Review on computational modeling for the property, process, product and performance (PPPP) characteristics of additively manufactured porous magnesium implants

Imran, Ramsha; Rashid, Ans Al; Koç, Muammer

doi:10.1016/j.bprint.2022.e00236

Cited by 30 publications

(12 citation statements)

References 109 publications

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“…[42][43][44] An interesting possibility is offered by bone tissue printing for the fabrication of fractured parts that should be removed or low in bone density through 3D Bioprinting. 45,46 Another improvement concerns the use of an optimized infill for printing bone that is more accurate than the one used and more like a trabecular structure so that it is visually increasingly accurate and close to reality. For the future, it also desired to achieve the possibility of making a print that has not only three different zones but that the variation in density is continuous following the bone matrix and not differentiated by n zones.…”

Section: Discussionmentioning

confidence: 99%

3D-printing of porous structures for reproduction of a femoral bone

et al. 2023

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Background: 3D-printing has shown potential in several medical advances because of its ability to create patient-specific surgical models and instruments. In fact, this technology makes it possible to acquire and study physical models that accurately reproduce patient-specific anatomy. The challenge is to apply 3D-printing to reproduce the porous structure of a bone tissue, consisting of compact bone, spongy bone and bone marrow. Methods: An interesting approach is presented here for reproducing the structure of a bone tissue of a femur by 3D-printing porous structure. Through the process of CT segmentation, the distribution of bone density was analysed. In 3D-printing, the bone density was compared with the density of infill. Results: The zone of compact bone, the zone of spongy bone and the zone of bone marrow can be recognized in the 3D printed model by a porous density additive manufacturing method. Conclusions: The application of 3D-printing to reproduce a porous structure, such as that of a bone, makes it possible to obtain physical anatomical models that likely represent the internal structure of a bone tissue. This process is low cost and easily reproduced.

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Section: Discussionmentioning

confidence: 99%

3D-printing of porous structures for reproduction of a femoral bone

et al. 2023

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“…AM technology has been widely explored by biomedical engineers to manufacture a variety of customized products for healthcare systems. The technology is highly beneficial to develop patient-specific anatomic models and medical implants by using an appropriate 3D printing process [193] , [194] , [195] . The transformation of reasonable AM and biopolymer availability are significant elements for their selection in biomedical applications [196] , [197] , [198] .…”

Section: Additive Manufacturing Techniquesmentioning

confidence: 99%

Additive manufacturing of sustainable biomaterials for biomedical applications

Arif

Khalid

Noroozi

et al. 2023

Asian Journal of Pharmaceutical Sciences

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“…Recently, magnesium and its alloys have been focused on as promising candidates for metallic degradable porous scaffold applications. − In general, metallic biomaterials possess high Young’s modulus compared to natural bone and result in bone resorption owing to stress shielding. , However, Mg is a lightweight material (1.74 g/cm 3 ) with mechanical properties (Young’s Modulus 45 GPa) very similar to natural bone. , Thus, it eliminates the complication of the stress shielding phenomenon. Furthermore, Mg is the fourth most abundant cation available in the human body, and its degradation product can easily be excreted with urine without causing any harmful effects .…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Engineered Magnesium Scaffolds for Bone Tissue Engineering

Dutta

Roy

2023

ACS Biomater. Sci. Eng.

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Significant attention has been drawn in recent years to develop porous scaffolds for tissue engineering. In general, porous scaffolds are used for non-load bearing applications. However, various metallic scaffolds have been investigated extensively for hard tissue repair due to their favorable mechanical and biological properties. Stainless steel (316L) and titanium (Ti) alloys are the most commonly used material for metallic scaffolds. Although stainless steel and Ti alloys are employed as scaffold materials, it might result in complications such as stress shielding, local irritation, interference with radiography, etc. related to the permanent implants. To address the above-mentioned complications, degradable metallic scaffolds have emerged as a next generation material. Among the all metallic degradable scaffold materials, magnesium (Mg) based material has gained significant attention owing to its advantageous mechanical properties and excellent biocompatibility in a physiological environment. Therefore, Mg based materials can be projected as load bearing degradable scaffolds, which can provide structural support toward the defected hard tissue during the healing period. Moreover, advanced manufacturing techniques such as solvent cast 3D printing, negative salt pattern molding, laser perforation, and surface modifications can make Mg based scaffolds promising for hard tissue repair. In this article, we focus on the advanced fabrication techniques which can tune the porosity of the degradable Mg based scaffold favorably and improve its biocompatibility.

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Review on computational modeling for the property, process, product and performance (PPPP) characteristics of additively manufactured porous magnesium implants

Cited by 30 publications

References 109 publications

3D-printing of porous structures for reproduction of a femoral bone

3D-printing of porous structures for reproduction of a femoral bone

Additive manufacturing of sustainable biomaterials for biomedical applications

Recent Developments in Engineered Magnesium Scaffolds for Bone Tissue Engineering

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