Review of Topical Treatment of Upper Tract Urothelial Carcinoma

Nepple, Kenneth G.; Joudi, Fadi N.; O’Donnell, Michael A.

doi:10.1155/2009/472831

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Before restaging, 11 of 38 (28.9%) positive upper tract cases had undergone treatment for upper tract disease, as described previously 9 . Similar results were seen for cases of isolated positive upper tract cytology and negative bladder biopsies with four of 17 (23.5%) patients undergoing upper tract treatment before restaging.…”

Section: Resultssupporting

confidence: 82%

Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high‐grade non‐muscle invasive bladder cancer

et al. 2012

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Abbreviations & AcronymsObjectives: To investigate whether random bladder, and prostatic urethral biopsies and individual upper tract cytologies (restaging) provide useful clinical information in addition to cystoscopy and bladder cytology in assessing initial intravesical therapy response for high-grade non-muscle invasive bladder cancer. Methods: We retrospectively reviewed records of all patients who underwent restaging at our institution after treatment for high-grade non-muscle invasive bladder cancer (Ta, T1 and Tis) between January 2000 and October 2009. A total of 78 patients undergoing 116 consecutive restagings were included. The presence of intravesical cancer at restaging was assessed by cystoscopy, bladder wash cytology and random bladder biopsies, whereas ureteral and prostatic urethral disease was determined using upper tract barbotage cytology and prostatic urethral biopsies. Results: Indication for intravesical treatment was carcinoma in situ in 86, high-grade T1 in 16 and high-grade Ta in 14 cases. A total of 48 patients had primary disease and 68 had recurrence. Overall, 59 of 116 (50.9%) restagings showed positive bladder or prostatic biopsy and/or a positive cytology localized to the upper tract. Of the total number of recurrences, 12.9% (15 of 116) showed a negative cystoscopy and negative bladder cytology, and would have been missed on routine surveillance. A total of 23 of 116 (19.8%) restagings showed evidence of prostatic urethral and or ureteral disease. Conclusion: Roughly 25% of high-grade non-muscle invasive bladder cancer early recurrences after induction intravesical therapy would go unnoticed without the addition of random and directed prostate biopsies, and isolated upper tract cytologies to standard cystoscopy and bladder cytology.

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Section: Resultssupporting

confidence: 82%

Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high‐grade non‐muscle invasive bladder cancer

et al. 2012

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“…However, the role of instillation therapy for upper urinary tract tumors has been equivocal, and its long-term effectiveness has not been elucidated. 7 To the best of our knowledge, this is the first reported case of creation of an irrigation technique for the treatment of renal pelvic tumors in a solitary kidney after ipsilateral ureterectomy. The advantages of this technique are: (i) the application of constant low pressure to minimize the risk of bacterial sepsis or systemic absorption of the agent; (ii) contact of all urothelium with instillation media; (iii) ability to repeat instillation therapy at low cost; and (iv) safety of collecting the instillation media in the bag.…”

Section: Discussionmentioning

confidence: 83%

“…The role of intravesical immunotherapy using bacillus Calmette–Guérin or chemotherapy using mitomycin C for non‐muscle‐invasive urothelial carcinoma of the bladder has been established. However, the role of instillation therapy for upper urinary tract tumors has been equivocal, and its long‐term effectiveness has not been elucidated …”

Section: Discussionmentioning

confidence: 99%

Novel constant‐pressure irrigation technique for the treatment of renal pelvic tumors after ipsilateral ureterectomy

et al. 2014

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Abbreviations & AcronymsAbstract: We herein report a case of a renal pelvic tumor that developed in the residual left renal pelvis after right nephroureterectomy, left ureterectomy and total cystectomy in a patient with multiple urothelial tumors. The tumor was endoscopically ablated through a nephrostomy tract, and mitomycin C irrigation was carried out. We designed a novel constant-pressure irrigation system for effective and safe irrigation into the closed space of the renal pelvis. We created a hole in the urine bag tube, inserted a 5-Fr open-end ureteral catheter through the hole and kept the tip of the catheter at the end of the nephrostomy tube. The urine bag tube was placed 20 cm above the kidney level, and mitomycin C was continuously irrigated into the renal pelvis for 1 h. Six-weekly treatments were carried out, and tumor recurrence was not identified for 1 year.

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Percutaneous Instillation of Chemolytic, Chemotherapeutic, and Antifungal Agents

Elkoushy

Violette

Andonian

2018

Smith's Textbook of Endourology

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Review of Topical Treatment of Upper Tract Urothelial Carcinoma

Cited by 7 publications

References 21 publications

Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high‐grade non‐muscle invasive bladder cancer

Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high‐grade non‐muscle invasive bladder cancer

Novel constant‐pressure irrigation technique for the treatment of renal pelvic tumors after ipsilateral ureterectomy

Percutaneous Instillation of Chemolytic, Chemotherapeutic, and Antifungal Agents

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