Review of zirconia-based bioceramic: Surface modification and cellular response

Soon, Ginny; Pingguan‐Murphy, Belinda; Lai, Khin Wee; Akbar, Sheikh A.

doi:10.1016/j.ceramint.2016.05.077

Cited by 156 publications

(67 citation statements)

References 142 publications

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“…As previously demonstrated, the cellular response in terms of adhesion, proliferation and mineralization on ZrO 2 depends on its chemical composition and on the physicochemical surface properties (topography, wettability), as well as porous microstructure characteristics. In this work, the in vitro assays demonstrated that the FA coating of ZrO 2 scaffold yielded a favorable combination of surface and microstructure properties to support MC3T3‐E1 and BMSC spreading and survival over a short‐term culture period.…”

Section: Discussionmentioning

confidence: 75%

Processing, structural, and biological evaluations of zirconia scaffolds coated by fluorapatite

León

Albano

Garrido

et al. 2018

Int J Applied Ceramic Tech

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Highly porous zirconia (ZrO2) scaffolds fabricated by the replication method were coated with fluorapatite (FA). The FA coating was obtained by dipping the ZrO2 scaffolds into stabilized aqueous FA slips having different viscosity values (≤5.0 mPa.s). The influence of the FA slip viscosity and the immersion time on the reduction in the scaffold porosity and microstructure of the coated scaffolds were investigated. Cell spreading and survival of bone marrow‐derived stromal cells (BMSC) and pre‐osteoblastic MC3T3‐E1 cells on the uncoated and coated scaffolds were examined using fluorescence and SEM microscopy, and MTT assay.The FA slip with the lowest viscosity value did not lead to a continuous film along the strut network and the macropores remained uncoated. The slips with the highest viscosity value produced a partial blocking of macropores. The porous structure obtained after coating with slips of 2.2 mPa.s viscosity for 2 seconds exhibited a low reduction in porosity and pore size (400‐420 μm), due to the formation of the FA layer, and a continuous film distributed along the strut surfaces. Morphology, spreading, and survival of BMSC and MC3T3‐E1 cells over a 7‐day culture period evidenced good biocompatibility of FA‐coated ZrO2 scaffolds processed by dip coating.

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Section: Discussionmentioning

confidence: 75%

Processing, structural, and biological evaluations of zirconia scaffolds coated by fluorapatite

León

Albano

Garrido

et al. 2018

Int J Applied Ceramic Tech

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“…With the biostability of most widely‐used titanium becoming increasingly questioned, including the release of metal ions, zirconia as an implant material alternative has gained interest over recent years . Although long‐term clinical data are scarce in supporting the clinical success of zirconia as a dental implant material, it combines high biocompatibility and good mechanical properties, allowing surviving high stress‐bearing situations in posterior areas, with excellent optical advantages, which is well appreciated due to the known cases of metallic discoloration of titanium …”

Section: Introductionmentioning

confidence: 99%

“…Extensive investigations have examined the biologic behavior of zirconia, including in vivo studies that have shown comparable osteointegration and biocompatibility to titanium, and in some studies, higher bone affinity in bone osteointegration during initial bone healing was observed . For instance, an in vivo study claimed that zirconia was able to achieve the same degree of bone‐to‐implant contact and bone volume density compared to titanium with significantly higher surface roughness (Ra) in 4 weeks …”

Section: Introductionmentioning

confidence: 99%

Adhesive and oxidative response of stem cell and pre‐osteoblasts on titanium and zirconia surfaces in vitro

Wei

Gong

Pow

et al. 2019

J of Invest & Clin Dent

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Aim:The aim of the present study was to investigate the initial stem cell and preosteoblast cell adhesion and oxidative response on zirconia in comparison with titanium.Methods: Human dental pulp stem cells (DPSC) and murine pre-osteoblasts (MC3T3-E1) cells were cultured on zirconia and titanium surfaces, and at 3-, 12-, and 24-hour intervals, cell viability and morphology were determined with tetrazolium based colorimetric assay, scanning electron microscopy, and immunofluorescence analysis. The in situ reactive oxygen species level of both cells on each material surface was examined after 24-hour culture. Results: Both DPSC and MC3T3-E1 cells revealed comparable morphological features during 24-hour cell adhesion processes, with cells continued expanding of cell size and increasing of cell viability on titanium and zirconia surfaces during 24-hour culture. Zirconia demonstrated relatively higher mean cell viability compared to titanium within 24-hour culture, with significantly higher DPSC viability at 12 hours after seeding (P < 0.05). Relatively higher mean reactive oxygen species levels in both DPSC and MC3T3E1 were found on zirconia surfaces after 24-hour culture compared to titanium. Conclusions:From the results, zirconia as a potential dental implant substrate demonstrated equivalent or better initial cellular responses compared to titanium. K E Y W O R D Scell adhesion, dental implant, reactive oxygen species, titanium, zirconia

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“…This type of treatment has been studied by several authors . using phosphoric acid solution (H 3 PO 4 ) in order to increase the specific contact area and surface energy of the substrate, that is, to increase the adhesion on the surface of the bioinert scaffolds, facilitating apatite growth and then became then as a bioactive scaffold …”

Section: Introductionmentioning

confidence: 99%

“…2,22 using phosphoric acid solution (H 3 PO 4 ) in order to increase the specific contact area and surface energy of the substrate, that is, to increase the adhesion on the surface of the bioinert scaffolds, facilitating apatite growth and then became then as a bioactive scaffold. 23 Herein we produced and characterize a bioactive scaffold based on alumina matrix scaffolds containing 5% by volume of zirconia inclusions, produced by the replica method. Then, the obtained porous scaffold surfaces were chemically treated with H 3 PO 4 and coating biomimetically with calcium phosphates to produce a bioactive scaffold to bone tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

et al. 2018

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The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al O containing 5% by volume of ZrO were produced by the replica method. These scaffolds had their surfaces chemically treated with phosphoric acid and were coated with calcium phosphate using the biomimetic method simulated body fluid (SBF, 5×) for 14 days. The scaffolds, before and after biomimetic coating, were characterized mechanically, morphologically and structurally by axial compression tests, scanning electron microscopy, microtomography, apparent porosity, X-ray diffractometry, near-infrared spectroscopy, inductively coupled plasma optical emission spectroscopy, energy dispersive X-ray spectroscopy and reactivity. The in vitro cell viability and formation of mineralization nodules were used to identify the potential for bone regeneration. The produced scaffols after immersion in SBF were able to induce the nodules formation. These characteristics are advantaged by the formation of different phases of calcium phosphates on the material surface in a reduced incubation period. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2615-2624, 2018.

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Review of zirconia-based bioceramic: Surface modification and cellular response

Cited by 156 publications

References 142 publications

Processing, structural, and biological evaluations of zirconia scaffolds coated by fluorapatite

Processing, structural, and biological evaluations of zirconia scaffolds coated by fluorapatite

Adhesive and oxidative response of stem cell and pre‐osteoblasts on titanium and zirconia surfaces in vitro

Surface modification using the biomimetic method in alumina‐zirconia porous ceramics obtained by the replica method

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