Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.

Kausar, Juveriyah; Muthumani, Durai; Hedina, Agaath; Sivasamy,; Anand, Arumugam Vijaya

doi:10.5530/pj.2016.4.2

Cited by 20 publications

(16 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its leaves are known to treat dysentery, cough, asthma, worms and vomiting. The white latex is used as eye drops to cure conjunctivitis, it is applied on swellings, piles and boils [27]. Its main components are flavonoids, terpenoids and phenols [28].…”

Section: Euphorbia Hirta (Leaves)mentioning

confidence: 99%

Phytochemical analysis and in vitro screening of antifungal activity of Jatropha multifida, Euphorbia hirta, Occimum gratissimum and Mitracarpus scaber leaves extract

N¹,

A²,

E³

et al. 2021

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

The research study was to understudy the qualitative and quantitative phytochemical compounds and antifungal activity of methanolic extracts of Jatropha multifida, Euphorbia hirta, Occimum gratissimum and Mitracarpus scaber leaves against 12 species of fungi. The 8 phytochemical compounds tested were saponin, phenol, tannin, flavonoids, steroids, terpenoid, alkaloid and glycoside. The antifungi sensitivity test was analysed by Kirby-bauer disc diffusion method. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) was analysed by broth tube dilution method followed by subculturing the relative samples. The plant extracts were prepared in the concentration range of 6.25, 12.5, 25, 50,100 and 200 mg/ml. The antifungal sensitivity test showed that Jatropha multifida (200mg/ml) was weakly effective against Fusarium solani and resistant against others. Occimum gratissimum, Euphorbia hirta and Mitracarpus scaber at (200mg/ml) respectively was highly effective on most of the fungi species tested with zone of inhibition of 10-20mm. Jatropha multifida had MIC and MFC (>200mg/ml), Occimum gratissimum had MIC and MFC (100 and >100mg/ml), Euphorbia hirta (25-200 and 50 - >200mg/ml) and Mitracarpus scaber had (25 - 100 and 50-200mg/ml) on most test isolates respectively. Investigations showed, Mitracarpus scaber were highly effective, followed by Euphorbia hirta, Occimum gratissimum and Jatropha multifida on the test organisms and could be attributed to the presence of phytochemical compounds and as such can be harnessed and used as a source of alternative medicine especially in the tropics like the South-eastern Nigeria.

show abstract

Section: Euphorbia Hirta (Leaves)mentioning

confidence: 99%

Phytochemical analysis and in vitro screening of antifungal activity of Jatropha multifida, Euphorbia hirta, Occimum gratissimum and Mitracarpus scaber leaves extract

N¹,

A²,

E³

et al. 2021

GSC Biol. and Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…A list of active phytochemical constituents of E. hirta has been reported in recent investigation including alkaloids, flavanoids, phenol, tannins, saponnins, steroids, terpenoids, quinone, catechin, coumarins, sugars, proteins, and anthraquinone. [17,[23][24][25][26] Moreover, the presence of numerous chief chemical constituents in E. hirta including quercetrin, polyphenolic flavonoid, and palmitic acid confirmed its antioxidant, anti-inflammatory, hepatoprotective, antiobesity, and antidiabetic potential of this folk medicine. [17][18][19][20][21] The antihyperglycemic activity can block the associated complications, and thus, the herbal extract of E. hirta may produce the pivotal action against DM and associated cardiorenal diseases.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Katare¹

2018

IJGP

View full text Add to dashboard Cite

Introduction: Euphorbia hirta is a traditional medicine having unique combination of possible therapeutic action including antidiabetic, antioxidant, and antiobesity. The present study focuses to evaluate the therapeutic potency of ethanolic extract of E. hirta against diabetes mellitus (DM) and associated cardiorenal injury. Materials and Methods: DM was induced by administration of double cycle of repetitive (single injection for 3 alternative days in one cycle) dose of streptozotocin (20 mg/kg/i.p) in high-fat diet animals. Fasting and postprandial blood glucose level, glycated hemoglobin A1c (HbA1c), C-peptide, and plasma insulin were measured to confirm the induction of DM. Serum lipid profile and thiobarbituric acid reactive substances (TBARS) were measured in diabetic animals. Diabetic animals were further evaluated for cardiorenal toxicity after 12 weeks by measuring creatine kinase MB, lactate dehydrogenase, cardiac troponin I, serum creatinine, and blood urea nitrogen, respectively. Structural alteration was observed by histological assessments of pancreatic β-cells and cardiorenal tissues. Results: A significant increased level of fasting and postprandial blood glucose, and HbA1c and decreased level of C-peptide and plasma insulin were observed in diabetic animals. Furthermore, diabetic animals showed abnormal lipid profile (dyslipidemia) and increase serum TBARS (oxidative stress). In addition, the increased level of cardiorenal biomarkers in diabetic animals confirmed the associated abnormalities. The treatment of E. hirta (400 mg/kg/p.o) significantly overcomes the perturbed level of hyperglycemic, lipid profile, oxidative stress, and cardiorenal biomarkers. Histological evaluation of pancreatic and cardiorenal tissue also validates the significant protection of E. hirta against DM and-induced cardiorenal toxicity. Discussion and Conclusion: Thus, E. hirtainduced cardiorenal protection may associate with its antihyperglycemic, antidyslipidemia, and antioxidant potential.

show abstract

“…However, the metabolite profile of the leaves of this plant has largely remained under-explored [17,18]. Euphorbia hirta (EH) is another plant, the extract of which is known for the treatment of gastrointestinal diseases, and disorders [19]. It is also used as an antidote and pain reliever for scorpion stings or snakebites [20].…”

Section: Introductionmentioning

confidence: 99%

Antityrosinase Activity of Combretum micranthum, Euphorbia hirta and Anacardium occidentale Plants: Ultrasound Assisted Extraction Optimization and Profiling of Associated Predominant Metabolites

et al. 2020

View full text Add to dashboard Cite

Tyrosinase is an important component of the enzyme polyphenol oxidase, which upon contact with the phenolic substrates forms the pigment melanin and induces undesirable food browning. The phenolic and triterpenoid compounds that naturally occur in plants are well known as tyrosinase inhibitors. Combretum micranthum (CM) leaves, Euphorbia hirta (EH) plant, and Anacardium occidentale (AO) fruits are traditionally known to have potential anti-tyrosinase activities. The aim of this study was to optimize the ultrasound-assisted extraction of secondary metabolites from these matrices, and to evaluate in tubo the antityrosinase activity of these extracts. Efforts were also taken to profile the secondary metabolites, mainly the phenolic and triterpenoid compounds, in order to understand their probable association with tyrosinase inhibition. The optimal ultrasound-assisted extraction conditions for simultaneous extraction of phenolic, and triterpenoid compounds were determined. The aqueous fraction of these extracts showed significant antityrosinase activity, with the CM leaves exhibiting the strongest inhibitory effect (IC50 of 0.58 g·L−1). The predominant metabolic compounds from these natural extracts were putatively identified by using a high-resolution quadrupole-time of flight (QToF) LC-MS instrument. The high-resolution accurate mass-based screening resulted in identification of 88 predominant metabolites, which included dihydrodaidzein-7-O-glucuronide, micromeric acid, syringic acid, morin, quercetin-3-O-(6″-malonyl-glucoside), 4-hydroxycoumarin, dihydrocaffeic acid-3-O-glucuronide, to name some, with less than 5 ppm of mass error.

show abstract

Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.

Cited by 20 publications

References 16 publications

Phytochemical analysis and in vitro screening of antifungal activity of Jatropha multifida, Euphorbia hirta, Occimum gratissimum and Mitracarpus scaber leaves extract

Phytochemical analysis and in vitro screening of antifungal activity of Jatropha multifida, Euphorbia hirta, Occimum gratissimum and Mitracarpus scaber leaves extract

Untitled

Antityrosinase Activity of Combretum micranthum, Euphorbia hirta and Anacardium occidentale Plants: Ultrasound Assisted Extraction Optimization and Profiling of Associated Predominant Metabolites

Contact Info

Product

Resources

About