) was also examined and the fiber mats showed controlled release characteristics. As the nanofiber mats have particularly high specific surface area with fully accessible and interconnected pore structures, a liquid medium with active ingredients will not be trapped in blind pores but can be fully released out of the fiber matrix. Furthermore, in vitro skin permeation of the active compound as well as a skin irritation were assessed using reconstructed human epidermis (EpiSkin TM ). It was found that DMPBD could efficiently penetrate through the skin model. Moreover, the nanofiber mats containing Plai oil also showed no skin irritation, indicating them as promising prototypes for medical applications.

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Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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“…Phase separation (e. g. thermally induced (TIPS) and vapor induced phase separation (VIPS)) is another method for producing porous fibers . Highly volatile solvents such as dichloromethane (DCM), acetone (ACE), tetrahydrofuran (THF), and chloroform, has the ability to generate porous fibers from various polymers such as polyvinylidene fluoride (PVDF), poly(vinyl chloride) (PVC), poly(methyl methacrylate) (PMMA), poly(L‐lactic acid) (PLLA), polystyrene (PS), poly(D,L‐lactide), poly(ϵ‐caprolactone), poly(vinyl acetate) (PVA), polycarbonate, polyvinyl butyral (PVB), ethylcellulose, polymethylsilsesquioxane, cellulose triacetate, and polyvinyl carbazole . Commonly, pores are created on the electrospun fibers’ surfaces due to TIPS.…”

Section: Secondary Surface Morphologies Of Electrospun Nanofibersmentioning

confidence: 99%

A Review on the Secondary Surface Morphology of Electrospun Nanofibers: Formation Mechanisms, Characterizations, and Applications

2020

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Engineering the secondary surface morphology of fibers (fibers without smooth surface and solid interior) has been attracting significant awareness in various areas and applications. Among different methods of forming nanofibers, electrospinning is the most widely adopted technique due to the ease of forming fibers with a broad range of properties and its unique advantages such as the flexibility to spin into a variety of shapes and sizes as well as adjustable porosity of electrospun structures. In this review paper, more emphasis is put on the secondary surface morphology. A comprehensive overview of the basic principles about the electrospinning process, types of electrospinning, materials, formation mechanisms, characterizations, and applications of electrospun fibers with the secondary surface morphology (e. g. the porous structure, grooved structure, wrinkled structure, rough structure, cactus structure, and hollow structure) are discussed in detail. Importantly, we believe our work can serve as guidelines for the preparations, characterizations, and applications of electrospun fibers with the secondary surface morphology.

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“…As is widely recognized, nitrogen doping of the active material is beneficial for the wettability and electrocatalytic activity of electrodes [6]. He et al [145] have synthesized PAN-based nitrogen-doped carbon fibers via electrospinning followed by fiber dispersion in the liquid phase (urea solution, with urea acting as an external nitrogen source) and carbonization at different temperatures (800-1000 • C).…”

Section: Secondary Redox Flow Batteriesmentioning

confidence: 99%

“…On the other hand, water wettability is known to be very beneficial to the diffusion and adsorption of ions in the solution to the fiber surface and results in improved surface utilization [212]. It is widely recognized that a high N-doping level of the active material is beneficial for the wettability of the electrode surface and pseudo-capacitance, as well [6,195]. Based on these concepts, Belaustegui et al [55] have demonstrated that ECNFs self-doped with very high nitrogen concentrations (around 20 wt%) are able to remove a relevant amount of NaCl (17.0 mg/g) from a salty solution with an initial concentration of 585 mg/L, and that the electrosorption capacity outstandingly increases (up to 27.6 mg/g) if the N-doped fibers are enriched with graphene ( Figure 27).…”

Section: Capacitive Deionization Of Watermentioning

confidence: 99%

“…The wide variety of intriguing nanomaterials with outstanding physical and chemical properties that can be produced by electrospinning (natural and synthetic polymers, ceramic oxides, carbon and composite carbon-based fibers, and fibrous flexible membranes with hierarchical porosity) find application in a plethora of both well-assessed and emerging applications, spanning from healthcare and biomedical engineering (e.g., wound dressing, biological sensing, drug and therapeutic agent delivery, tissue regeneration, and engineering) to environmental protection and remediation (e.g., chemical and gas sensing, photocatalytic abatement of pollutants, water treatment), from energy harvesting, generation, and storage (e.g., solar cells, hydrogen production and storage, supercapacitors, batteries, and fuel cells) to electronics (e.g., field-effect transistors, diodes, photodetectors, and electrochromic devices) [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrospun Nanomaterials for Energy Applications: Recent Advances

Santangelo

2019

Applied Sciences

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Electrospinning is a simple, versatile, cost-effective, and scalable technique for the growth of highly porous nanofibers. These nanostructures, featured by high aspect ratio, may exhibit a large variety of different sizes, morphologies, composition, and physicochemical properties. By proper post-spinning heat treatment(s), self-standing fibrous mats can also be produced. Large surface area and high porosity make electrospun nanomaterials (both fibers and three-dimensional fiber networks) particularly suitable to numerous energy-related applications. Relevant results and recent advances achieved by their use in rechargeable lithium- and sodium-ion batteries, redox flow batteries, metal-air batteries, supercapacitors, reactors for water desalination via capacitive deionization and for hydrogen production by water splitting, as well as nanogenerators for energy harvesting, and textiles for energy saving will be presented and the future prospects for the large-scale application of electrospun nanomaterials will be discussed.

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Review of the fabrication techniques and applications of polymeric electrospun nanofibers for drug delivery systems

Cited by 88 publications

References 58 publications

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

A Review on the Secondary Surface Morphology of Electrospun Nanofibers: Formation Mechanisms, Characterizations, and Applications

Electrospun Nanomaterials for Energy Applications: Recent Advances

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