Review on Antihyperlipedemia Lipophilic Drugs and Their Novel Formulation Approaches

Khairnar, Ashwini; Shelke, Santosh; Rathod, Vivek D.; Kalawane, Yogesh; Jagtap, Ashish

doi:10.22159/ijpps.2017v9i9.19301

Cited by 5 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 28 d of oral treatment of nanosponges at doses ranging between 300 to 2000 mg/kg, negative mortality was seen in male Wistar rats. In addition, there were no variations in appearance [91]. The animals treated showed no signs of diarrhea, tremors, convulsions, or other symptoms as compared to the control groups.…”

Section: Toxicity Studies and Acute Toxicological Studymentioning

confidence: 81%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

View full text Add to dashboard Cite

Recent advancements in nanotechnology have resulted in improved medicine delivery to the target site. Nanosponges are three-dimensional drug delivery systems that are nanoscale in size and created by cross-linking polymers. The introduction of Nanosponges has been a significant step toward overcoming issues such as drug toxicity, low bioavailability, and predictable medication release. Using a new way of nanotechnology, nanosponges, which are porous with small sponges (below one µm) flowing throughout the body, have demonstrated excellent results in delivering drugs. As a result, they reach the target place, attach to the skin's surface, and slowly release the medicine. Nanosponges can be used to encapsulate a wide range of medicines, including both hydrophilic and lipophilic pharmaceuticals. The medication delivery method using nanosponges is one of the most promising fields in pharmacy. It can be used as a biocatalyst carrier for vaccines, antibodies, enzymes, and proteins to be released. The existing study enlightens on the preparation method, evaluation, and prospective application in a medication delivery system and also focuses on patents filed in the field of nanosponges.

show abstract

Section: Toxicity Studies and Acute Toxicological Studymentioning

confidence: 81%

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Sharma¹,

Sharma

Gupta³

2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…Moreover, the lipids in nanoemulsion preparations are suitable carriers for increasing the bioavailability of drugs at their target points [34]. SNEDDS have been shown to significantly boost drug release by 89% compared to 24% for traditional formulation [35].…”

Section: Discussionmentioning

confidence: 99%

The Development and Validation of Analytical Method for Evaluating Gallic Acid in Ethyl Acetate Fraction (Eaf) of Snedds Formulation: Quantitative Analysis With in Vitro Assay

APRIDAMAYANTI,

PRATIWI,

SARI

2024

Int J App Pharm

View full text Add to dashboard Cite

Objective: This study aimed to develop a simple, accurate, precise, sensitive, robust, and stable analytical method for the evaluation of gallic acid in Self-Nanoemulsifying Drug Delivery System (SNEDDS) incorporating ethyl acetate fraction (EAF) of Melastoma malabathricum leaves in combination with Gentamicin. Methods: Validation process followed ICH guidelines and applied a reverse phase HPLC method with a mobile phase of acetonitrile-phosphoric buffer at pH 3.03 (20:80 v/v). The stationary phase consisted of a VP-ODS shim-pack C-18 column (250x4.6 mm) with a flow rate of 0.2 ml/min and detection at 263 nm using an Ultraviolet detector. Additionally, antioxidant activity was assessed through the DPPH and FRAP methods, and SPF value was determined with a UV/Vis spectrophotometer in the 290-390 nm wavelength range. Results: The results showed that the retention time of quercetin was 16.648 min with a tailing factor of 1.623. The regression equation (y=224689x-989000) had a concentration range of 10-55 µg/ml and a correlation value of 0.9920. Limit of Detection (LOD) and Limit of Quantification (LOQ) were found to be 2.394±0.086 and 7.254±0.260 µg/ml, respectively. Method accuracy, determined by recovery values at concentrations of 50%, 100%, and 150%, ranged from 91.18% to 109.49%. Repeatability inter-day variations were expressed as %RSD values of 1.027-1.963% for AUC and 0.150-0.145 for RT. Moreover, the applied method showed stability within a temperature range of 14 °C–35 °C. Analysis showed gallic acid content of 1.773±0.049 mg/g in SNEDDS EAF formulation. Antioxidant activity measured through the DPPH and FRAP methods yielded IC50 values of 4.167±0.552 µg/ml and 20.253±0.619 µg/ml, respectively, while SPF value at SNEDDS concentration of 150 µg/ml was 36.993±0.183. Conclusion: This study successfully developed a precise, accurate, specific, and stable method for quantifying gallic acid levels in SNEDDS EAF of Melastoma malabathricum leaves in combination with Gentamicin. Therefore, SNEDDS EAF formulation exhibited an effective wound-healing potential, supported by a robust quality control process.

show abstract

“…Dyslipidemias are generally characterized clinically by increased plasma levels of cholesterol and triglycerides or both, variably accompanied by reduced levels of high-density lipoprotein (HDL) cholesterol [1]. It has been proved that elevated plasma levels of cholesterol are responsible for atherosclerosis in man, and epidemiological data suggest that elevated plasma levels of HDL have a protective effect [5]. The majority of patients with dyslipidemia have some combination of genetic predisposition and environmental contribution [1].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Study to Evaluate the Efficacy of Vamana Karma in the Management of Dyslipidemia

Singh

Srivastava

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective:The aim of the present study is to evaluate the efficacy of Vamana karma in the management of dyslipidemia.Methods: Patients were selected from the OPD and IPD at the Department of Panchakarma, Hospital of Rishikul Campus, Uttarakhand Ayurved University, Haridwar. Patients in Group A will be administered with two sittings of Vamana procedure. In Group B, 20 patients will be treated with atorvastatin for 60 days in dose of 10 mg once daily after meals with water. Results:The overall assessment of the therapy was decided on the basis of improvement in biochemical parameter (serum lipid profile) by applying statistics. Vamana karma had statistically highly significant result in all the objective parameters except high-density lipoprotein [HDL]. Conclusion:Thus, it can be concluded that dyslipidemia is a form of Kaphavikara specifically may be Medodushti in the form of Abaddha meda. Vamana karma is highly effective in correcting serum lipid profile except HDL and very low-density lipoprotein but have better effect than the standard drug in both of them. Vamana karma can be used for the effective and safe management of dyslipidemia.

show abstract

Review on Antihyperlipedemia Lipophilic Drugs and Their Novel Formulation Approaches

Cited by 5 publications

References 35 publications

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

Nanosponges: As a Dynamic Drug Delivery Approach for Targeted Delivery

The Development and Validation of Analytical Method for Evaluating Gallic Acid in Ethyl Acetate Fraction (Eaf) of Snedds Formulation: Quantitative Analysis With in Vitro Assay

A Clinical Study to Evaluate the Efficacy of Vamana Karma in the Management of Dyslipidemia

Contact Info

Product

Resources

About