Review on Biomedical Applications of Marine Algae-Derived Biomaterials

Nayak, Gayatree; Sahu, Akankshya; Bhuyan, Sanat Kumar; Bhuyan, Ruchi; Kuanar, Ananya; Kar, Dattatreya

doi:10.13189/ujph.2022.100102

Cited by 12 publications

(6 citation statements)

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“…In a recent study conducted in 2023, IC50 value for DPPH 120.74±2.83 μg/mL and less antioxidant activity was found in the North Central Plateau of Keonjhar district with an IC50 value of 514.06±5.64 μg/mL for DPPH assay. The value in our study (0.005±0.000 mg/mL) was found to be higher compared to this study [57] …”

Section: Resultscontrasting

confidence: 89%

In Vitro Determination of Nitric Oxide Synthase Inhibition, Antioxidant Capacity and Phenolic Content of Various Natural Products (Bee and Herbal Products)

Yaylaci Karahalil,

Bakirhan,

Kara

2024

Chemistry & Biodiversity

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It is obvious that the oxidation process is an undeniable fact and when it comes to aging, one of the first solutions that come to mind is natural products. When it comes to natural products, both plants and bee products play an important, almost combative role against oxidation. For this purpose, natural products of both plant and animal origin were considered together in our study: Linden, green tea, aronia, wild grapes, myrtle, blueberries and basil, honey, pollen and propolis. Total phenolic content values of the extracts ranged between 49.28 and 3859.06 mg gallic acid equivalent/100 g, and propolis, green tea, chestnut flower and aronia samples were found to have the highest values. When looking at the NOS inhibition potential, it was determined that propolis, pollen and aronia samples had the highest percentage inhibition values of 98.11, 92.29, 83.44, respectively. Antioxidant activities of methanolic extracts were investigated using iron(III) reducing/antioxidant capacity (FRAP), 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity test and NOS inhibition tests. The phenolic composition of methanolic extracts was tested using the RP‐HPLC‐UV (high‐performance liquid chromatographic method with ultraviolet) method with 19 phenolic standards.

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Section: Resultscontrasting

confidence: 89%

In Vitro Determination of Nitric Oxide Synthase Inhibition, Antioxidant Capacity and Phenolic Content of Various Natural Products (Bee and Herbal Products)

Yaylaci Karahalil,

Bakirhan,

Kara

2024

Chemistry & Biodiversity

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“…Their environmental applications are diverse and include heavy metal sequestering, water treatment, coloring agents, food additives, and preparation of hydrocolloids [6]. Miscellaneous secondary metabolites were isolated from algae, which exhibited propitious bioactivities including antimicrobial, anti-inflammatory, cytotoxic, antioxidant, anticoagulant, and antifungal effects [7][8][9]. Several algal-driven constituents were patented and marketed for nutritional and medicinal uses [10].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking

et al. 2023

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Brown algae comprise up to 2000 species with wide dissemination in temperate zones. A comprehensive untargeted metabolic profiling guided by molecular networking of three uninvestigated Red-Sea-derived brown algae, namely Sirophysalis trinodis, Polycladia myrica, and Turbinaria triquetra, led to the identification of over 115 metabolites categorized as glycerolipids, fatty acids, sterol lipids, sphingolipids, and phospholipids. The three algae exhibited low-to-moderate antioxidant capacity using DPPH and ABTS assays. Preliminary in vitro antiproliferative studies showed that the algal extracts displayed high cytotoxic activity against a panel of cancer cell lines. The most potent activity was recorded against MCF-7 with IC50 values of 51.37 ± 1.19, 63.44 ± 1.13, and 59.70 ± 1.22 µg/mL for S. trinodis, P. myrica, and T. triquetra, respectively. The cytotoxicity of the algae was selective to MCF-7 without showing notable effects on the proliferation of normal human WISH cells. Morphological studies revealed that the algae caused cell shrinkage, increased cellular debris, triggered detachment, cell rounding, and cytoplasmic condensation in MCF-7 cancer cells. Mechanistic investigations using flow cytometry, qPCR, and Western blot showed that the algae induced apoptosis, initiated cell cycle arrest in the sub-G0/G1 phase, and inhibited the proliferation of cancer cells via increasing mRNA and protein expression of p53, while reducing the expression of PI3K, Akt, and mTOR.

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“…5 Marine algae have been extensively focused on due to their anti-coagulant properties, and anti-coagulant properties are achieved due to the presence of sulphated glycosaminoglycans. 6 Numerous polysaccharides derived from marine algae are alginate, fucoidan, ascophyllan, and porphyrin. 7 Alginate is an anionic polysaccharide, and it is composed of linear copolymer constituents like (1–4)-linked β- d mannuronic acid (M) and α- l -guluronic acid (G).…”

Section: Natural Polymersmentioning

confidence: 99%

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review

Bhattacharjee,

Savargaonkar,

Tahir

et al. 2024

RSC Adv.

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Review on Biomedical Applications of Marine Algae-Derived Biomaterials

Cited by 12 publications

References 0 publications

In Vitro Determination of Nitric Oxide Synthase Inhibition, Antioxidant Capacity and Phenolic Content of Various Natural Products (Bee and Herbal Products)

In Vitro Determination of Nitric Oxide Synthase Inhibition, Antioxidant Capacity and Phenolic Content of Various Natural Products (Bee and Herbal Products)

Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking

Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review

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