This paper presents state-of-the-art review on the fundamental and frontier research of flow boiling heat transfer, mechanisms and prediction methods including models and correlations for heat transfer in microscale channels. First, fundamental issues of current research on flow boiling in microscale channels are addressed. These mainly include the criteria for macroscale and microscale channels. Then, studies on flow boiling heat transfer behaviours and mechanisms in microscale channels are presented. Next, the available correlations and models of flow boiling