Review of the genotoxicity of ozone

Victorin, Katarina

doi:10.1016/0165-1110(92)90045-b

Cited by 128 publications

(68 citation statements)

References 66 publications

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“…Ozone (O 3 ), the main pollutant for SWMMC is a highly reactive molecule that interacts with a wide variety of organic molecules including unsaturated fatty acids, proteins and nucleic acids to produce free radicals intermediates. O 3 initiates cascades of free radical reactions and causes extensive DNA damage as re ected by strand breaks, DNA interstrand crosslinks and protein crosslinks (36,48). Monkeys exposed to O 3 , 0.15 and 0.30 ppm for 6 or 90 days exhibit nasal lesions including acute rhinitis with an intraepithelial in ux of PMN, atenuation of cilia and individual ciliated cell degeneration and necrosis (26).…”

Section: Histopathologymentioning

confidence: 99%

Nasal Biopsies of Children Exposed to Air Pollutants

et al. 2001

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Southwest Metropolitan Mexico City (SWMMC) atmosphere is a complex mixture of air pollutants, including ozone, particulate matter, and aldehydes. Children in SWMMC are exposed chronically and sequentially to numerous toxicants, and they exhibit signi cant nasal damage. The objective of this study was to assess p53 accumulation by immunohistochemistr y in nasal biopsies of SWMMC children. We evaluated 111 biopsies from 107 children (83 exposed SWMMC children and 24 control children residents in a pollutant-compliant Caribbean island). Complete clinical histories and physical examinations, including an ear-nose-throat (ENT) exam were done. There was a signi cant statistical difference in the upper and lower respiratory symptomatolog y and ENT ndings between control and exposed children ( p < 0.001). Control children gave no respiratory symptomatolog y in the 3 months prior to the study; their biopsies exhibited normal ciliated respiratory epithelium and were p53-negative . SWMMC children complained of epistaxis, nasal obstruction, and crusting. Irregular areas of whitish-gray recessed mucosa over the inferior and middle turbinates were seen in 25% of SWMMC children, and their nasal biopsies displayed basal cell hyperplasia, decreased numbers of ciliated and goblet cells, neutrophilic epithelial in ltrates, squamous metaplasia, and mild dysplasia. Four of 21 SWMMC children with grossly abnormal mucosal changes exhibited strong transmural nuclear p53 staining in their nasal biopsies (p 0.005, odds ratio 26). In the context of lifetime exposures to toxic and potentially carcinogenic air pollutants, p53 nasal induction in children could potentially represent. a) a checkpoin t response to toxic exposures, setting up a selective condition for p53 mutation, or b) a p53 mutation has already occurred as a result of such selection. Because the biological signi cance of p53 nuclear accumulation in the nasal biopsies of these children is not clear at this point, we strongly suggest that children with macroscopic nasal mucosal abnormalities should be closely monitored by the ENT physician. Parents should be advised to decrease the children's number of outdoor exposure hours and encourage a balanced diet with an important component of fresh fruits and vegetables.

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Section: Histopathologymentioning

confidence: 99%

Nasal Biopsies of Children Exposed to Air Pollutants

et al. 2001

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“…The need for more works on this subject is justified by the fact that the ozone gas is able, according to Victorin (1992), to oxidize organic cellular components, such as amino acids and polyunsaturated fatty acids. Therefore, it is necessary to establish concentrations of the gas, and appropriate exposure periods of time, so that the quality of peanut is preserved, regarding the physical and chemical aspects.…”

Section: Introductionmentioning

confidence: 99%

Effect of the ozonization process on the quality of peanuts and crude oil

Alencar

Faroni²,

Soares³

et al. 2011

Rev. bras. eng. agríc. ambient.

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The purpose of this study was to evaluate the effect of ozone on the quality of peanut grains and crude oil extracted from these grains. Peanut samples of 1 kg were used, with a moisture content of 8.0% w.b. and stored in 3 L glass recipients. The ozonization process utilized ozone gas concentrations of 13 and 21 mg L . Evaluation of peanut quality consisted of analysis for moisture content, electrical conductivity, lipid concentration and peanut color. The qualitative parameters of the crude oil evaluated were free fatty acids, peroxide index and iodine index. In general there was no alteration in peanut quality due to ozone, except for the coloration of the peanuts. With regard to parameters related to the crude oil extracted from the peanut, there were no qualitative alterations due to ozone exposure. It was concluded that, despite depigmentation of the skin surrounding the peanuts, the quality of the peanuts and the extracted crude oil is not affected by exposure to ozone gas at concentrations up to 21 mg L . Para avaliação da qualidade dos grãos foram analisados os parâmetros teor de água, condutividade elétrica, teor de lipídios e coloração dos grãos. Quantificaram-se, para a avaliação da qualidade do óleo bruto, o teor de ácidos graxos livres, o índice de peróxido e o índice de iodo. Em geral, não ocorreu alteração da qualidade do amendoim em virtude a exposição ao ozônio, exceto para a variável coloração dos grãos. Com relação aos parâmetros relacionados ao óleo bruto, não ocorreram alterações qualitativas devido a exposição ao ozônio. Concluiu-se que, apesar de ocorrer despigmentação da película que envolve os grãos de amendoim, a qualidade dos grãos e do óleo bruto extraído não é afetada pela exposição ao gás ozônio em concentrações de até 21 mg L -1

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“…In dieser Studie wurde lediglich ein geringfügig vermindertes Geburtsgewicht bei einer Ozon-Konzentration von 2,4 mg/m 3 gefunden. (Victorin 1992). Andererseits sind die in-vivo-Ergebnisse aber nicht so eindeutig negativ, daß eine Genotoxizität von Ozon in vivo ausgeschlossen werden kann.…”

Section: Allergene Wirkungunclassified

“…Es liegen mehrere Studien zur Frage einer kanzerogenen Wirkung von Ozon vor (Lippmann 1992;Victorin 1992;Witschi 1988Witschi , 1991. Die älteren Studien, in denen Ozonkonzentrationen von über 2,0 mg/m 3 eingesetzt wurden, sind nach Ansicht der Experten nicht lege artis durchgeführt worden.…”

Section: Langzeitstudienunclassified

Ozon [MAK Value Documentation in German language, 1995]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 21. Lieferung, Ausgabe 1995 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik Erfahrungen beim Menschen Einmalige inhalative Exposition Wiederholte inhalative Exposition Tierexperimentelle Befunde und in‐vitro‐Untersuchungen Akute und subakute inhalative Toxizität Subchronische und chronische Toxizität Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Wirkung auf das Immunsystem Bewertung

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Review of the genotoxicity of ozone

Cited by 128 publications

References 66 publications

Nasal Biopsies of Children Exposed to Air Pollutants

Nasal Biopsies of Children Exposed to Air Pollutants

Effect of the ozonization process on the quality of peanuts and crude oil

Ozon [MAK Value Documentation in German language, 1995]

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