Review of the role of leptin in the regulation of male reproductive function

Zhang, J.; Gong, Min

doi:10.1111/and.12965

Cited by 33 publications

(20 citation statements)

References 88 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between fat mass and puberty may be mediated by several factors, including leptin, the levels of which are very low in our patients. Many animal experiments and human studies have shown that leptin is an important signal in the initiation of puberty (31). Thus, mice or humans who have mutation in leptin gene exhibit central hypogonadism, which is reversed by leptin treatment.…”

Section: Discussionmentioning

confidence: 99%

Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency

Moniez

Pienkowski

Lepage

et al. 2018

European Journal of Endocrinology

View full text Add to dashboard Cite

Context: Abnormalities in the hypothalamo-pituitary-gonadal axis have long been reported in Noonan syndrome (NS) males with only few data available in prepubertal children.Objective: The aim of this study was to describe the gonadal function of NS males from childhood to adulthood. Design: It is a retrospective chart review. Patients and methods: A total of 37 males with a genetically confirmed diagnosis of NS were included. Clinical and genetic features, as well as serum hormone levels (LH, FSH, testosterone, anti-Müllerian hormone (AMH), and inhibin B) were analysed. Results: Of the 37 patients, 16 (43%) children had entered puberty at a median age of 13.5 years (range: 11.4-15.0 years); age at pubertal onset was negatively correlated with BMI SDS (r = −0.541; P = 0.022). In pubertal boys, testosterone levels were normal suggesting a normal Leydig cell function. In contrast, NS patients had significant lower levels of AMH (mean SDS: −0.6 ± 1.1; P = 0.003) and inhibin B (mean SDS: −1.1 ± 1.2; P < 0.001) compared with the general population, suggesting a Sertoli cell dysfunction. Lower AMH and inhibin B levels were found in NS-PTPN11 patients, whereas these markers did not differ from healthy children in SOS1 patients. No difference was found between cryptorchid and non-cryptorchid patients for AMH and inhibin B levels (P = 0.43 and 0.62 respectively). Four NS-PTPN11 patients had a severe primary hypogonadism with azoospermia/cryptozoospermia. Conclusions: NS males display Sertoli cell-specific primary testicular insufficiency, whereas Leydig cell function seems to be unaffected.

show abstract

Section: Discussionmentioning

confidence: 99%

Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency

Moniez

Pienkowski

Lepage

et al. 2018

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…A possible positive regulatory effect of resistin on steroidogenic activity in the testicular Leydig cell has been suggested (Roumaud & Martin, 2015). Even though the exact role of leptin on the male reproductive function has not been revealed, it is proposed that leptin would involve in suppression of testicular steroidogenesis (Zhang & Gong, 2018). These findings reflex the existence of a complex regulatory mechanism on the male reproduction by adipocytokines.…”

Section: Discussionmentioning

confidence: 99%

Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal Fat at Different Postnatal Ages

Lee

2020

Dev. Reprod.

View full text Add to dashboard Cite

The fat pad defined as the epididymal fat is located at the head part of the epididymis. However, another fat mass is present near the caudal epididymis, named tail epididymal fat. The present research was focused to determine the expression of adipocyte-associated molecules in the mouse tail epididymal fat at different postnatal ages, including 2, 5, 8, and 12 months of age. The quantitative real-time PCR analysis showed continuous increases of expression levels of delta like non-canonical Notch ligand 1, leptin, and resistin as postnatally aged. The transcript level of peroxisome proliferator-activated receptor gamma was the highest at 5 months of age, remaining at a steady level until 12 months of age. Expression levels of fatty acid binding protein 4, leptin, and adiponectin were significantly increased until 8 months of age, persisting the level at 12 months of age. The transcript level of fatty acid synthase was significantly increased at 8 months of age, without a further change of the level at 12 months of age. These findings exhibited the expression of adipocyte-associated genes which were also detected at the ordinary epididymal fat pad. However, expression patterns of these genes in the tail epididymal fat are different with those in the distal and proximal epididymal fat, suggesting distinct characteristics and/or functions of the tail epididymal fat.

show abstract

“…To date, we know that leptin plays a crucial role in controlling reproductive function, acting on all levels of the hypothalamusepituitaryegonadal axis, and also may have local effects on the function of testis. 30,31 Leptin and its functional receptor have been detected in prepubertal and adult testes, even though with several differences in cellular localization among species, suggesting the potential for leptin to directly modulate testicular functions. In particular, it has been reported that testicular steroidogenesis as well as germ and Sertoli cell function may be modulated by leptin, either as autocrine/paracrine or endocrine signals.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in the past few years several compounds have been described as potential tools to affect leptin-induced cancer growth and progression. 14,27e29 Although leptin and its receptors have been detected in testicular cells, suggesting their direct involvement in testicular functions, 30,31 their expression in human testicular seminoma as well as the role of this adipokine in the development and promotion of testicular seminoma remains largely unknown.…”

mentioning

confidence: 99%

Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth

Panza

Gelsomino

Malivindi

et al. 2019

The American Journal of Pathology

View full text Add to dashboard Cite

Review of the role of leptin in the regulation of male reproductive function

Cited by 33 publications

References 88 publications

Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency

Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency

Expression of Adipocyte-Associated Genes in the Mouse Tail Epididymal Fat at Different Postnatal Ages

Leptin Receptor as a Potential Target to Inhibit Human Testicular Seminoma Growth

Contact Info

Product

Resources

About