2017
DOI: 10.1111/jvp.12450
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Review of triazine antiprotozoal drugs used in veterinary medicine

Abstract: Triazines are relatively new antiprotozoal drugs that have successfully controlled coccidiosis and equine protozoal myeloencephalitis. These drugs have favorably treated other protozoal diseases such as neosporosis and toxoplasmosis. In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalitis, neos… Show more

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Cited by 65 publications
(38 citation statements)
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“…Since 1980s, triazine derivatives have been used globally in the veterinary community to combat the detrimental effects of protozoan parasites (Stock et al, 2018). Toltrazuril and diclazuril are the known members of this class and were used primarily for the treatment of coccidian parasites including Eimeria spp .…”
Section: Introductionmentioning
confidence: 99%
“…Since 1980s, triazine derivatives have been used globally in the veterinary community to combat the detrimental effects of protozoan parasites (Stock et al, 2018). Toltrazuril and diclazuril are the known members of this class and were used primarily for the treatment of coccidian parasites including Eimeria spp .…”
Section: Introductionmentioning
confidence: 99%
“…However, the widely use of triazine coccidiostats for their clinical effects have generated resistance to the genus Eimeria in recent years [5,6]. Fortunately, no crossresistance was observed in triazine coccidiostats [5].…”
Section: Introductionmentioning
confidence: 99%
“…Ethanamizuril (Figure 1), a novel triazine coccidiostat, namely (N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy) phenyl)acetamide, has been independently established by the Shanghai Veterinary Research Institute of the Chinese Academy of Agricultural Sciences in recent years and exert wide application prospective in future [5,7]. In China and Japan Patents, the chemical synthesis of ethanamizuril and the chemical structure have been published [8].…”
Section: Introductionmentioning
confidence: 99%
“…Consequently, the resulting letdown of treatment promotes a constant demand for innovative products with safe and e cient. Triazines are benzene-aceto-nitrile compounds including diclazuril, toltrazuril, ponazuril and clazuril, which have been used globally in the interception and therapy of protozoal diseases, most commonly in coccidiosis of veterinary interest since 1980s [5]. However, the widely use of triazine coccidiostats for their clinical effects have generated resistance to the genus Eimeria in recent years [5,6].…”
Section: Introductionmentioning
confidence: 99%
“…However, the widely use of triazine coccidiostats for their clinical effects have generated resistance to the genus Eimeria in recent years [5,6]. Fortunately, no cross-resistance was observed in triazine coccidiostats [5].…”
Section: Introductionmentioning
confidence: 99%