Review of thrombotic thrombocytopenic purpurain the setting of systemic lupus erythematosus

Musio, Franco; Bohen, Erin M.; Yuan, Christinana M.; Welch, Paul G.

doi:10.1016/s0049-0172(98)80023-1

Cited by 144 publications

(89 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In adults, SLE develops before the onset of TTP in most cases (73%); in 15% of patients, especially in children, SLE and TTP occur concomitantly, and in 12% TTP precedes the diagnosis of SLE (8). In our patients, SLE was present 1-12 years before the onset of TTP in all cases, the degree of 984 Dold et al thrombocytopenia was moderate, and none of the patients exhibited a platelet count Ͻ50,000/l.…”

Section: Discussionmentioning

confidence: 44%

Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: Distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome

Dold¹,

Singh²,

Sarwar³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 44%

Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: Distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome

Dold¹,

Singh²,

Sarwar³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

“…In a review of 28 patients with SLE and TMHA performed by Nesher et al, 53 tests for LA or aCL were reported in eight patients and were positive in five. The contribution of aPL to the association of TTP and SLE was also suggested by the review of Musio et al 44 These authors detected aCL in nearly half of the patients tested (8/17) and the LA was seen in 14% (2/14).…”

Section: Discussionmentioning

confidence: 69%

Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies

Espinosa

Bucciarelli²,

Cervera³

et al. 2004

Annals of the Rheumatic Diseases

143

View full text Add to dashboard Cite

Objective: To analyse the clinical and laboratory features of patients with thrombotic microangiopathic haemolytic anaemia (TMHA) associated with antiphospholipid antibodies (aPL). Methods: A computer assisted (PubMed) search of the literature was performed to identify all cases of TMHA associated with aPL from 1983 to December 2002. Results: 46 patients (36 female) with a mean (SD) age at presentation of TMHA of 34 (15) years were reviewed. Twenty eight (61%) patients had primary antiphospholipid syndrome (APS). TMHA was the first clinical manifestation of APS in 26 (57%) patients. The clinical presentations were haemolytic-uraemic syndrome (26%), catastrophic APS (23%), acute renal failure (15%), malignant hypertension (13%), thrombotic thrombocytopenic purpura (13%), and HELLP (haemolysis, elevated liver enzymes, and low platelet count in association with eclampsia) syndrome (4%). Lupus anticoagulant was detected in 86% of the episodes of TMHA, and positive anticardiolipin antibodies titres in 89%. Steroids were the most common treatment (69% of episodes), followed by plasma exchange (PE) (62%), anticoagulant or antithrombotic agents (48%), immunosuppressive agents (29%), and immunoglobulins (12%). Recovery occurred in only 10/29 (34%) episodes treated with steroids, and in 19/27 (70%) episodes treated with PE. Death occurred in 10/46 (22%) patients. Conclusions:The results emphasise the need for systematic screening for aPL in all patients with clinical and laboratory features of TMHA. The existence of TMHA in association with an APS forces one to rule out the presence of the catastrophic variant of this syndrome. PE is indicated as a first line of treatment for all patients with TMHA associated with aPL.

show abstract

“…The coexistence of SLE and TTP, although rare, has been reported to be more common in children with SLE than in adults [4.]The diagnostic criteria for TTP have changed significantly from the original pentad of thrombocytopenia, microangiopathic hemolytic anemia, neurological abnormalities, renal abnormalities, and fever, [5] to the dyad of thrombocytopenia and microangiopathic hemolytic anemia [6]. The coexistence of 5 symptoms, typical of TTP and often described in textbooks, is not frequent in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients

Palaniappan

Lionel

Agarwal

et al. 2014

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE) very rarely present simultaneously and pose a diagnostic and therapeutic dilemma to the physician. Prompt diagnosis and management with plasma exchange and immunosuppression is life-saving. To describe the effectiveness of cryosupernatant and steroids in pediatric SLE with TTP. We describe three children aged 12-14 years with SLE who were diagnosed with TTP based on fever, CNS manifestations, ANA, anti-dsDNA, anti-sm positivity, hypocomplementemia, and microangiopathic anemia with thrombocytopenia.

show abstract

Review of thrombotic thrombocytopenic purpurain the setting of systemic lupus erythematosus

Cited by 144 publications

References 55 publications

Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: Distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome

Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: Distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome

Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies

Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients

Contact Info

Product

Resources

About