Review on Anti-cancer and Anti-microbial Applications of Curdlan Biomaterials

Ganie, Showkat Ali; Rather, Luqman Jameel; Li, Qing

doi:10.1007/s10924-021-02299-9

Cited by 13 publications

(4 citation statements)

References 76 publications

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“…The intrachain hydrogen bond between the O(2) hydroxyls on glucopyranose residues results in single helices, while the triple helices originate from the hydrogen bond between O(4) and O(6). 152 Furthermore, Curdlan has antitumor, anti-infective, anti-inflammatory, immunomodulating, and anti-HIV properties. The triple helical structure of Curdlan is crucial for anticancer and antitumor activity.…”

Section: Cellulosementioning

confidence: 99%

“…The low-set and high-set gels are primarily cross-linked by triple helices and single helices. The intrachain hydrogen bond between the O(2) hydroxyls on glucopyranose residues results in single helices, while the triple helices originate from the hydrogen bond between O(4) and O(6) . Furthermore, Curdlan has antitumor, anti-infective, anti-inflammatory, immunomodulating, and anti-HIV properties.…”

Section: Properties Of Polysaccharides Used In Dn Hydrogelmentioning

confidence: 99%

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Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications

Wang,

Liao,

Zhang

2023

Biomacromolecules

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Polysaccharides are carbohydrate polymers that are major components of plants, animals, and microorganisms, with unique properties. Biological hydrogels are polymeric networks that imbibe and retain large amounts of water and are the major components of living organisms. The mechanical properties of hydrogels are critical for their functionality and applications. Since synthetic polymeric double-network (DN) hydrogels possess unique network structures with high and tunable mechanical properties, many natural functional polysaccharides have attracted increased attention due to their rich and convenient sources, unique chemical structure and chain conformation, inherently desirable cytocompatibility, biodegradability and environmental friendliness, diverse bioactivities, and rheological properties, which rationally make them prominent constituents in designing various strong and tough polysaccharide-based DN hydrogels over the past ten years. This review focuses on the latest developments of polysaccharide-based DN hydrogels to comprehend the relationship among the polysaccharide properties, inner strengthening mechanisms, and applications. The aim of this review is to provide an insightful mechanical interpretation of the design strategy of novel polysaccharide-based DN hydrogels and their applications by introducing the correlation between performance and composition. The mechanical behavior of DN hydrogels and the roles of varieties of marine, microbial, plant, and animal polysaccharides are emphatically explained.

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Section: Cellulosementioning

confidence: 99%

Section: Properties Of Polysaccharides Used In Dn Hydrogelmentioning

confidence: 99%

Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications

Wang,

Liao,

Zhang

2023

Biomacromolecules

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“…In recent years, natural polysaccharides have been used more and more frequently as drug carriers, , owing to their desirable properties such as biological compatibility, biodegradability, nontoxicity, renewability, low cost, and processability. − Pectin and chitosan can swell and specifically degrade under the action of polysaccharide enzymes secreted by colonic flora. , Earlier studies verified that the gelation property of pectin/chitosan complexes could be improved by adjusting external conditions and acted for potential targeted drug delivery. − …”

Section: Introductionmentioning

confidence: 99%

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Zhang

et al. 2023

Biomacromolecules

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The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn’s disease is extremely cloudy. Maintaining the level of remission lesions in colitis is the default treatment attitude at present. Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment. Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release. Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine. In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres. In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.

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“…The use of lower temperatures (55–60 °C) during the heating of the aqueous curdlan suspension results in obtaining a gel with an unstable, reversible structure, while the use of high temperatures (>80 °C) ensures the formation of a stable, compact gel [ 15 , 16 ]. Moreover, curdlan has a number of biological activities valuable in regenerative medicine, such as antibacterial, anticancer, immunomodulatory, and antiviral properties [ 17 , 18 ]. In these studies, based on the experience gained in the production of curdlan-containing biomaterials for bone tissue regeneration, a gelation temperature of 96 °C was used for the production of granules [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Composition of Mesoporous Polymer–Ceramic Nanocomposite Granules for Bone Regeneration

et al. 2023

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Difficult-to-treat bone damage resulting from metabolic bone diseases, mechanical injuries, or tumor resection requires support in the form of biomaterials. The aim of this research was to optimize the concentration of individual components of polymer–ceramic nanocomposite granules (nanofilled polymer composites) for application in orthopedics and maxillofacial surgery to fill small bone defects and stimulate the regeneration process. Two types of granules were made using nanohydroxyapatite (nanoHA) and chitosan-based matrix (agarose/chitosan or curdlan/chitosan), which served as binder for ceramic nanopowder. Different concentrations of the components (nanoHA and curdlan), foaming agent (sodium bicarbonate—NaHCO3), and chitosan solvent (acetic acid—CH3COOH) were tested during the production process. Agarose and chitosan concentrations were fixed to be 5% w/v and 2% w/v, respectively, based on our previous research. Subsequently, the produced granules were subjected to cytotoxicity testing (indirect and direct contact methods), microhardness testing (Young’s modulus evaluation), and microstructure analysis (porosity, specific surface area, and surface roughness) in order to identify the biomaterial with the most favorable properties. The results demonstrated only slight differences among the resultant granules with respect to their microstructural, mechanical, and biological properties. All variants of the biomaterials were non-toxic to a mouse preosteoblast cell line (MC3T3-E1), supported cell growth on their surface, had high porosity (46–51%), and showed relatively high specific surface area (25–33 m2/g) and Young’s modulus values (2–10 GPa). Apart from biomaterials containing 8% w/v curdlan, all samples were predominantly characterized by mesoporosity. Nevertheless, materials with the greatest biomedical potential were obtained using 5% w/v agarose, 2% w/v chitosan, and 50% or 70% w/v nanoHA when the chitosan solvent/foaming agent ratio was equal to 2:2. In the case of the granules containing curdlan/chitosan matrix, the most optimal composition was as follows: 2% w/v chitosan, 4% w/v curdlan, and 30% w/v nanoHA. The obtained test results indicate that both manufactured types of granules are promising implantable biomaterials for filling small bone defects that can be used in maxillofacial surgery.

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Review on Anti-cancer and Anti-microbial Applications of Curdlan Biomaterials

Cited by 13 publications

References 76 publications

Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications

Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Optimization of the Composition of Mesoporous Polymer–Ceramic Nanocomposite Granules for Bone Regeneration

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