Review of Tretinoin-Benzoyl Peroxide in The Treatment of Acne Vulgaris

Singh, Rohan; Chatim, A; Kankaria, Aman; Feldman, Steven R.

doi:10.36849/jdd.6808

Cited by 1 publication

(1 citation statement)

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“…Among the myriad of nanotechnology-based methodologies examined for acne treatment, the utilization of nano-sized drug delivery systems stands as one of the most extensively researched [88]. These delivery systems can encapsulate acne medications, such as retinoids [89] and benzoyl peroxide [90], in nano-sized particles to improve their solubility, bioavailability, and stability [91]. The deployment of nanoparticles can potentially enhance the infiltration of these therapeutic agents into the skin strata, the very site of acne manifestation [92].…”

Section: Nanotechnology and Acne Treatmentmentioning

confidence: 99%

Recent advances in nanofiber-based systems for acne treatment: A comprehensive review

Tören¹,

Buzgo²

2023

Preprint

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Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety and efficacy of these treatments. Future research may focus on developing multifunctional nanofibers that combine active ingredients with other properties, such as antimicrobial, anti-inflammatory, and wound-healing properties, to provide a comprehensive approach to acne treatment. Moreover, the development of nanofiber-based skincare products may have a significant impact on the cosmetic industry. Overall, while there are still challenges to overcome, the potential benefits of encapsulated nanofibers for acne treatment make them an exciting and promising area of research for the future. In particular, the integration of smart drug delivery systems and responsive materials may enable the development of more personalized and effective treatments for acne. The development of new materials and encapsulation techniques, as well as the exploration of combination therapies that target multiple aspects of acne pathogenesis, are also future perspectives for encapsulated nanofibers in acne treatment.

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