Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders

Agazzi, A.; Ponti, Fabrizio De; Giorgio, Roberto De; Candura, Stefano M.; Anselmi, Laura; Cervio, Elisabetta; Nucci, A. Di; Tonini, Marcello

doi:10.1016/s1590-8658(03)00277-9

Cited by 33 publications

(18 citation statements)

References 40 publications

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“…These results suggest that SSRI administration might cause a form of “serotonergic vulnerability” [119] whereby serotonergic neurotransmission becomes more sensitive to environmental or genetic factors that would inhibit 5-HT synthesis, such as an unbalanced diet [120], [121]. In fact, tryptophan depletion has pronounced depressive effects on patients taking SSRIs [27], [37]–[44].…”

Section: Discussionmentioning

confidence: 98%

Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain

et al. 2009

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BackgroundSerotonin (5-HT) is a neurotransmitter with important roles in the regulation of neurobehavioral processes, particularly those regulating affect in humans. Drugs that potentiate serotonergic neurotransmission by selectively inhibiting the reuptake of serotonin (SSRIs) are widely used for the treatment of psychiatric disorders. Although the regulation of serotonin synthesis may be an factor in SSRI efficacy, the effect of chronic SSRI administration on 5-HT synthesis is not well understood. Here, we describe effects of chronic administration of the SSRI citalopram (CIT) on 5-HT synthesis and content in the mouse forebrain.Methodology/Principal FindingsCitalopram was administered continuously to adult male C57BL/6J mice via osmotic minipump for 2 days, 14 days or 28 days. Plasma citalopram levels were found to be within the clinical range. 5-HT synthesis was assessed using the decarboxylase inhibition method. Citalopram administration caused a suppression of 5-HT synthesis at all time points. CIT treatment also caused a reduction in forebrain 5-HIAA content. Following chronic CIT treatment, forebrain 5-HT stores were more sensitive to the depleting effects of acute decarboxylase inhibition.Conclusions/SignificanceTaken together, these results demonstrate that chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain. Furthermore, our results indicate that chronic 5-HT reuptake inhibition renders 5-HT brain stores more sensitive to alterations in serotonin synthesis. These results suggest that the regulation of 5-HT synthesis warrants consideration in efforts to develop novel antidepressant strategies.

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Section: Discussionmentioning

confidence: 98%

Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain

et al. 2009

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“…Serotonin has been suggested to play a role also in the GI system, by mediating motor activity, secretion processes, and visceral sensitivity. Serotonin is also involved in the pathophysiology of some gastrointestinal disorders such as irritable bowel syndrome [13,14]. Upon ingestion, TRP is first converted to 5-hydroxytryptophan (5-HTP) along the serotonin pathway by the rate-limiting enzyme tryptophan hydroxylase.…”

Section: Introductionmentioning

confidence: 99%

Evolution of tryptophan and its foremost metabolites’ concentrations in milk and fermented dairy products

2016

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“…We know that, l-Tryptophans (Trp) level in plasma is indicative of the extent of hepatic disease [49]; l-cysteine is a widely used antioxidant in food industry and also crucial in many biological processes, and l-Tyrosine (Tyr) is the direct precursor of various hormones and biogenic amines [50]. Our group has fabricated an electrochemical sensor ( Fig.…”

Section: Electrochemical Biosensors: Technologymentioning

confidence: 99%

Electrochemical Biosensors for Medical and Food Applications

2008

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Sensing and quantification of DNA and proteins are becoming increasingly important in biochemistry, medicine and biotechnology. Traditional analytical techniques are lagging behind the demand for more information in less time, at a lower cost. An important step forward in this pursuit is to identify an analyte using its electrochemical behavior and to convert its presence and concentration into perceivable and distinct electrical signals. This review covers the strategies for electrochemical sensing of biomolecules, mainly, DNA and proteins by label-based and label-free approaches using disposable electrochemical printed chips and carbon nanotube based field effect transistors. Issues, such as ease of preparation, robustness, sensitivity, and realization of mass production of the detection strategies are also considered. A good coverage of the published literature, mostly, a wide treatment of original research articles reporting novel principles has been made. Finally, this review may help the researchers in developing an understanding of miniaturized electrochemical biosensors and their possible applications in medical and food science, with directions for future research.

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Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders

Cited by 33 publications

References 40 publications

Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain

Chronic Citalopram Administration Causes a Sustained Suppression of Serotonin Synthesis in the Mouse Forebrain

Evolution of tryptophan and its foremost metabolites’ concentrations in milk and fermented dairy products

Electrochemical Biosensors for Medical and Food Applications

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