“…91,92 Paper is a favorable substrate to manufacture POC in-vitro diagnostic devices due to its abundant availability, affordability, chemical stability, biodegradability, prominent porous fibrous network with high surface area for interactions, and natural capillary-driven mass transport of liquid samples. [93][94][95][96][97] Various well-established technologies for the manufacture and processing of paper have been applied for the fabrication of paper-based microfluidic devices, including folding, cutting, 98,99 masking, 100,101 laser writing, 102 and printing. [103][104][105] However, paper can vary immensely based on its composition, internal structure, and wettability owing to its sources and manufacturing method, 106 for example, filter paper, 107,108 chromatography paper, 109 common printer paper, 110 and paper towels.…”