Review of the Literature for Mandibular Metastasis Illustrated by a Case of Lung Metastasis to the Temporomandibular Joint in an HIV-Positive Patient

Katsnelson, Alexander; Tartakovsky, Julia V.; Miloro, Michael

doi:10.1016/j.joms.2009.07.075

Cited by 17 publications

(12 citation statements)

References 48 publications

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“…Consistent with this, we consider that the main neoplasm that involves the mandible are the carcinomas originated in breast, lung and prostate, which disseminates via hematogenous [9]. The first theory considers that the amount of substantial hematopoietic marrow in the condyle is scarce compared with the one in the mandibular body, which limit the dissemination probabilities [9]. In second place the condyle irrigation is "separated" or "isolated", depending principally from the maxillary and superficial temporal artery, different arteries than those irrigating the medular body.…”

Section: Discussionsupporting

confidence: 53%

“…In the beginning, these symptoms are attributed to TMJ disorders, keeping the patient in interocclusal splint therapy for approximately 4 months. Radiographic appearance is usually an osteolysis [9], despite that there is no pathognomonic image for mandibular metastasis, radiolucency is a common finding [13]. In our report, slight degenerative changes in the condylar cortex were found, which progresses to complete osteolysis of condyle and mandibular ramus in a period of only 6 months.…”

Section: Discussionmentioning

confidence: 47%

“…To understand them is important to know that the main route for metastasis are via lymphatic and via hematogenous [8]. Consistent with this, we consider that the main neoplasm that involves the mandible are the carcinomas originated in breast, lung and prostate, which disseminates via hematogenous [9]. The first theory considers that the amount of substantial hematopoietic marrow in the condyle is scarce compared with the one in the mandibular body, which limit the dissemination probabilities [9].…”

Section: Discussionmentioning

confidence: 88%

See 2 more Smart Citations

Lung Adenocarcinoma Metastasis in Mandibular Condyle - Case Report and Literature Review

Barreda¹,

Daniel²,

Emilio³

et al. 2018

Int Arch Oral Maxillofac Surg

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The neoplasm that metastasize more frequently in the oral cavity are those that originate in breast, lung, prostate, gastrointestinal system and kidney [4]. In a literature review performed by the authors of this article, 38 cases of mandibular condyle metastasis were identified. Seven cases correspond to metastasis whose primary tumor was located in the lungs. The first warning signs of possible malignant processes are pain, paresthesia, swelling, tooth mobility and pathological fractures. About 59% of the cases that reported metastasis in the condylar region are presented mimicking symptoms of temporomandibular disorders [2]. In the case of the tumors described in the condylar region, the most frequent symptoms are: disfunction, pain, trismus, limitation and deviation of the mandibular opening, swelling, osteolytic radiographic lesion and pathologic fractures of the condyle neck that may suggest metastatic malignant processes [2]. Due to the non-specific of the clinical signs, the possibility to confuse the diagnose with benign pathologies and the high mortality when is found distant metastasis. The objective of this study is to present a case of a mandibular condyle metastasis that present itself as the only initial manifestation mimicking signs and symptoms of temporomandibular disorders.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 88%

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Lung Adenocarcinoma Metastasis in Mandibular Condyle - Case Report and Literature Review

Barreda¹,

Daniel²,

Emilio³

et al. 2018

Int Arch Oral Maxillofac Surg

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“…Moreover breast cancer and prostate cancer often occur in older people in whom the bone marrow of the jaw is even more reduced [54]. It is probable that the mandible is more affected by bone metastatic growth than the maxilla because of the pattern of its blood supply, and because the mandibular retromolar area, the jaw site most affected by metastases, has more red bone marrow than other jaw sites [60]. …”

Section: Metastases To the Jawsmentioning

confidence: 99%

A short account of metastatic bone disease

2011

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In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical distribution of the blood vessels, by the genetic profile of the cancer cells and by the biological characteristics of the bone microenvironment that favour the growth of metastatic cells of certain cancers.Metastases to bone may have either an osteolytic or an ostoblastic phenotype. The interaction in the bone microenvironment between biological factors secreted by metastatic cells, and by osteoblasts and osteoclasts, and the osteolytic and osteoblastic factors released from the organic matrix mediate a vicious cycle characterized by metastatic growth and by ongoing progressive bone destruction. This interaction determines the phenotype of the metastatic bone disease.

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“…Other symptoms included mass formation, discomfort, and dysphagia (Table 2). Many clinical manifestations are similar to those of TMD including pain [44], joint sound during mandibular movement [22], tenderness to palpation [49], occlusal change [40], and abnormal mandibular movements, including deviation at the opening, limited opening, and lateral movement [53]. However, many patients presented with atypical symptoms different from typical TMD, such as preauricular tender swelling (59.7%) [50], and facial paresthesia (14.5%) [60].…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations and diagnostic approach to metastatic cancer of the condyle

Jung

2017

Oral Biol Res

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·············································································································································································Metastatic malignancy on the mandibular condyle is a very rare, but life-threatening condition that is frequently misdiagnosed as temporomandibular joint disorder (TMD) and other dental diseases. The researchers report on a patient who was referred with an initial diagnosis of TMD, due to symptoms resembling TMD, such as limited mouth opening with pain on the temporomandibular joint (TMJ) and mandibular deviation during mouth opening. However, the final diagnosis was malignant condylar metastasis. The researchers reviewed available literature on malignant condylar metastatic cases focusing on initially misdiagnosed cases to find additional diagnostic information. The analysis revealed that some aspects of malignant condylar metastasis were overlooked, which frequently led to misdiagnosis and incorrect treatment. Further understanding of condylar metastasis might lead to early detection of occult primary cancer, possibly preventing further metastasis.

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Review of the Literature for Mandibular Metastasis Illustrated by a Case of Lung Metastasis to the Temporomandibular Joint in an HIV-Positive Patient

Cited by 17 publications

References 48 publications

Lung Adenocarcinoma Metastasis in Mandibular Condyle - Case Report and Literature Review

Lung Adenocarcinoma Metastasis in Mandibular Condyle - Case Report and Literature Review

A short account of metastatic bone disease

Clinical manifestations and diagnostic approach to metastatic cancer of the condyle

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