Review of the Treatment of Mycosis Fungoides and SéZary Syndrome : A Stage-Based Approach

Expression of special AT-rich sequence-binding protein 1 is an independent prognostic factor in cutaneous T-cell lymphoma

“…A 10-point intensity scoring scale was used considering maximum expression as 10 and minimum expression as 0. Patients with none or low SATB1 expression (0-2) were considered SATB1-negative, whereas patients with moderate (3)(4) and high SATB1 expression (5)(6)(7)(8)(9)(10) were considered SATB1-positive. To minimize variations in staining intensity among different experiments, several steps were taken: i) a positive (thymus, LyP) and negative (SS) control were routinely included to check staining procedure; ii) as smooth muscle cells of vessels, fibroblast and epithelial cells are weakly reactive, these cells were applied as internal controls; iii) the same batch of antibody was used for all slides.…”

“…Immunomodulatory treatment is used to reduce side-effects, i.e. interferon α, bexarotene, deacetylase inhibitors, denileukin diftitox and methotrexate (4)(5)(6). The SS, another frequently occurring and the most aggressive CTCL, is characterized by erythroderma, lymphadenopathy and neoplastic T cells (Sézary cells) in the peripheral blood.…”

Case report Mycosis fungoides - a case report

“…It is not uncommon for the diagnosis of MF to remain elusive for a long time, requiring observation and repeated biopsies with clinicopathological correlation. We could suspect this disease when the patient presents a long (years) history of unmanageable, recurrent, pruritic skin eruption with poikilodermatous or polymorphic skin involvement [10]. On the other hand, it could overlap clinicopathologic findings with various reactive dermatoses as well as conflicting clinical pres-entations and pathologic features [3].…”

“…These therapies include: skin-directed therapies, such as ultraviolet light, topicals, and radiation; a large group of systemic agents ranging from retinoids through other biologics to chemotherapy; and an increasing role for allogeneic stem cell transplantation [10]. However, the treatment individualization, based on appropriate matching of the therapeutic strategies with clinical stage, and with the patient's complaints, plays the most important role in a successful outcome.…”

Are there still other asbestos-related malignancies to be discovered?

“…The results of a multicentered European casecontrol study between 1995 and 1997, on seven rare cancers, including mycosis fungoides, showed that some occupational factors were associated to the onset of mycosis fungoides. Workers in glass, paper and pulp industries, pottery, and ceramic factories carried the highest risk to develop mycosis fungoides [10]. The most associations were made with the following occupational exposures: aromatic hydrocarbons, hydrazine, halogenated hydrocarbons, formaldehyde and mustard gas [11,12].…”